Cancer mortality in Europe, 2000–2004, and an overview of trends since 1975
Annals of OncologyPublished 1 December 2009Open access
Carlo La Vecchia, Cristina Bosetti, F Lucchini, Paola Bertuccio, Eva Negri, Peter Boyle
Citations562
SJR quartileQ1
SJR score19.07
SNIP10.48
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Favourable trends were observed for testicular cancer, Hodgkin lymphomas, leukaemias, and other neoplasms amenable to treatment, though the reductions were still appreciably smaller in eastern Europe.
Abstract
This updated analysis of cancer mortality in Europe showed a persistent favourable trend over the last years.
Keywords
Medicine
Cancer Incidence in Five Continents
8,539 Citations1970Richard Doll, C. S. Muir +1 more
Statistics in MedicinePermutation tests for joinpoint regression with applications to cancer rates
6,069 Citations2000Hyune-Ju Kim, Michael P. Fay +2 more
A joinpoint regression model is applied to describe continuous changes in the recent trend and the grid-search method is used to fit the regression function with unknown joinpoints assuming constant variance and uncorrelated errors.
Choice Reviews OnlineFood, nutrition, physical activity, and the prevention of cancer: a global perspective
5,391 Citations2008Michael Marmot, Tola Atinmo +19 more
The extent to which food, nutrition, physical activity, and body composition modify the risk of cancer, and to specify which factors are most important, is explored.
JNCI Journal of the National Cancer InstituteThe Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today
3,909 Citations1981Richard Doll, Richard Peto
Evidence that the various common types of cancer are largely avoidable diseases is reviewed and suggests that, apart from cancer of the respiratory tract, the types ofcancer that are currently common are not peculiarly modern diseases and are likely to depend chiefly on some long-established factor(s).
The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today
3,518 Citations1983Richard Peto
Cancer Epidemiology and Prevention
3,382 Citations2006
This is an account of cancer epidemiology has been expanded and contains new material on cancer biology, molecular epidemiology, preventive strategies and specific types and sites of cancer.
New England Journal of MedicineMortality Results from a Randomized Prostate-Cancer Screening Trial
2,917 Citations2009Gerald L. Andriole, E. David Crawford +22 more
After 7 to 10 years of follow-up, the rate of death from prostate cancer was very low and did not differ significantly between the two study groups.
New England Journal of MedicineBortezomib plus Melphalan and Prednisone for Initial Treatment of Multiple Myeloma
1,904 Citations2008Jesús F. San Miguel, Rudolf Schlag +19 more
New England Journal of MedicineRadical Prostatectomy versus Watchful Waiting in Early Prostate Cancer
1,896 Citations2011Anna Bill‐Axelson, Lars Holmberg +13 more
Radical prostatectomy was associated with a reduction in the rate of death from prostate cancer, and men with extracapsular tumor growth may benefit from adjuvant local or systemic treatment.
Annals of OncologyCancer incidence and mortality in Europe, 2004
1,211 Citations2005Peter Boyle, Jacques Ferlay
Estimates of the cancer burden in Europe in 2004 are presented, including data for the (25 Member States) European Union, to make a concerted attack on the big killers: lung, colorectal, breast and stomach cancer.
Epidemiologic ReviewsHelicobacter Pylori: Epidemiology and Routes of Transmission
1,127 Citations2000Línda Morris Brown
Overall, inadequate sanitation practices, low social class, and crowded or high-density living conditions seem to be related to a higher prevalence of H. pylori infection, which suggests that poor hygiene and crowded conditions may facilitate transmission of infection among family members and is consistent with data on intrafamilial and institutional clustering of the bacterium.
New England Journal of MedicineRadical Prostatectomy versus Watchful Waiting in Early Prostate Cancer
1,119 Citations2005Anna Bill‐Axelson, Lars Holmberg +12 more
JAMAAndrogen Deprivation Therapy for Prostate Cancer
1,055 Citations2005Nima Sharifi
Androgen deprivation therapy has clear roles in the management of advanced prostate cancer and high-risk localized disease and the benefits of ADT in other settings need to be weighed carefully against substantial risks and adverse effects on quality of life.
