Central effect of atrial natriuretic polypeptide on angiotensin II-stimulated vasopressin secretion in concious rats
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TL;DR
Pretreatment of alpha-human atrial natriuretic polypeptide significantly inhibited the angiotensin II (100 ng)-stimulated vasopressin secretion, suggesting that atrial c.c.v. plays regulatory roles in vasoppressin secretion in the central nervous system.
Abstract
The effect of intracerebroventricular (i.c.v.) treatment of alpha-human atrial natriuretic polypeptide on the vasopressin secretion induced by i.c.v. injection of angiotensin II was studied in conscious, unrestrained rats. Pretreatment of alpha-human atrial natriuretic polypeptide (5 micrograms) significantly inhibited the angiotensin II (100 ng)-stimulated vasopressin secretion. This result suggests that atrial natriuretic polypeptide plays regulatory roles in vasopressin secretion in the central nervous system.