Anti-Suppressor Cell Effects of Lithium in vitro and in vivo
Advances in experimental medicine and biologyPublished 1 January 1980
Hans‐Michael Dosch, David S. Matheson, Ruud K. B. Schuurman, Erwin W. Gelfand
Citations14
SJR quartileQ3
SJR score0.37
SNIP0.20
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Studies of cellular immunity have recently begun to unravel a highly complex network of regulatory events in which a particular effector function is shown to represent the net result of multiple cell interactions which are modulated by antigenic experience, genetic restrictions, polyclonal effects, and, probably, nutritional and hormonal factors.
Abstract
Studies of cellular immunity nave recently begun to unravel a highly complex network of regulatory events in which a particular effector function is shown to represent the net result of multiple cell interactions which are modulated by antigenic experience, genetic restrictions, polyclonal effects, and, probably, nutritional and hormonal factors. Because of its complexity and ability to accomodate external and internal stimuli in an adaptive learning fashion, the immune network has been compared to the central nervous system (Jerne, 1974).
Keywords
ChemistryBiochemistry, Genetics and Molecular Biology
ScienceLithium: a Modulator of Cyclic AMP-Dependent Events in Lymphocytes?
135 Citations1979Erwin W. Gelfand, Hans‐Michael Dosch +2 more
A role for lithium in the modulation of cyclic AMP-dependent events in lymphocytes is suggested and its potential role as an inhibitor of suppressor cell activity warrants further attention.
NatureInduction and separation of antigen-dependent T helper and T suppressor cells in man
133 Citations1978A Shore, Hans‐Michael Dosch +1 more
It is reported here that primed cell preparations contain antigen-specific suppressor cells which interfere with the induction of PFC in autologous target PFC cultures and could be isolated in the theophylline-sensitive lymphocyte fraction.
PubMedTheophylline modulation of E-rosette formation: an indicator of T-cell maturation.
123 Citations1978Sukanya Limatibul, A Shore +2 more
Investigation of the effect of theophylline on E-rosette formation using cells from normal individuals, and patients with immunodeficiency or acute lymphoblastic leukaemia, and the influence of the drug on distinct T-lymphocyte subpopulations found it to be effective at a distinct stage of precursor T-cell differentiation.
Proceedings of the National Academy of SciencesSelective toxicity of purine deoxynucleosides for human lymphocyte growth and function
106 Citations1979Erwin W. Gelfand, Jacob J. Lee +1 more
Some initial understanding is provided for the selective loss of specific lymphocyte functions in individuals with inborn errors of purine metabolism in the context of inherited deficiencies of these enzymes.
The Journal of ImmunologyGeneration of Human Plaque-Forming Cells in Culture: Tissue Distribution, Antigenic and Cellular Requirements
100 Citations1977Hans‐Michael Dosch, Erwin W. Gelfand
A tentative model of cellular interaction has been postulated, suggesting a major role for antigen concentration in the modulation of the response via reactive T lymphocytes.
NatureBiphasic effect of cyclic AMP on an immune response
46 Citations1974Hung‐Sia Teh, Verner Paetkau
The same agents which might enhance an AFC response if present during the increased cyclic AMP phase, could inhibit the response ifPresent during the subsequent phase of declining intracellular cyclicAMP.
PubMedFunctional differentiation of B lymphocytes in congenital agammaglobulinemia. I. Generation of hemolytic plaque-forming cells.
41 Citations1977Hans‐Michael Dosch, Maire E. Percy +1 more
Findings indicate the presence of B lymphocyte precursors in the majority of patients with cAgamma investigated, and specifically a specific hemolytic plaque-forming cell response in vitro to sheep red blood cells and ovalbumin.
Advances in experimental medicine and biologyCharacterization of Lithium Effects on Two Aspects of T-Cell Function
38 Citations1980Erwin W. Gelfand, R. Cheung +2 more
These studies indicate the validity of using lithium for assessing the role of the lymphocyte adenylate cyclase-cyclic AMP system in the generation and expression of regulatory signals leading to modulation of the immune system.
PubMedFunctional differentiation of B lymphocytes in agammaglobulinemia. III. Characterization of spontaneous suppressor cell activity.
35 Citations1978Hans‐Michael Dosch, Erwin W. Gelfand
Cells mediating SSA may play a role in preventing the normal transition of pre-B cells to B cells in patients with agammaglobulinemia without B lymphocytes.
The Journal of ImmunologyRegulation of the in Vitro Early Anamnestic Antibody Response by Exogenous Cholera Enterotoxin and Cyclic AMP
34 Citations1975Richard G. Cook, Abram B. Stavitsky +1 more
Both IgM and IgG antibody synthesis were regulated by exogenous cholera toxin and dibutyryl cyclic AMP, and a number of possible cellular mechanisms of regulation of the antibody response through the cycled AMP pathway were discussed.
The Journal of ImmunologyFunctional Differentiation of B Lymphocytes in Congenital Agammaglobulinemia
29 Citations1977Hans‐Michael Dosch, Maire E. Percy +1 more
Pediatric Clinics of North AmericaImmune Deficiency: Evaluation, Diagnosis, and Therapy
27 Citations1974Erwin W. Gelfand, W. Douglas Biggar +1 more
The striking advances made have resulted in the dramatic cure of combined immunodeficiency disease by bone marrow transplantation as well as more effective prevention of recurrent infections in patients with antibody-deficiency syndromes through the judicious use of gammaglobulin.
The Journal of ImmunologyFunctional Differentiation of B Lymphocytes in Agammaglobulinemia
24 Citations1978Hans‐Michael Dosch, Erwin W. Gelfand
Cells mediating SSA may play a role in preventing the normal transition of pre-B cells to B cells in patients with agammaglobulinemia without B lymphocytes.
The Journal of ImmunologyIdentification of Ia on a subpopulation of human T lymphocytes that stimulate in a mixed lymphocyte reaction.
16 Citations1980Ruud K. B. Schuurman, Erwin W. Gelfand +3 more
The presence of Ia determinants on the theophylline-sensitive T cells indicates the expression of major histocompatibility complex-related regulatory gene products on a specific human T lymphocyte subpopulation.
European Journal of ImmunologyRegulation of the specific plaque‐forming cell responsein man: Restraint of B cell responsiveness
14 Citations1979Hans‐Michael Dosch, A Shore +1 more
In mixedlymphocyte populations, antigen concentration is a valuable probe for studies of the balance of discrete T cell subpopulations but not for absolute B cell responsiveness.
PubMedFunctional differentiation of B lymphocytes in congenital agammaglobulinemia. II. Immunochemical analysis of the in vitro primary immune response.
14 Citations1977Maire E. Percy, Hans‐Michael Dosch +1 more