JNCI Journal of the National Cancer InstituteAnnual Report to the Nation on the Status of Cancer, 1975–2005, Featuring Trends in Lung Cancer, Tobacco Use, and Tobacco Control
953 Citations2008Ahmedin Jemal, Michael J. Thun +10 more
Although the decrease in overall cancer incidence and death rates is encouraging, large state and regional differences in lung cancer trends among women underscore the need to maintain and strengthen many state tobacco control programs.
International Journal of CancerGallbladder cancer worldwide: Geographical distribution and risk factors
935 Citations2006G. Randi, Silvia Franceschi +1 more
Differences in incidence ratios point to variations in gallbladder cancer aetiology in different populations, but interventions able to prevent obesity, cholecystitis and gallstone formation should be assessed.
The LancetOvarian cancer and oral contraceptives: collaborative reanalysis of data from 45 epidemiological studies including 23 257 women with ovarian cancer and 87 303 controls
786 Citations2008Valerie Beral
It is suggested that oral contraceptives have already prevented some 200,000 ovarian cancers and 100,000 deaths from the disease, and that over the next few decades the number of cancers prevented will rise to at least 30,000 per year.
European Journal of CancerRecent trends of cancer in Europe: A combined approach of incidence, survival and mortality for 17 cancer sites since the 1990s
756 Citations2008Henrike E. Karim‐Kos, Esther de Vries +4 more
Cancer prevention and management in Europe is moving in the right direction through the combination of earlier detection, better access to care and improved treatment, especially in the domain of female smoking prevalence and the emerging obesity epidemic.
CancerThe annual report to the nation on the status of cancer, 1973-1997, with a special section on colorectal cancer
749 Citations2000Lynn A. G. Ries, Phyllis A. Wingo +7 more
This annual report to the nation addresses progress in cancer prevention and control in the U.S. with a special section on colorectal cancer.
CancerIARC Handbooks of Cancer Prevention
747 Citations2003Stephen A. Feig
The International Agency for Research on Cancer conducts a programme of research concentrating particularly on the epidemiology of cancer and the study of potential carcinogens in the human environment.
JNCI Journal of the National Cancer InstituteAnnual Report to the Nation on the Status of Cancer (1973 Through 1998), Featuring Cancers With Recent Increasing Trends
744 Citations2001Holly L. Howe, Phyllis A. Wingo +5 more
Overall cancer incidence and death rates continued to decline in the United States and future progress will require sustained improvements in cancer prevention, screening, and treatment.
American Journal of Public HealthAccuracy of cancer death certificates and its effect on cancer mortality statistics.
706 Citations1981C Percy, Edward J. Stanek +1 more
A study to determine the accuracy of cancer mortality data was done using cancer deaths occurring during 1970 and 1971 in eight of the nine areas included in the Third National Cancer Survey (TNCS).
PubMedObesity, alcohol, and tobacco as risk factors for cancers of the esophagus and gastric cardia: adenocarcinoma versus squamous cell carcinoma.
520 Citations1995Thomas L. Vaughan, Scott Davis +2 more
Body mass index was inversely associated with risk, whereas for adenocarcinoma, the highest risk was observed among persons who were in the highest decile of body mass index, Whereas for squamous cell carcinoma, body mass indices were inverselyassociated with risk.
International Journal of CancerRenal cell carcinoma in relation to cigarette smoking: Meta-analysis of 24 studies
515 Citations2004Jay D. Hunt, Olga L. van der Hel +3 more
Inhaled tobacco smoke is clearly implicated in the etiology of RCC, with a strong dose‐dependent increase in risk associated with numbers of cigarettes smoked per day and a substantial reduction in risk for long‐term former smokers.
New England Journal of MedicineBreast-Cancer Screening
506 Citations2011Ellen Warner
Although there is still considerable debate over the age and interval at which women should undergo screening, the primary care physician's recommendation is the single most important factor and will certainly lead to a higher screening rate for women in the greater at-risk age groups.
New England Journal of MedicineBreast Cancer after Use of Estrogen plus Progestin in Postmenopausal Women
468 Citations2009Rowan T. Chlebowski, Lewis H. Kuller +15 more
The increased risk of breast cancer associated with the use of estrogen plus progestin declined markedly soon after discontinuation of combined hormone therapy and was unrelated to changes in frequency of mammography.
