Plerocercoid growth factor: a Homologue of human growth hormone
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TL;DR
The similarities between the two hormones are discussed, including crossreactivity with strictly specific anti-hGH monoclonal antibodies, which underlie the hypothesis that S. mansonoides has obtained and expresses a human gene for GH.
Abstract
Plerocercoids of the tapeworm, Spirometra mansonoides, produce a factor with characteristics similar to those of mammalian growth hormone (GH). Plerocercoid growth factor (PGF) stimulates growth and mimics other actions of GH but does not possess the anti-insulin/diabetogenic activities intrinsic to mammalian growth hormones. Duplication of activities unique to human GH, chemical and physical similarities, plus crossreactivity with strictly specific anti-hGH monoclonal antibodies, underlie the hypothesis that S. mansonoides has obtained and expresses a human gene for GH. In this article, Kirk Phares discusses the similarities between the two hormones.