Engraftment and Development of Human T and B Cells in Mice After Bone Marrow Transplantation
SciencePublished 19 April 1991
Ido Lubin, Y Faktorowich, Tsvee Lapidot, Yehudit Gan, Zelig Eshhar, Ephraim Gazit
Citations96
SJR quartileQ1
SJR score10.42
SNIP6.62
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TL;DR
A model for human lymphocyte ontogeny has been developed in a normal mouse and a human antibody response to dinitrophenol could be generated after primary and secondary immunization.
Abstract
A model for human lymphocyte ontogeny has been developed in a normal mouse. Human bone marrow, depleted of mature T and B lymphocytes, and bone marrow from mice with severe combined immunodeficiency were transplanted into lethally irradiated BALB/c mice. Human B and T cells were first detected 2 to 4 months after transplantation and persisted for at least 6 months. Most human thymocytes (30 to 50 percent of total thymocytes) were CD3+CD4+CD8+. Human immunoglobulin was detected in some chimeras, and a human antibody response to dinitrophenol could be generated after primary and secondary immunization.
Keywords
Immunology and MicrobiologyBiochemistry, Genetics and Molecular Biology
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