Antithrombotic Therapy To Prevent Stroke in Patients with Atrial Fibrillation
Annals of Internal MedicinePublished 5 October 1999
Robert G. Hart, Oscar Benavente, Ruth McBride, Lesly A. Pearce
Citations1,628
SJR quartileQ1
SJR score3.38
SNIP3.27
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TL;DR
A meta-analysis of all currently available trials to further characterize the comparative efficacy and safety of antithrombotic therapy for the prevention of stroke in patients with atrial fibrillation is presented.
Abstract
Adjusted-dose warfarin and aspirin reduce stroke in patients with atrial fibrillation, and warfarin is substantially more efficacious than aspirin. The benefit of antithrombotic therapy was not offset by the occurrence of major hemorrhage among participants in randomized trials. Judicious use of antithrombotic therapy, tailored according to the inherent risk for stroke, importantly reduces stroke in patients with atrial fibrillation.
Keywords
Medicine
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