Oral OncologyEpidemiology and prevention of oral cancer
440 Citations1997Carlo La Vecchia, Alessandra Tavani +4 more
The possibility of human papillomavirus involvement in the aetiology of cancer of the oral cavity and pharynx is overviewed, and the independent role of alcohol and tobacco and their interaction on oral carcinogenesis is discussed.
JNCI Journal of the National Cancer InstituteBreast Cancer Incidence, 1980 2006: Combined Roles of Menopausal Hormone Therapy, Screening Mammography, and Estrogen Receptor Status
437 Citations2007Andrew G. Glass, James V. Lacey +2 more
From 1980 through 2006, quantitative and qualitative trends in breast cancer incidence rates, particularly for ER+ tumors, parallel major changes in patterns of mammography screening and use of menopausal hormone therapy.
International Journal of CancerTime trends incidence of both major histologic types of esophageal carcinomas in selected countries, 1973–1995
430 Citations2002A. Paloma Vizcaino, Vı́ctor Moreno +2 more
The results indicate that the incidence rate of squamous cell carcinoma of the esophagus has been relatively stable in most of the countries analyzed, although increasing trends were observed in Denmark and the Netherlands among men and in Canada, Scotland and Switzerland among women.
Alcohol and AlcoholismComparing alcohol consumption in central and eastern Europe to other European countries
385 Citations2007Svetlana Popova, Jürgen Rehm +2 more
The population drinking levels found in central and eastern Europe are linked with higher levels of detrimental health outcomes and known effective and cost-effective programs to reduce levels of risky drinking should be implemented, which may lead to a reduction of alcohol-attributable burden of disease.
Oxford Textbook of Public Health
377 Citations2009Roger Detels, McEwen, James +2 more
This book discusses the development of the discipline of public health as well as the methods and techniques used in the promotion and management of health in the developing world.
International Journal of CancerThe burden of cancer attributable to alcohol drinking
326 Citations2006Paolo Boffetta, Mia Hashibe +3 more
Although the authors' estimates are based on simplified assumptions, the burden of alcohol‐associated cancer appears to be substantial and needs to be considered when making public health recommendations on alcohol drinking.
Annals of OncologyEuropean Code Against Cancer and scientific justification: third version (2003)
307 Citations2003Peter Boyle, Philippe Autier +40 more
P. Boyle*, P. Boffetta, J. Burn, H. Burns, L. Levi, G. McVie, P. Quinn, M. Richards, U. Scully, E. Storm,M.
Cancer Causes & ControlRisk factors for thyroid cancer: an epidemiological review focused on nutritional factors
287 Citations2008Luigino Dal Maso, Cristina Bosetti +2 more
At present, the only recognized measures for reducing TC risk is to avoid ionizing radiation and iodine deficiency, particularly in childhood and young women, and to increase vegetable consumption.
HepatologyTrends in mortality from hepatocellular carcinoma in Europe, 1980‐2004†
277 Citations2008Cristina Bosetti, Fabio Levi +4 more
Favorable trends were observed in several European countries mainly over the last decade, particularly in women and in young adults, whereas they were more favorable at age 20‐44 years in both sexes.
The Lancet OncologyProstate-cancer mortality in the USA and UK in 1975–2004: an ecological study
271 Citations2008Simon M. Collin, Richard M. Martin +9 more
The striking decline in prostate-cancer mortality in the USA compared with the UK in 1994-2004 coincided with much higher uptake of PSA screening in the America, and Explanations for the different trends in mortality include the possibility of an early effect of initial screening rounds on men with more aggressive asymptomatic disease in theUSA, different approaches to treatment in the two countries, and bias related to the misattribution of cause of death.
Nature Clinical Practice UrologyMechanisms of Disease: the epidemiology of bladder cancer
264 Citations2006Claudio Pelucchi, Cristina Bosetti +3 more
Mortality from bladder cancer has shown downward trends over the last 2 decades in several western European countries (albeit 10–15 years later than similar trends in the US), but is still increasing in some eastern European countries.
European Journal of CancerCutaneous malignant melanoma in Europe
263 Citations2004Esther de Vries, J.W.W. Coebergh
Evidence on an association between sun bed use and melanoma is inconclusive, but seems to point to a slightly increased risk associated with sunbed use.
