Human Growth Hormone Release: Relation to Slow-Wave Sleep and Sleep-Waking Cycles
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TL;DR
Release of human growth hormone during sleep is significantly related to slow, synchronized stages of sleep and therefore would seem to be controlled by related neural mechanisms, but when sleep-waking cycles are reversed by 12 hours, the release of growth hormone with sleep is reversed.
Abstract
Release of human growth hormone during sleep is significantly related to slow, synchronized stages of sleep and therefore would seem to be controlled by related neural mechanisms. When sleep-waking cycles are reversed by 12 hours, the release of growth hormone with sleep is reversed; thus release does not follow an inherent circadian rhythm independent of sleep.