Insomnia in neurological diseases
Journal of Psychosomatic ResearchPublished 1 January 1993
Michael S. Aldrich
Citations23
SJR quartileQ1
SJR score1.31
SNIP1.10
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Nocturnal behavioral disturbances are a major contributor to institutionalization of patients with neurological diseases, and respiratory abnormalities of sleep can be life-threatening.
Abstract
Sleep disturbance, common in many neurological diseases, can be caused by underlying CNS pathology, altered motor system function, associated cognitive and psychiatric disorders, secondary effects of the disease such as pain and immobility, and medication effects. Nocturnal behavioral disturbances are a major contributor to institutionalization of such patients, and respiratory abnormalities of sleep can be life-threatening. Rational approach to diagnosis and treatment can lead to significant improvements in many such patients.
Keywords
MedicineNeuroscience
Elsevier eBooksPrinciples and Practice of Sleep Medicine
5,133 Citations2011Meir H. Kryger, Thomas Roth +1 more
JAMAThe Impact of Dementia on the Family
740 Citations1982Peter V. Rabins
Patients suffering from an irreversible dementia reported disturbances of patient behavior such as catastrophic reactions, waking at night, suspiciousness, and communication disorders, some of which can be alleviated by physician-initiated intervention.
New England Journal of MedicineFatal Familial Insomnia and Dysautonomia with Selective Degeneration of Thalamic Nuclei
636 Citations1986E Lugaresi, Rossella Medori +7 more
The thalamus is affected in diffuse degenerative processes of the nervous system and it has not been established whether a genetically determined degenerative disease may be limited in patients with this organ.
Movement DisordersSleep disorders and sleep effect in Parkinson's disease
357 Citations1990Stewart A. Factor, Terence McAlarney +2 more
JAMARapid Eye Movement Sleep Behavior Disorder
313 Citations1987Carlos H. Schenck
The RBD was unrelated to psychopathologic conditions but in five cases was closely linked with major neuropathologic disorders: dementia, olivopontocerebellar degeneration, subarachnoid hemorrhage, and the Guillain-Barre syndrome.
Annals of Internal MedicineHandbook of Sleep Disorders
269 Citations1991
Thirty-six chapters cover the physiology of the EEG in sleep, primary and secondary sleep disorders, hypersomnias and relative insomnia, circadian dysfunc, and more.
Journal of Neurology Neurosurgery & PsychiatryNocturnal paroxysmal dystonia.
211 Citations1986E Lugaresi, Fabio Cirignotta +1 more
Nocturnal paroxysmal dystonia represents a syndrome of sleep-related motor attacks which comprises two variants, respectively characterised by short and long-lasting seizures.
Journal of NeurologyNocturnal sleep in huntington's disease
167 Citations1991Michael H. Wiegand, A. A. M�ller +5 more
Nocturnal sleep was studied in inpatients with Huntington's disease and patients showed an increased density of sleep spindles, correlated in part with duration of illness, severity of clinical symptoms, and degree of atrophy of the caudate nucleus.
Journal of the American Geriatrics SocietySundown Syndrome in Institutionalized Elderly
165 Citations1987Lois K. Evans
No clear pattern of behaviors evolved but sundowners were found to increase restless and verbal behavior as evening approached, and were more likely to be demented, with greater mental impairment and organic involvement than nonsundowners.
NeurologyAbnormal respiration and sudden death during sleep in multiple system atrophy with autonomie failure
163 Citations1990Frederick Munschauer, Laurence Loh +2 more
Although mean respiratory rate, tidal volume, and inspiratory Sow rate were statistically similar in both groups, the coefficients of variability in all were significantly greater in MSA-AF patients.
Journal of Neural TransmissionDream phenomena induced by chronic levodopa therapy
136 Citations1978B Sharf, Ch. Moskovitz +2 more
The patients reported three separate types of new dreams which have been classified as vivid dreams, night terrors and nightmares which are correlated to the duration of levodopa therapy although the mechanism of their production is unclear.
Journal of Neurology Neurosurgery & PsychiatryLate onset of Huntington's disease.
130 Citations1985Richard H. Myers, Daniel S. Sax +6 more
Neuropathological evaluation of two cases reveal less severe neuronal atrophy than for mid-life onset disease, and a preponderance of maternal transmission was noted in late-onset Huntington's disease.
NeurologyReversal of sleep disturbance in Parkinson's disease by antiparkinsonian therapy
121 Citations1985J. J. M. Askenasy, M. D. Yahr
Using a combined polysomnographic and electromyographic recording technique, it is found that a reversal of the light fragmented sleep pattern and normalization of muscle activity during sleep occurred after clinical improvement with dopaminergic treatment.