Annals of OncologyEpidemiology of biliary tract cancers: an update
248 Citations2008Giorgia Randi, Matteo Malvezzi +5 more
The decreasing BTC mortality trends essentially reflect more widespread and earlier adoption of cholecystectomy in several countries, since gallstones are the major risk factor for BTC.
British Journal of UrologyThe changing pattern of kidney cancer incidence and mortality in Europe
247 Citations2008Fabio Levi, Jacques Ferlay +5 more
To update trends in kidney cancer mortality in 32 European countries and the European Union as a whole, as mortality from kidney cancer has increased throughout Europe until the late 1980s or early 1990s, and has tended to stabilise or decline thereafter.
International Journal of CancerTrends in oesophageal cancer incidence and mortality in Europe
237 Citations2007Cristina Bosetti, Fabio Levi +6 more
To monitor recent trends in mortality from oesophageal cancer in 33 European countries, the data provided by the World Health Organization over the last 2 decades were analyzed using joinpoint regression and Squamous‐cell carcinoma remained the prevalent histological type in southern Europe.
The Lancet OncologyWhy is breast-cancer mortality declining?
236 Citations2003Ismail Jatoi, Anthony B. Miller
It is argued that although some of the decline in breast-cancer mortality is due to a reduction in Breast-cancer risk, most of it can probably be attributed to adjuvant systemic therapy and the earlier detection of palpable tumours.
Journal of HepatologyWorldwide mortality from cirrhosis: An update to 2002
233 Citations2007Cristina Bosetti, Fabio Levi +4 more
Age-standardized (world standard) cirrhosis mortality rates per 100,000 were computed for 41 countries worldwide over the period 1980-2002 using data from the WHO mortality database, showing favourable trends in most countries of the world.
British Journal of CancerWorldwide variation in the relative importance of hepatitis B and hepatitis C viruses in hepatocellular carcinoma: a systematic review
222 Citations2007Syed Ahsan Raza, Gary M. Clifford +1 more
A predominance of HBsAg was found in HCCs from most Asian, African and Latin American countries, but anti-HCV predominated in Japan, Pakistan, Mongolia and Egypt.
CancerTrends in prostate cancer mortality among black men and white men in the United States
184 Citations2003Kenneth C. Chu, Robert E. Tarone +1 more
Investigation of possible mechanisms for the declining prostate cancer mortality rates in the United States found that the rates declined sharply after 1991 in white men and declined after 1992 in black men.
International Journal of CancerCancer mortality in Europe, 1995–1999, and an overview of trends since 1960
180 Citations2004Fabio Levi, Franca Lucchini +3 more
The overall favorable pattern of cancer mortality over recent years is largely driven by the decline of tobacco‐related cancer mortality in men, however, important components of the trends are also the persistence of substantial falls in gastric cancer, mainly in Russia and Eastern Europe, and the recent decline in intestinal cancer in both sexes and of breast cancer in women.
RePEc: Research Papers in EconomicsOxford Textbook of Public Health
171 Citations2011Roger Detels, Robert Beaglehole +2 more
British Journal of CancerKaposi sarcoma incidence in the Swiss HIV Cohort Study before and after highly active antiretroviral therapy
167 Citations2008and the Swiss HIV Cohort Study, Silvia Franceschi +11 more
Men having sex with men and birth in Africa or the Middle East were associated with KS in both non-users and users of HAART but the risk pattern by CD4 cell count differed and only very low CD4cell count at enrolment or at HAART initiation were significantly associated withKS among HAART users.
The Lancet OncologyCarcinogenicity of household solid fuel combustion and of high-temperature frying
165 Citations2006Kurt Straíf, Robert A. Baan +4 more
Indoor emissions from household combustion of coal are “carcinogenic to humans (Group 1)”, and inhalation of emissions from coal, burned under conditions similar to those in Xuan Wei, increased the incidence of various types of malignant lung tumours in male and female Kunming mice and of squamous-cell carcinomas inmale and female Wistar rats.
International Journal of CancerOvarian cancer in Europe: Cross-sectional trends in incidence and mortality in 28 countries, 1953-2000
159 Citations2004Freddie Bray, Anja H. Loos +2 more
Recent trends in ovarian cancer have led to a leveling of rates across various areas of the continent, although a 2.5‐fold variation was still observed in the late 1990s between the highest mortality rate of 9.3/100,000 in Denmark and the lowest one of 3.6 in Portugal.
