Serotonergic control of prolactin release in male rats
Life SciencesPublished 1 January 1979
Juan P. Advis, James W. Simpkins, James E. Bennett, J. Meites
Citations51
SJR quartileQ1
SJR score1.31
SNIP1.07
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Observations indicate that serotonergic neurons located in the raphe' nuclei may be involved in regulating prolactin secretion in male rats.
Abstract
To further clarify the relationship between the central serotonergic system and the control of prolactin secretion, we studied the effect of dorsal raphe' lesions, electrical stimulation of the midbrain raphe' nucleus and treatment with parachlorophenylalanine (PCPA) on prolactin secretion. Radio frequency destruction of serotonergic cell bodies in the midbrain dorsal raphe' nucleus or PCPA decreased forebrain serotonin (5HT) and 5-hydroxyindoleacetic acid (5HIAA) concentration and prolactin secretion. Electrical stimulation of the raphe' increased forebrain serotonin turnover and prolactin secretion. These observations indicate that serotonergic neurons located in the raphe' nuclei may be involved in regulating prolactin secretion in male rats.
Keywords
MedicineNeuroscience
Acta Physiologica ScandinavicaAscending Monoamine Neurons to the Telencephalon and Diencephalon
1,215 Citations1966N.‐E. Andén, Annica Dahlström +4 more
A number of ascending monoamine neuron systems from the lower brain stem are demonstrated and mapped out by studying the anterograde and retrograde changes that occur in these neurons after various types of brain lesions.
British Journal of PharmacologyRapid method for the determination of 5‐hydroxytryptamine and 5‐hydroxyindoleacetic acid in small regions of rat brain
936 Citations1970G. Curzon, A. R. Green
A rapid and sensitive method for measuring 5‐hydroxytryptamine and 5-hydroxyindoleacetic acid, using o‐phthalaldehyde and L‐cysteine, is presented, enabling both compounds to be measured in small areas of rat brain.
Journal of NeurochemistryCATECHOLAMINES IN FETAL AND NEWBORN RAT BRAIN
782 Citations1973Joseph T. Coyle, D P Henry
An investigation of the effects of reserpine, pheniprazine, α‐methyl‐para‐tyrosine, diethyldithiocarbamate and l ‐DOPA on the levels of dopamine and norepinephrine in the brains of the 18‐day gestational fetus indicated that the levelsof these neurotransmitters are under controls similar to those known to occur in the brain of the adult rat.
Biochemical PharmacologyComparative effects of p-chlorophenylalanine, p-chloroamphetamine and p-chloro-N-methylamphetamine on rat brain norepinephrine, serotonin and 5-hydroxyindole-3-acetic acid
356 Citations1970Francis P. Miller, Raymond H. Cox +2 more
The time-course of effects of a single dose of p -chlorophenylanine on rat brain amines shows a significant lowering of serotonin (5HT) and 5-hydroxyindole-3-acetic acid (5HIAA) beginning on day 1 and lasting for about 8 days.
EndocrinologyEffects of Melatonin and Serotonin on the Release of FSH and Prolactin
316 Citations1971IBRAHIM A. KAMBERI, Renon S. Mical +1 more
Melatonin as well as serotonin, when injected into the third ventricle of the brain of male rats, appeared to stimulate the release of prolactin and inhibit the releaseof FSH as judged by the changes in the concentrations of these hormones in the plasma of the recipient animals.
Brain ResearchTryptophan hydroxylase activity and synaptosomal uptake of serotonin in discrete brain regions after midbrain raphe lesions: Correlations with serotonin levels and histochemical fluorescence
235 Citations1972Michael J. Kuhar, George K. Aghajanian +1 more
The results indicate that the enzyme tryptophan hydroxylase and the uptake mechanism for 5-HT are predominantly, if not uniquely, associated with terminals of the raphe system.
Brain ResearchDaily variations of serotonin metabolism in the rat brain
235 Citations1972F. Héry, Évelyne Rouer +1 more
New information concerning the circadian rhythms in 5-HT synthesis and utilization is provided and new aspects of the processes of the regulation of 5- HT metabolism in central serotoninergic neurones are discovered.
Vitamins and hormonesHypothalamic Control of Prolactin Secretion
195 Citations1972J. Meites, James A. Clemens
This chapter emphasizes the current concepts and observations hypothalamic control of prolactin secretion, and suggests a useful approach for controlling the secretion and functions of Prolactin in the organism.
Journal of Pharmacy and Pharmacologydl-5-Hydroxytryptophan-induced changes in central monoamine neurons after peripheral decarboxylase inhibition
154 Citations1971Kjell Fuxé, Larry L. Butcher +1 more
The ability of the 5‐ HT neurons to take up and accumulate 5‐HT in the presence of5‐HTP is relatively low in spite of large amounts of 5-HTP present in the brain neuropil after extracerebral decarboxylase inhibition.
Brain ResearchSelective reduction of tryptophan hydroxylase activity in rat forebrain after midbrain raphe lesions
152 Citations1971Michael J. Kuhar, Robert H. Roth +1 more
Results indicate that projections of the midbrain raphe neurons, which are believed to account for the major portion of forebraibn serotonin, also contain the bulk of the enzyme tryptophan hydroxylase in the forebrain.
Electroencephalography and Clinical NeurophysiologyNeuroscience. A laboratory manual
143 Citations1972L.T. Rutledge
EndocrinologyNeuropharmacological Regulation of Episodic Growth Hormone and Prolactin Secretion in the Rat
114 Citations1978Joseph B. Martin, D. Durand +4 more
The results indicate that several neurotransmitters, i.e., norepinephrine, serotonin, acetylcholine, and gamma-aminobutyric acid, found in high concentration in the hypothalamus, influence GH and PRL secretion.
Journal of Neural TransmissionRapid accumulation of H3-serotonin in brains of rats receiving intraperitoneal H3-tryptophan: Effects of 5, 6-dihydroxytryptamine or female sex hormones
47 Citations1973M. T. Hyypp�, Daniel P. Cardinali +2 more
The treatment of oophorectomized rats with estradiol and progesterone does not appear to modify brain serotonin synthesis, and pretreatment of rats with intraventricular 5, 6-dihydroxytryptamine reduces brain tryptophan and serotonin concentrations.