Hypothalamic-immune interactions. I. The acute effect of anterior hypothalamic lesions on the immune response
Brain ResearchPublished 1 August 1980
Richard Cross, William R. Markesbery, William H. Brooks, Thomas L. Roszman
Citations150
SJR quartileQ2
SJR score0.85
SNIP0.72
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TL;DR
Rats with electrolytic anterior hypothalamic lesions show changes in lymphoid tissue cellularity and a decrease in the response to concanavalin A, indicating the presence of a neuroendocrine pathway that is capable of modulating immune function.
Abstract
Rats with electrolytic anterior hypothalamic lesions show changes in lymphoid tissue cellularity and a decrease in the response to concanavalin A (Con A). This effect manifests itself maximally 4 days after lesioning, with a return to normal by day 14. The changes are not mediated through the release of corticosteroids. These data indicate the presence of a neuroendocrine pathway that is capable of modulating immune function.
Keywords
PsychologyNeuroscience
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