Oral Clonidine in Postmenopausal Patients with Breast Cancer Experiencing Tamoxifen-Induced Hot Flashes: A University of Rochester Cancer Center Community Clinical Oncology Program Study
Annals of Internal MedicinePublished 16 May 2000
Kishan J. Pandya, Richard F. Raubertas, Patrick J. Flynn, Harry E. Hynes, Richard J. Rosenbluth, Jeffrey J. Kirshner
Citations309
SJR quartileQ1
SJR score3.38
SNIP3.27
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
A larger randomized, controlled trial was performed that studied the effect of clonidine on hot flashes in women receiving tamoxifen for breast cancer and found its effectiveness in controlling hot flashes caused by natural or surgical menopause.
Abstract
Oral clonidine, 0.1 mg/d, is effective against tamoxifen-induced hot flashes in postmenopausal women with breast cancer.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
New England Journal of MedicineA Randomized Clinical Trial Evaluating Tamoxifen in the Treatment of Patients with Node-Negative Breast Cancer Who Have Estrogen-Receptor–Positive Tumors
1,471 Citations1989B. Fisher, Joe Costantino +19 more
Tamoxifen significantly reduced the rate of treatment failure at local and distant sites, tumors in the opposite breast, and the incidence of tumor recurrence after lumpectomy and breast irradiation and was attained with a low incidence of clinically appreciable toxic effects.
New England Journal of MedicineMegestrol Acetate for the Prevention of Hot Flashes
505 Citations1994Charles L. Loprinzi, John C. Michalak +11 more
Journal of Epidemiology & Community HealthThe menopausal syndrome
435 Citations1974Sonja M. McKinlay, Margot Jefferys
Results of a postal questionnaire survey of 638 women aged 45 to 54, living in the London area in 1964-65, indicate that hot flushes and night sweats are clearly associated with the onset of a natural menopause and that they occur in the majority of women.
Journal of Clinical OncologyProspective evaluation of vitamin E for hot flashes in breast cancer survivors.
406 Citations1998Debra L. Barton, Charles L. Loprinzi +9 more
Although this trial was able to show a statistically significant hot flash reduction with vitamin E compared to a placebo, the clinical magnitude of this reduction was marginal and patients did not prefer vitamin E over the placebo.
Journal of Clinical OncologyTransdermal clonidine for ameliorating tamoxifen-induced hot flashes.
294 Citations1994Richard M. Goldberg, Charles L. Loprinzi +8 more
Clonidine did reduce hot-flash frequency to a degree that was statistically impressive, but clinically moderate, but better means are needed to alleviate hot flashes among patients in whom estrogen therapy is contraindicated.
BMJMenopausal Flushing: Double-blind Trial of a Non-hormonal Medication
222 Citations1974J. R. Clayden, Jonathan Bell +1 more
The relatively mild side effects and the absence of potentially harmful oestrogenic effects suggest that clonidine in the dose range 25 to 75 μg twice daily is a useful addition or alternative to the existing therapy for this common symptom of the menopause.
PubMedEffect of clonidine on hot flashes in postmenopausal women.
142 Citations1982Larry R. Laufer, Y Erlik +2 more
It was concluded that clonidine does reduce the frequency of postmenopausal flashes, and at the maximum dosage the mean rate of hot flash occurrence decreased 46%.
PubMedUse of medroxyprogesterone acetate to prevent menopausal symptoms.
125 Citations1975Bullock Jl, Massey Fm +1 more
DMPA can be an effective alternate to estrogen therapy in selected menopausal patients and was determined by the patients' estimates of the frequency and severity of their hot flashes.
American Journal of Obstetrics and GynecologyObjective evidence that placebo and oral medroxyprogesterone acetate therapy diminish menopausal vasomotor flushes
71 Citations1981Bruce H. Albrecht, Isaac Schiff +2 more
MPA and possibly also placebo were found to reduce not only the subjectively noted VMF but also the frequency of TEs recorded and the frequency and amplitude of LH pulses.
PubMedClonidine (Dixarit) for menopausal flushing.
66 Citations1980R. F. Edington, J. P. Chagnon +1 more
Clonidine is a symptomatic medication that makes flushing more tolerable and should reduce the number of patients who would otherwise be exposed to the risks of estrogens.
MaturitasEffect of megestrol acetate on flushing and bone metabolism in post-menopausal women
47 Citations1981Y Erlik, David R. Meldrum +2 more
It is concluded that progestin therapy may provide an alternative mode of treatment for post-menopausal hot flushes and bone metabolism and definitive demonstration of an effect on post- menopausal bone resorption will require a long-term study of bone density.
The Medical Journal of AustraliaA double‐blind trial with clonidine and a placebo to treat hot flushes
44 Citations1986Barry G. Wren, L. B. Brown
A double‐blind crossover study that compared clonidine and a placebo, which were administered to 19 postmenopausal women who were suffering from hot flushing, failed to demonstrate any statistical reduction in the number of hot flushes.
Journal of Behavioral MedicineThe menopausal hot flush: Symptom reports and concomitant physiological changes
37 Citations1990Leora C. Swartzman, Robert Edelberg +1 more
The Physiological Flush Profile (PFP) consists of peripheral vasodilation plus an increase in skin conductance (sternal and/or palmar) both of a specified magnitude, and was shown to be both a specific and a sensitive measure of hot flushes.
PubMedClinical trials in psychosocial medicine: methodologic and statistical considerations. Part III. Assessing measurement techniques in psychosocial oncology.
13 Citations1980Morrow Gr
Following a discussion of alternative statistical approaches to analyzing a multitrait-multimethod matrix for construct validity, the potential applicability of this approach to clinical oncology is presented through a hypothetical study on quantifying tumor types.