Electroencephalography and Clinical NeurophysiologyDifferences in sleep in patients with parkinson's disease
116 Citations1975J Mouret
The study of signs showed that association between blinking and persistence of the activity of the chin muscles during paradoxical sleep is never encountered, and the possibility that lesions of the locus coeruleus are responsible for this decrease in paradoxicalSleep is discussed.
NeurologyDiagnostic value of video‐EEG polysomnography
109 Citations1991Michael S. Aldrich, Barbara Jahnke
VPSG is superior to standard polysomnography for the evaluation of parasomnias because of the increased capability to identify and localize EEG abnormalities and to correlate behavior with EEG and polysOMnography.
Annals of NeurologySleep abnormalities in progressive supranuclear palsy
101 Citations1989Michael S. Aldrich, Norman L. Foster +3 more
Insomnia associated with progressive supranuclear palsy appears to be worse than the insomnia of Parkinson's disease or Alzheimer's disease and may be due to degenerative changes in brain structures responsible for sleep maintenance.
NeurologySleep disturbances and severity of Huntington's disease
99 Citations1985Phiroze Hansotia, Ronald Wall +1 more
Sleep functions in patients with mild and moderately severe Huntington's disease were studied, and there was a sleep disturbance characterized by prolonged sleep-onset latency, increased interspersed wakefulness, and reduced sleep efficiency.
NeurologyThe adrenoleukomyeloneuropathy complex
92 Citations1981Brian Patrick O’Neill, L. C. Mannion +1 more
It is suggested that suspicion of this disorder be high in evaluating uncertain neurologic disorders, and that identification of one manifestation of this complex should alert the clinician to the possibility of a different expression of the same complex in other family members.
NeurologyOlivopontocerebellar degeneration, abnormal sleep, and REM sleepwithout atonia
91 Citations1986M. A. Quera Salva, C Guilleminault
Polygraphic studies during sleep performed in two patients with olivopontocerebellar degeneration revealed an abnormal control of muscle tone, demonstrated by bursts of EMG activity during sleep and progressive disappearance of muscle atonia during sleep.
Electroencephalography and Clinical NeurophysiologyThe thalamus participates in the regulation of the sleep-waking cycle. A clinico-pathological study in fatal familial thalamic degeneration
77 Citations1989Paolo Tinuper, P. Montagna +5 more
The clinical and electrophysiological data, together with the pathological correlates, emphasize the role played by the thalamus in the regulation of the sleep-waking and other circadian cycles.
British Journal of Clinical PharmacologyParkinson's disease in the elderly: response to and optimal spacing of night time dosing with levodopa.
66 Citations1987AL Leeman, CJ O'Neill +6 more
A double-blind, placebo-controlled trial in eleven patients with Parkinson's disease showed that nocturnal dosing with levodopa produced a clinically significant improvement in sleep both as assessed subjectively and by measurement of number of spontaneous moves in bed.
Electroencephalography and Clinical NeurophysiologyHuntington's chorea: An electroencephalographic and psychometric study
50 Citations1974S.K. Sishta, A. Troupe +2 more
It is suggested that the main EEG changes occur at about the time of the clinical onset of the disease and that further investigations, including predictive attempts, should include sleep EEG studies.
QJMThe Late Sequelae of Poliomyelitis
49 Citations1988Robin Howard, C M Wiles +1 more
This series shows that late sequelae following poliomyelitis are common, and in particular, those who develop chest infections or new respiratory symptoms should be treated with caution as respiratory failure may rapidly supervene.
European Archives of Psychiatry and Clinical NeuroscienceBrain morphology and sleep EEG in patients with Huntington's disease
47 Citations1991Michael H. Wiegand, Arnulf Möller +3 more
It can be hypothesized that the caudate nuclei may be involved in sleep regulation; indirect evidence from studies with positron emission tomography point in the same direction.
NeurologyEEG sleep alterations in olivopontocerebellar degeneration
24 Citations1980John F. Neil, Barry Holzer +3 more
All-night polygraphic recordings of the electroencephalogram, horizontal electrooculogram, and submental electromyogram were performed in two patients with familial olivopontocerebellar degeneration, lending further support to theories linking the pontine nuclei to the primary regulation of sleep in both experimental animals and humans.
European NeurologySpindle and EEG Sleep Alterations in Subjects Affected by Cortical Cerebellar Atrophy
8 Citations2008Federico Cicirata, A Scrofani +1 more
The electroencephalographic sleep records of two BRs showed qualitative and quantitative alterations similar to those of FCA patients, even if marked to a lesser degree, and could show small cerebellar injuries which would be insufficient to induce clinical signs.