Distinguishing Benign from Malignant Pulmonary Nodules with Helical Chest CT in Children with Malignant Solid Tumors
RadiologyPublished 1 May 2006Open access
M. Beth McCarville, Henrique Manoel Lederman, Victor M. Santana, Najat C. Daw, Stephen J. Shochat, Chin-Shang Li
Citations133
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TL;DR
The frequency of benign nodules and the inconsistency of predictions based on CT features suggest the need for better predictors of pulmonary nodules being malignant or benign, so as to reduce unnecessary thoracotomy in pediatric patients with solid malignancy.
Abstract
The frequency of benign nodules and the inconsistency of predictions based on CT features suggest the need for better predictors of pulmonary nodules being malignant or benign, so as to reduce unnecessary thoracotomy in pediatric patients with solid malignancy. .
Keywords
Medicine
RadiologySpiral volumetric CT with single-breath-hold technique, continuous transport, and continuous scanner rotation.
1,032 Citations1990Willi A. Kalender, W. Seissler +2 more
The authors modified the table feed mechanism of a continuously rotating CT scanner to allow patient transport at low, but accurately controlled, speeds during continuous 1-second scanning to study continuous computed tomographic scanning of organ volumes during a single breath hold.
New England Journal of MedicineThe Solitary Pulmonary Nodule
681 Citations2003David E. Ost, Alan M. Fein +1 more
A 60-year-old man undergoes chest radiography during an evaluation for pneumonia, and a 1.5-cm nodule is discovered, and he is a heavy smoker but has no history of lung disease.
RadiologyCT of the pulmonary nodule: a cooperative study.
319 Citations1986Elias A. Zerhouni, Frederick P. Stitik +8 more
It is concluded that thin-section CT aided by a reference phantom in equivocal cases should be an integral part of the diagnostic approach to the pulmonary nodule.
RadiologyPulmonary nodules: detection with thick-section spiral CT versus conventional CT.
251 Citations1993Martine Rémy‐Jardin, Jacques Rémy +2 more
Spiral volumetric computed tomography with single breath-hold technique was compared with conventional sequential CT in 39 patients, finding mean number of nodules per patient was significantly higher with spiral versus conventional CT.
RadiologyMalignant versus Benign Nodules at CT Screening for Lung Cancer: Comparison of Thin-Section CT Findings
249 Citations2004Feng Li, Shusuke Sone +3 more
Recognition of certain characteristics at thin-section CT can be helpful in differentiating small malignant nodules from benign nodules.
CHEST JournalManaging the Small Pulmonary Nodule Discovered by CT
203 Citations2004Daniel M. Libby, James P. Smith +4 more
The two diagnostic techniques most useful in evaluating the CT-detected, small, noncalcified pulmonary nodule are short-term observation of nodule growth by CT and CT-guided FNA.
RadiologyDifferentiation of Benign and Malignant Pulmonary Nodules by Growth Rate
185 Citations1962M. Herbert Nathan, V. Peter Collins +1 more
The presence of any calcification in a pulmonary lesion makes malignancy extremely unlikely, although it is recognized that minute central calcification can on rare occasions be found in malignant lesions.
RadiologyLung: spiral volumetric CT with single-breath-hold technique.
155 Citations1990Peter Vock, M Souček +2 more
The authors conclude that spiral volumetric CT, by completely surveying a subvolume of the lung, is an attractive new application of CT.
Clinics in Chest MedicineEVALUATION AND MANAGEMENT OF SOLITARY AND MULTIPLE PULMONARY NODULES
143 Citations1993Glen A. Lillington, Cynthia I. Caskey
Solitary pulmonary nodules are malignant in 50% of cases and the 5-year cure rate after resection of a malignant nodule averages 50% and is even higher if the nodule is small.
RadiologyPulmonary Nodules Resected at Video-assisted Thoracoscopic Surgery: Etiology in 426 Patients
142 Citations1999Michelle S. Ginsberg, Simone Kahn Griff +4 more
A single pulmonary nodule resected at VATS was more likely to be malignant in patients with known cancer than in patients without known cancer.
RadiologySmall pulmonary lesions detected at CT: clinical importance.
115 Citations1997Reginald F. Munden, R. D. Pugatch +3 more
Early biopsy with an acceptable technique for diagnosis of small pulmonary lesions present on CT scans can substantially alter treatment and a considerable number of the malignant lesions were primary bronchogenic carcinoma.
PubMedManaging solitary pulmonary nodules. The choice of strategy is a "close call".
101 Citations1986Steven R. Cummings, Glen A. Lillington +1 more
Patients should give greater weight to considerations besides life expectancy when choosing between management strategies, and should encourage patients to actively participate in the decisions about how to manage their solitary pulmonary nodules.