Annals of OncologyCancer mortality in the European Union, 1970–2003, with a joinpoint analysis
158 Citations2008Cristina Bosetti, Paola Bertuccio +4 more
In both sexes, mortality declined in 1970-2003 for stomach cancer and for a few cancers amenable to treatment, and shows favorable patterns over recent years in both sexes.
British Journal of UrologyDeclining mortality from bladder cancer in Europe
135 Citations2007Jacques Ferlay, Giorgia Randi +5 more
To update trends in bladder cancer mortality in 32 European countries and the European Union as a whole, as mortality has been declining in most of Western Europe since the early 1990s, but it has still been increasing in several central and eastern European countries up to the mid 1990s.
International Journal of CancerA Joinpoint regression analysis of long‐term trends in cancer mortality in Japan (1958–2004)
135 Citations2008Dongmei Qiu, Kota Katanoda +2 more
An effective cancer control program including prevention, early detection and treatment should be implemented to further reduce the cancer mortality, particularly for cancer sites that show higher mortality rates or increasing trends.
JNCI Journal of the National Cancer InstituteAdjuvant Chemotherapy in Completely Resected Gastric Cancer: A Randomized Phase III Trial Conducted by GOIRC
132 Citations2008Francesco Di Costanzo, Silvia Gasperoni +14 more
The results failed to provide proof of an effect of adjuvant chemotherapy with PELF on overall survival or disease-free survival and the estimated effect of chemotherapy (10% reduction in the hazard of death or relapse) is modest and consistent with the results of meta-analyses of adjUvant chemotherapy without platinum agents.
European Journal of CancerCervical cancer mortality in young women in Europe
131 Citations2000Fabio Levi, F Lucchini +3 more
The declines registered in cervical cancer mortality in young women were largely due to screening, and the persisting variations in mortality across Europe underline the importance of the adoption of organised screening programmes, with specific urgency in Eastern Europe.
European Journal of Cancer PreventionMonitoring the decrease in breast cancer mortality in Europe
126 Citations2005Fabio Levi, Cristina Bosetti +3 more
The fall in breast cancer mortality observed in most European countries over the last decade has to be attributed to earlier detection and improved treatment, although the definite reasons for the different trends in various countries remain at least in part unclear.
Cancer of the Pancreas
122 Citations2006Kristin E. Anderson, Thomas M. Mack +1 more
Breast Cancer Research and TreatmentPopulation screening and intensity of screening are associated with reduced breast cancer mortality: evidence of efficacy of mammography screening in Australia
120 Citations2007David Roder, N. Houssami +8 more
Participation in screening was associated with a breast-cancer mortality reduction of between 30 and 41%, depending on assumptions about screening self-selection bias, and a downward mortality risk by recency of last screen prior to cancer diagnosis, and frequency of recent screening, is consistent with a screening effect.
International Journal of CancerTime trends of breast cancer survival in Europe in relation to incidence and mortality
119 Citations2006Milena Sant, Silvia Francisci +4 more
In most countries survival increased, indicating a real advantage for patients when accompanied by decreasing or stable mortality, and attributable to improved cancer care (Sweden, UK, France, Italy and Spain); in Finland, the Netherlands and Denmark, increasing mortality and incidence indicate increasing breast cancer risk.
European Journal of CancerDescription of the national situation of cervical cancer screening in the member states of the European Union
116 Citations2009Ahti Anttila, Guglielmo Ronco
This report up-dates information on the national situation of cervical cancer screening in the member states of the European Union and highlights differences in the health care and other components.
Annals of OncologyDietary intake of selected micronutrients and gastric cancer risk: an Italian case-control study
105 Citations2008Claudio Pelucchi, Irene Tramacere +4 more
The data support a favourable effect on gastric cancer of vitamin E and selected carotenoids and a detrimental effect of sodium even at intermediate levels of intake.
European Journal of CancerLong-term survival expectations of cancer patients in Europe in 2000–2002
103 Citations2008Hermann Brenner, Silvia Francisci +8 more
Detailed period estimates of 5- and 10-year relative survival by cancer site, country, sex and age for calendar years 2000-2002 show that relative survival was also better in female than in male patients and decreased with age for most cancer sites.
