Successful Treatment of Giggle Incontinence With Methylphenidate

It is suggested that giggle incontinence is a centrally mediated and likely hereditary disorder that may share a common pathophysiological basis with the narcolepsy/cataplexy syndrome.

Abstract

No AccessJournal of UrologyIncontinence1 Aug 1996Successful Treatment of Giggle Incontinence With Methylphenidate Phyllis K. Sher and Yuri Reinberg Phyllis K. SherPhyllis K. Sher and Yuri ReinbergYuri Reinberg View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)65776-8AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Giggle incontinence, the second most common type of childhood enuresis unrelated to disease, is notoriously difficult to treat. However, the association of laughter or emotion precipitated alteration of muscle tone is suggestive of a functional relationship to cataplexy, a part of the narcoleptic syndrome complex that may respond to stimulant medication. Materials and Methods: Two boys and 5 girls (mean age 10.9 years) with giggle incontinence, a positive family history of giggle incontinence (4 patients) and no evidence of urological disease were treated with methylphenidate for 1 to 5 years. Results: All patients responded positively with complete cessation of enuresis to varying dose schedules of methylphenidate. Conclusions: These results suggest that giggle incontinence is a centrally mediated and likely hereditary disorder that may share a common pathophysiological basis with the narcolepsy/cataplexy syndrome. References 1 : Disorders of micturition and defecation. In: Pediatric Neurology: Principles and Practice. Edited by . St. Louis: C. V. Mosby Co.1994: 271. chapt. 20. Google Scholar 2 : Pediatric urinary incontinence Urol. Clin. N. Amer.1991; 18: 283. Google Scholar 3 : Day wetting. Ped. Nephrol.1990; 4: 178. Google Scholar 4 : Urinary incontinence in children: suggestions for definitions and terminology. Scand. J. Urol. 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Google Scholar From the Department of Neurology, Division of Pediatric Neurology, University of Minnesota Medical School, Minneapolis and Department of Urology, St. Paul-Ramsey Medical Center, St. Paul, Minnesota.© 1996 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byvon Gontard A, Heron J and Joinson C (2011) Family History of Nocturnal Enuresis and Urinary Incontinence: Results From a Large Epidemiological StudyJournal of Urology, VOL. 185, NO. 6, (2303-2307), Online publication date: 1-Jun-2011.Berry A, Zderic S and Carr M (2009) Methylphenidate for Giggle IncontinenceJournal of Urology, VOL. 182, NO. 4S, (2028-2032), Online publication date: 1-Oct-2009.Richardson I and Palmer L (2009) Successful Treatment for Giggle Incontinence With BiofeedbackJournal of Urology, VOL. 182, NO. 4S, (2062-2066), Online publication date: 1-Oct-2009.CHANDRA M, SAHARIA R, SHI Q and HILL V (2018) Giggle Incontinence in Children: A Manifestation of Detrusor InstabilityJournal of Urology, VOL. 168, NO. 5, (2184-2187), Online publication date: 1-Nov-2002.von GONTARD A, SCHAUMBURG H, HOLLMANN E, EIBERG H and RITTIG S (2018) THE GENETICS OF ENURESIS: A REVIEWJournal of Urology, VOL. 166, NO. 6, (2438-2443), Online publication date: 1-Dec-2001. Volume 156Issue 2SAugust 1996Page: 656-658 Advertisement Copyright & Permissions© 1996 by American Urological Association, Inc.MetricsAuthor Information Phyllis K. Sher More articles by this author Yuri Reinberg More articles by this author Expand All Advertisement PDF downloadLoading ...