Radioimmunoassay of vasoactive intestinal peptide
Journal of Surgical ResearchPublished 1 April 1976
Amin M. Ebeid, Philip Murray, Harold Hirsch, R.I.C. Wesdorp, Josef E. Fischer
Citations34
SJR quartileQ1
SJR score0.74
SNIP0.91
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TL;DR
The results suggest that while VIP may be involved in the causation of the WDHA Syndrome, there apparently exists a form of watery diarrhea which is not associated with a tumor, and in these patients, normal levels of VIP are detectible.
Abstract
Abstract A sensitive and specific radioimmunoassay for vasoactive intestinal peptide is described. Normal levels appear to be under 100 pg/ml with an upper range of normal of approximately 200 pg/ml. Values are elevated in liver disease, and slightly following portacaval shunt. In six patients with a syndrome of watery diarrhea, three had no tumor found at autopsy, and VIP levels were normal. Large amounts of VIP were recovered from two tumors in patients with the syndrome, but normal plasma levels were recovered from one, and only mildly elevated levels in another, who was being treated with steroids. The results suggest that while VIP may be involved in the causation of the WDHA Syndrome, there apparently exists a form of watery diarrhea which is not associated with a tumor, and in these patients, normal levels of VIP are detectible.
Keywords
MedicineNeuroscience
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