Annals of OncologyBurden of cervical cancer in the 27 member states of the European Union: estimates for 2004
95 Citations2007Marc Arbyn, Philippe Autier +1 more
The addition of Bulgaria and Romania makes the west–east gradient even stronger than before the recent expansion of the EU, and makes clear that more support of European public health authorities has to be allocated to the East European member states to help Annals of Oncology letters to the editor.
JNCI Journal of the National Cancer InstituteIncidence Rates of Intra- and Extrahepatic Cholangiocarcinomas in Denmark From 1978 Through 2002
89 Citations2007Peter Jepsen, Hendrik Vilstrup +3 more
The Danish incidence rates of intra- and extrahepatic cholangiocarcinomas were nearly identical throughout the study period, and the decreasing incidence rates cannot be explained by time trends in known risk factors.
Annals of OncologyLung cancer mortality in European women: recent trends and perspectives
82 Citations2005Cristina Bosetti, Fabio Levi +3 more
Although female lung cancer mortality is still increasing in most European countries, the more favorable trends in young women over recent calendar years suggest that if effective interventions to control tobacco smoking in women are implemented, the lung cancer epidemic in European women will not reach the levels observed in the USA.
International Journal of CancerExcess of cancers in Europe: A study of eleven major cancers amenable to lifestyle change
80 Citations2006Isabelle Soerjomataram, Esther de Vries +2 more
Of the 1.4 million adult cases of selected cancers and countries within this study, 363,000 (59%) cancers in males and 326,000 cancers in females were hypothetically avoidable, and the proportion was largest in Hungary and among women, in Belgium.
Annals of OncologyMonitoring falls in gastric cancer mortality in Europe
78 Citations2004Fabio Levi, F Lucchini +4 more
Steady and persisting falls in rates were observed, and the fall between 1980 and 1999 was approximately 50% in the EU, 45% in eastern Europe and 40% in Russia, since rates were much higher, in absolute terms.
International Journal of CancerIncidence and mortality from non‐Hodgkin lymphoma in Europe: The end of an epidemic?
78 Citations2008Cristina Bosetti, Fabio Levi +4 more
The epidemic of NHL observed during the second half of the 20th century has now started to level off in Europe as in other developed areas of the world.
PubMedThe interpretation of time trends.
74 Citations1994Muir Cs, Jr Jf Fraumeni +1 more
The requirements for valid comparison over time of cancer incidence and mortality are given and future work is likely to give much greater emphasis to subsite and histological type, information that is difficult to publish routinely.
Annals of OncologyEpidemiology, treatment and chemoprevention in colorectal cancer
72 Citations2003P. Rougier, Emmanuel Mitry
Several new cytotoxic agents show promise in CRC, including irinotecan, which extends survival both when used as a single agent second-line versus best supportive care alone, and when added to 5-FU/folinic acid in the first-line setting.
British Journal of CancerA cohort study of antihypertensive treatments and risk of renal cell cancer
71 Citations2005Jon P. Fryzek, Aslak Harbo Poulsen +4 more
The elevated RRs for RCC among users of AHTs compared with the general population are unlikely to be causal, but rather reflect confounding due to failure to control for pre-existing hypertension, and protopathic bias, due to the presence of hypertension as an early sign of kidney disease.
PancreasPancreatic Cancer Mortality in Europe: The Leveling of an Epidemic
60 Citations2003Fabio Levi, Franca Lucchini +2 more
This analysis first documents a leveling of pancreatic cancer mortality in Europe, after decades of steady rises, partly or largely attributable to the decline in smoking, at least in men, but other factors, including mainly nutrition and diet, may also have played some role on these trends.
European Journal of Cancer PreventionOral contraceptives and ovarian cancer: an update, 1998–2004
59 Citations2006Carlo La Vecchia
The reduced risk among OC users is observed in women without or with family history or genetic predisposition to ovarian cancer and for most histological types of epithelial ovarian cancer although the pattern of risk is less consistent for mucinous than for other types.
European Journal of CancerConverging patterns of colorectal cancer mortality in Europe
58 Citations2005Esteve Fernández, Carlo La Vecchia +4 more
A favourable pattern in colorectal cancer mortality for both genders was observed in most European countries from the 1990s onwards, and deaths are likely to decline further in Europe in the current decade.
