The dual effect of membrane potential on sodium conductance in the giant axon of <i>Loligo</i>
The Journal of PhysiologyPublished 28 April 1952Open access
A. L. Hodgkin, A. F. Huxley
Citations1,589
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This paper contains a further account of the electrical properties of the giant axon of Loligo and deals with the 'inactivation' process which gradually reduces sodium permeability after it has undergone the initial rise associated with depolarization.
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Materials ScienceNeuroscience
The Journal of PhysiologyA quantitative description of membrane current and its application to conduction and excitation in nerve
23,234 Citations1952A. L. Hodgkin, A. F. Huxley
This article concludes a series of papers concerned with the flow of electric current through the surface membrane of a giant nerve fibre by putting them into mathematical form and showing that they will account for conduction and excitation in quantitative terms.
The Journal of PhysiologyCurrents carried by sodium and potassium ions through the membrane of the giant axon of <i>Loligo</i>
2,474 Citations1952A. L. Hodgkin, A. F. Huxley
The identity of the ions which carry the various phases of the membrane current is chiefly concerned with sodium ions, since there is much evidence that the rising phase of the action potential is caused by the entry of these ions.
The Journal of PhysiologyMeasurement of current‐voltage relations in the membrane of the giant axon of <i>Loligo</i>
1,715 Citations1952A. L. Hodgkin, A. F. Huxley +1 more
The importance of ionic movements in excitable tissues has been emphasized by a number of recent experiments which are consistent with the theory that nervous conduction depends on a specific increase in permeability which allows sodium ions to move from the more concentrated solution outside a nerve fibre to the more dilute solution inside it.
Biological reviews/Biological reviews of the Cambridge Philosophical SocietyTHE IONIC BASIS OF ELECTRICAL ACTIVITY IN NERVE AND MUSCLE
962 Citations1951A. L. Hodgkin
This hypothesis is applied to the phenomena of subthreshold activity, accomodation and oscillatory behaviour and it is suggested that both permeability changes vary with membrane potential in a graded but reversible manner.