International Journal of Radiation Oncology*Biology*PhysicsSignificance and management of computed tomography detected pulmonary nodules: a report from the National Wilms Tumor Study Group
89 Citations1999Jay A. Meisel, Katherine A. Guthrie +3 more
The current data raise the possibility that children with Wilms tumor and CT-only pulmonary nodules who receive whole lung irradiation have fewer pulmonary relapses, but a greater number of deaths due to treatment toxicity.
Journal of Clinical OncologyRole of Chest Computed Tomography at Diagnosis in the Management of Wilms’ Tumor: A Study by the United Kingdom Children’s Cancer Study Group
86 Citations2002Cátherine M. Owens, Paul Veys +4 more
CT seemed to identify a subgroup of stage I patients who were at increased risk of pulmonary relapse who had received only single-agent chemotherapy, and a prospective randomized trial is needed to clarify whether these children would benefit from combination chemotherapy.
Clinical RadiologyAn analysis of 155 solitary lung lesions illustrating the differential diagnosis of mixed tumours of the lung
81 Citations1965Eric M. Bateson
It has been shown that mixed tumours form a significant proportion of most series of solitary lung lesions, and it is possible to differentiate, mainly by their radiological appearances, about one third of mixed tumour types from the other types of solitary Lung lesions.
Journal of Pediatric SurgerySurgical management and outcome of osteosarcoma patients with unilateral pulmonary metastases
61 Citations2004Wendy Su, Joseph H. Chewning +6 more
Staged bilateral thoracotomies should be considered in osteosarcoma patients presenting with unilateral pulmonary disease on imaging studies within 2 years of diagnosis, as there is a high rate of contralateral involvement in patients with unilateral nodules diagnosed by CT scan.
American Journal of RoentgenologyAccuracy of Interpretation of CT Scans: Comparing PACS Monitor Displays and Hard-Copy Images
57 Citations2002Bruce I. Reiner, Eliot L. Siegel +1 more
Soft-copy interpretation using computer workstations was found to produce statistically significant improvement in combined measurements of sensitivity, specificity, and overall accuracy for chest, brain, and chest-abdominal CT scans compared with film interpretation.
CancerPrognostic factors and imaging patterns of recurrent pulmonary nodules after thoracotomy in children with osteosarcoma
50 Citations2001M. Beth McCarville, Sue C. Kaste +4 more
In children with osteosarcoma who have undergone thoracotomy, it often is difficult to distinguish metastatic from benign recurrent pulmonary nodules, so any computed tomography imaging pattern of recurrent pulmonary metastases in this patient population is sought.
Current Opinion in Pulmonary MedicineManagement strategies for the solitary pulmonary nodule
49 Citations2004David E. Ost, Alan M. Fein
In patients with average surgical risk, positron emission tomography (PET) scan is warranted when there is discordance between pretest probability of cancer and the appearance of the nodule on CT scan, and when the CT appears benign, PET scan will be cost effective.
American Journal of Roentgenology“Ditzels” on Chest CT
49 Citations2001Reginald F. Munden, Kenneth R. Hess
Clinical RadiologyPaediatric pulmonary nodules: a comparison of computed tomography, thoracotomy findings and histology
41 Citations1988Patricia L. Robertson, David W. Boldt +1 more
Computed tomography studies of the lungs prior to thoracotomy in 15 children with presumed pulmonary metastases were compared retrospectively with surgical and pathological findings and it was found that nodules that increased in size on serial CT contained viable tumour.
American Journal of RoentgenologyLiver and Bone Window Settings for Soft-Copy Interpretation of Chest and Abdominal CT
37 Citations2000Stephen M. Pomerantz, Charles S. White +5 more
The use of multiple window and level settings during soft-copy interpretation resulted in improved lesion detectability and characterization with greater diagnostic efficacy.
Pediatric RadiologyChest radiography versus chest CT in the evaluation for pulmonary metastases in patients with Wilms' tumor: a retrospective review
27 Citations2000Sandra L. Wootton‐Gorges, Edythe A. Albano +4 more
CXR alone appears adequate for the diagnosis or exclusion of pulmonary metastases in patients with Wilms' tumor, and concur in 79/81 (98 %).
Cleveland Clinic Journal of MedicineManaging solitary pulmonary nodules
20 Citations1998P. Jain, Salim A. Kathawalla +1 more
A solitary pulmonary nodule on a chest radiograph represents a major diagnostic dilemma and the goals of management are to resect malignant tumors without delay and to avoid unnecessary thoracotomy if the nodule is benign.
Clinical ImagingSolitary pulmonary nodules
18 Citations2004Shingo Iwano, N Makino +5 more
HRCT could be used to differentiate more accurately the malignant nodules from the benign ones using 1-mm-thick sections than 3- or 5- mm-Thick sections.
Seminars in Thoracic and Cardiovascular SurgeryManagement of the solitary pulmonary nodule: Directed resection
12 Citations2002Joel D. Cooper
By combining appropriate diagnostic studies, and close personal attention, unnecessary excision of benign nodules can be kept to a minimum, patient anxiety allayed and excison of cancers undertaken with appropriate staging and without compromise of outcome.