Cancer Causes & ControlSun Exposure, Phenotypic Characteristics, and Cutaneous Malignant Melanoma. An Analysis According to Different Clinico-Pathological Variants and Anatomic Locations (Italy)
56 Citations2005Luigi Naldi, Andrea Altieri +4 more
A higher level of education and sunburn episodes in early childhood appeared to be more strongly related to SSM than to other variants, and total number of nevi was the major risk factor associated with all melanoma variants and locations.
Breast Cancer ResearchExpert Group: IARC Handbooks of Cancer Prevention. Vol.7: Breast Cancer Screening. Lyon, France: IARC; 2002. 248pp.
55 Citations2003Robert A. Smith
The IARC Handbook on Breast Cancer Screening concludes that mammography is effective in reducing breast cancer mortality, but like other screening tests, has a number of limitations.
CA A Cancer Journal for CliniciansProstate Cancer: Current Evidence Weighs Against Population Screening
54 Citations2009Peter Boyle, O. W. Brawley
The Quebec study was proclaimed as the first randomized trial to demonstrate the efficacy of screening for prostate cancer and reported a 47% higher rate of diagnosis in screened men than in controls and a reanalysis strongly suggested that the original findings were significantly affected by selection bias.
Melanoma ResearchMortality from cutaneous malignant melanoma in Europe. Has the epidemic levelled off?
53 Citations2004Cristina Bosetti, Carlo La Vecchia +4 more
The particularly favourable trends in young people suggest that a further decline in mortality from CMM in Europe is likely to occur within the next few years, and further evidence of an improvement of CMM mortality trends in recent years in several European countries is provided.
Cutaneous and Ocular Melanoma
51 Citations2006Stephen B. Gruber, Bruce K. Armstrong
Recent results in cancer research/Recent Results in Cancer ResearchRelative Value of Incidence and Mortality Data in Cancer Research
50 Citations1989Peter Boyle
From examination of the reliability and quality of mortality data, it would appear that international variation in the quality of death certification and in the application of internationally agreed rules for selecting the underlying cause of death may in themselves be enough to vitiate the argument that there is significantinternational variation in cancer levels or to indicate variation where none in reality may exist.
The ProstateLeveling of prostate cancer mortality in Western Europe
45 Citations2004Fabio Levi, Franca Lucchini +3 more
Mortality from prostate cancer (CaP) has increased throughout Europe until the early 1990s, and trends in 24 countries, the European Union, six selected Central and Eastern European countries, and the Russian Federation have been updated to 1999.
International Journal of EpidemiologyCancer mortality in Russia and Ukraine: validity, competing risks and cohort effects
45 Citations1999Vladimir M. Shkolnikov
An analysis of trends and patterns in cancer mortality in Russia and examines four possible explanations for its recent fall: changes in data collection; cohort effects; competing mortality from other causes of death; and improvements in health care.
LeukemiaTrends in mortality from leukemia in subsequent age groups
44 Citations2000Fabio Levi, F Lucchini +3 more
Leukemia mortality rates in the USA and Japan started from different values, but were similar to those of the EU in the late 1990s, indicating that the impact of therapeutic advancements has been comparable in developed areas of the world.
British Journal of CancerTobacco smoking, body mass index, hypertension, and kidney cancer risk in central and eastern Europe
43 Citations2008Paul Brennan, Olga van der Hel +12 more
An increased risk for self-reported hypertension and for obesity is found in four central European countries, with 1097 incident cases and 1476 controls of kidney cancer.
International Journal of CancerTrends in laryngeal cancer mortality in Europe
42 Citations2006Cristina Bosetti, Werner Garavello +4 more
Despite recent declines, the persistence of a wide variability in male laryngeal cancer mortality indicates that there is still ample scope for prevention of larynGEal cancer in Europe.
European Journal of CancerPerspectives in cancer chemotherapy
41 Citations2001Silvio Garattini, Carlo La Vecchia
This article will attempt to review the achievements of cancer treatment, covering the therapeutic results, in general, and the role of chemotherapy, in particular, and some of the most promising ways of prevention and therapeutic strategies now being or shortly to be developed are considered.
