Supplementation with selenium and human immune cell functions
Biological Trace Element ResearchPublished 1 April 1994
Martin Roy, L. Kiremidjian-Schumacher, H. I. Wishe, M. W. Cohen, G. Stotzky
Citations162
SJR quartileQ1
SJR score0.81
SNIP1.11
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TL;DR
It is shown that dietary supplementation of Se-replete humans with 200 μg/d of sodium selenite for 8 wk, or in vitro supplementation with 1×10−7M Se (as sodium Se) result in a significant augmentation of the ability of peripheral blood lymphocytes to respond to stimulation with 1 μg/mL of phytohemagglutinin or alloantigen and to express high affinity Il2-R on their surface.
Abstract
Selenium (Se) is an essential nutritional factor that was shown by us to alter the expression of the high affinity interleukin 2 receptor (Il2-R) and its subunits, cell proliferation, and clonal expansion of cytotoxic T-lymphocytes in mice. This study shows that dietary supplementation of Se-replete humans with 200 micrograms/d of sodium selenite for 8 wk, or in vitro supplementation with 1 x 10(-7) M Se (as sodium selenite), result in a significant augmentation of the ability of peripheral blood lymphocytes to respond to stimulation with 1 microgram/mL of phytohemagglutinin or alloantigen (mixed lymphocyte reaction) and to express high affinity Il2-R on their surface. There was a clear correlation between supplementation with Se and enhanced 3H-thymidine incorporation into nuclear DNA, preceded by enhanced expression of high affinity Il2-R. Supplementation with Se can apparently modulate T-lymphocyte mediated immune responses in humans that depend on signals generated by the interaction of interleukin 2 with Il2-R.
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