Superoxide anion production by the autoxidation of cytochrome P450cam
Biochemical and Biophysical Research CommunicationsPublished 1 November 1974
Stephen G. Sligar, John D. Lipscomb, Peter G. Debrunner, I. C. Gunsalus
Citations140
SJR quartileQ2
SJR score0.75
SNIP0.56
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TL;DR
Chemiluminescence occurs on autoxidation of oxygenated ferrous cytochrome P450cam and is abolished by reagents that scavenge free radicals, by superoxide dismutase and singlet oxygen quenchers.
Abstract
Chemiluminescence occurs on autoxidation of oxygenated ferrous cytochrome P450cam and is abolished by reagents that scavenge free radicals, by superoxide dismutase and singlet oxygen quenchers. We attribute the chemiluminescence to the decay of an excited singlet oxygen which arises from a superoxide anion radical precursor.
Keywords
ChemistryComputer SciencePharmacology, Toxicology and Pharmaceutics
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