Diet in pregnancy and the offspring's blood pressure 40 years later
BJOG An International Journal of Obstetrics & GynaecologyPublished 1 March 1996
Doris M. Campbell, M. H. Hall, David J.P. Barker, J. F. Cross, Alistair W. Shiell, Keith M. Godfrey
Citations347
SJR quartileQ1
SJR score1.79
SNIP1.92
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TL;DR
To determine how diet of the mother in pregnancy influences the blood pressure of the offspring in adult life, a large number of animals were randomly selected to study pregnant women and their diets.
Abstract
OBJECTIVE: To determine how diet of the mother in pregnancy influences the blood pressure of the offspring in adult life. DESIGN: A follow up study of men and women born during 1948-1954 whose mothers had taken part in a survey of diet in late pregnancy. SETTING: Aberdeen, Scotland. POPULATION: Two hundred and fifty-three men and women born in Aberdeen Maternity Hospital. MAIN OUTCOME MEASURE: Systolic and diastolic blood pressure. RESULTS: The relations between the diet of mothers and their offsprings' blood pressure were complex. When the mothers' intake of animal protein was less than 50 g daily, a higher carbohydrate intake was associated with a higher blood pressure in the offspring (a 100 g increase in carbohydrate being associated with a 3 mmHg increase in systolic pressure (P = 0.02)). At daily animal protein intakes above 50 g, lower carbohydrate intake was associated with higher blood pressure (a 100 g decrease in carbohydrate being associated with an 11 mmHg rise in systolic blood pressure (P = 0.004)). These increases in blood pressure were associated with decreased placental size. CONCLUSION: Mothers' intakes of animal protein and carbohydrate in late pregnancy may influence their offsprings' adult blood pressure. This may be mediated through effects on placental growth.
Keywords
MedicineNursing
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