The effects of lateral hypothalamic lesions on food intake and instrumental alimentary reflex in dogs.

PubMedPublished 1 January 1970

E Rozkowska, E Fonberg

Citations16

TL;DR

The present paper is concerned with the effect of lateral hypothalamic lesions on food intake and instrumental alimentary reactions as well as on the general activity and emotional behavior of dogs.

Abstract

Since Anand and Brobeck (1951) localized the feeding center in the lateral hypothalamus, the role of hypothalamic structures in alimentary mechanisms has been studied by many investigators (Teitelbaum and Stellar 1954, Miller 1957, Wyrwicka 1957, Chereshniev 1960, Morgane 1961a, Teitelbaum and Epstein 1962, Balinska 1963, Balinska and Brutkowski 1967, Wyrwicka 1967ab and others). Most of the results concerning the lateral hypothalamic syndrome were obtained on rats, rabbits, cats, goats and monkeys, whereas few data were obtained on dogs. We purposefully chose the dogs as experimental subjects because they are very well known from the point of view of various conditioned reflex #activities. In addition, their social relations with humans and lively emotional expression give one the opportunity for detecting even small changes in emotional behavior and motivation, caused by the operation, and make possible the undertaking of detailed studies on the various aspects of hypothalamic lesions. The present paper is concerned with the effect of lateral hypothalamic lesions on food intake and instrumental alimentary reactions as well as on the general activity and emotional behavior of dogs.

Keywords

PsychologyMedicineNeuroscience

Archives of Neurology And PsychiatryTHE VOMITING CENTER

140 Citations1950Shuji Wang

In the past few decades it has been the vogue for physiologists to label as a center any part of the animal organism which fits into the total integrated response.

Physiology & BehaviorAphagia and adipsia following unilateral and bilaterally asymmetrical lesions in rats

128 Citations1967Richard M. Gold

Unilateral direct current lesions centered in the internal capsule produced as long as 18 days of aphagia relative to dry meal and as longAs 33 days of adipsia and these anatomical correlates were also demonstrated using the conventional bilaterally symmetrical lesions.

American Journal of Physiology-Legacy ContentDecreased spontaneous locomotor activity in the rat induced by hypothalamic lesions

82 Citations1962W.E. Gladfelter, John R. Brobeck

Activity was decreased to a much lower level after lateral lesions than after medial lesions, and hypoactivity seemed to occur independently of other signs of hypothalamic impairment.

Acta Physiologica ScandinavicaThe Effect of Hypothalamic Lesions on the Water Intake of the Dog.

78 Citations1955Basileiades OCh, Samuel M. McCann

The Journal of PhysiologyThe nature of the suppression of food intake by lateral hypothalamic lesions in rats

72 Citations1963P Baillie, S. D. Morrison

The experiments described here used both approaches by applying the general technique of operant conditioning to feeding behaviour, and the suppression of food intake consequent on destruction of the areas could be a true aphagia rather than a type of anorexia.

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Physiology & BehaviorEffects of small dorsomedial amygdala lesions on food intake and acquisition of instrumental alimentary reactions in dogs

46 Citations1969Elżbieta Fonberg

Bilateral small stereotaxic lesions limited to dorsomedial part of the amygdaloid complex resulted in aphagia with subsequent longlasting hypophagia, adipsia, vomiting and impairment of the acquisition of instrumental alimentary reactions in dogs.