European Journal of Cancer PreventionEuropean studies on long-term exposure to ambient particulate matter and lung cancer
41 Citations2008Silvano Gallus, Eva Negri +4 more
European studies of PM exposure and lung cancer do not show a clear association, but uncertainties remain for the measurement of exposure and latency.
Leukemia ResearchTrends in mortality from non-Hodgkin’s lymphomas
40 Citations2002Fabio Levi, Franca Lucchini +2 more
Trends in death certification rates from non-Hodgkin's lymphomas (NHL) were analyzed on the basis of the World Health Organization database over the period 1969-1998 and upward trends were greater in the USA, whose rates approached 6/100,000 males and 4/ 100,000 females in the late 1990s, and were observed in Japan, too.
International Journal of CancerOesophageal adenocarcinoma: A paradigm of mechanical carcinogenesis?
37 Citations2002Carlo La Vecchia, Eva Negri +2 more
It is suggested that the increase in frequency of reflux and the 2 associated forms of cancer can be explained by growing abdominal pressure brought about by increasing central obesity, most common among men, and sedentary lifestyle, including car use.
CancerTesticular cancer mortality in the Americas, 1980–2003
32 Citations2007Paola Bertuccio, Matteo Malvezzi +5 more
The objective of the study was to compare death rates and trends over the 1980–2003 period in all the American countries that provide data.
International Journal of CancerTesticular cancer mortality in Eastern Europe
30 Citations2003Fabio Levi, Franca Lucchini +3 more
The authors thank the Cancer Epidemiology Unit and Cancer Registries of Vaud and Neuchâtel and the European Institute of Oncology for their assistance in this research.
European Journal of Cancer PreventionComparative descriptive epidemiology of oral and oesophageal cancers in Europe
25 Citations1996Eva Negri, Carlo La Vecchia +4 more
The mortality rates of cancers of the oral cavity and oesophagus show several analogies, as expected from their relation to tobacco and alcohol; but some discrepancies suggest that other, less well-identified, factors may also influence their rates and trends in Europe.
Annals of OncologyThe recent decline in mortality from Hodgkin lymphomas in central and eastern Europe
23 Citations2008Cristina Bosetti, Fabio Levi +4 more
The present work confirms the persistent declines in HL mortality in western European countries, and shows favorable patterns over more recent calendar years in central/eastern ones, where rates are still at levels observed in western Europe in the early 1990s.
European Journal of CancerTrends in cancer mortality at age 15 to 24 years in Europe
20 Citations2003Fabio Levi, F Lucchini +2 more
Overall, there was a decrease in total cancer mortality of approximately 40% for both sexes over the period of 1965-1998, and the degree of improvement was similar in Japan and the USA, but was less in Eastern European countries.
International Journal of CancerTrends in colorectal cancer mortality in Japan, 1970–2000
17 Citations2004Cristina Bosetti, Matteo Malvezzi +4 more
A comparative study of trends in colorectal cancer incidence in Miyagi Prefecture of Japan and Connecticut, USA from 1959 to 1992 showed substantial rises for both colon and rectal cancer in Japan.
New England Journal of MedicineTreatment of Myeloma — Are We Making Progress?
15 Citations2008Brian G.M. Durie
The benefit of combining bortezomib with melphalan plus prednisone, as compared with melPHalan plus Prednisone alone, as initial therapy as initial treatment for central giant cell granuloma is described.
Annals of PharmacotherapyOncology: Treatment of Multiple Myeloma in the Targeted Therapy Era
12 Citations2009Ayman Saad, Manish Sharma +1 more
Thalidomide, lenalidomides, or bortezomib in combination with dexamethasone have replaced traditional chemotherapy such as melphalan, doxorubicin, and vincristine as initial therapy of patients with MM who are eligible for stem-cell transplantation.
CancerIncidence of multiple myeloma in Olmsted County, Minnesota
10 Citations2005Fabio Levi, Van‐Cong Te +2 more
European Journal of CancerCalcium channel blockers, verapamil and cancer risk
9 Citations2002Carlo La Vecchia, Cristina Bosetti
The results of the Rotterdam Study are in broad agreement with those of major studies providing data on CCB and cancer risk, indicating some excess risk of kidney cancer, but no or a modest excess of other cancer sites [3,8–11].
…