Haloperidol impairs classically conditioned nictitating membrane responses and conditioning-related cerebellar interpositus nucleus activity in rabbits
Pharmacology Biochemistry and BehaviorPublished 1 August 1990
Lonnie L. Sears, Joseph E. Steinmetz
Citations29
SJR quartileQ1
SJR score0.95
SNIP0.81
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
HAL appeared to disrupt CRs and interpositus activity by increasing the intensity threshold of the tone CS for eliciting conditioned responses and reducing the number of conditioned responses when a 75 and 85 dB tone conditioned stimulus was presented.
Abstract
Rabbits, chronically implanted with recording electrodes in the cerebellar interpositus nucleus and following acquisition of a classically conditioned eyelid response, were injected with haloperidol (HAL, 250 micrograms/kg). HAL significantly reduced the number of conditioned responses when a 75 and 85 dB tone conditioned stimulus (CS) was presented but not when a 95 dB tone CS was used. There was a corresponding decrease in interpositus activity at the 75 and 85 dB CS intensities but not at the 95 dB intensity. HAL appeared to disrupt CRs and interpositus activity by increasing the intensity threshold of the tone CS for eliciting conditioned responses. Possible mechanisms for the effect of HAL on neural circuitry involved in classical eyelid conditioning are discussed.
Keywords
Neuroscience
Behavioral NeuroscienceHippocampus and trace conditioning of the rabbit's classically conditioned nictitating membrane response.
677 Citations1986Paul R. Solomon, Ellen R. Vander Schaaf +2 more
The data show that early in training, and well before any CRs occurred, there was a substantial increase in neuronal activity in the hippocampus that began during the CS and persisted through the trace interval and formed a model of the amplitude-time course of the behavioral CR.
Experimental Brain ResearchClassical conditioning of the nictitating membrane response of the rabbit
545 Citations1985C. H. Yeo, M. J. Hardiman +1 more
The classically conditioned nictitating membrane response of the rabbit, a simple form of associative motor learning, is crucially dependent upon the cerebellum and Lesions of the anterior interpositus nucleus abolished NMR conditioning to light and white noise stimuli on the side of the lesion without affecting unconditional responses.
Brain ResearchNeuronal plasticity in the limbic system during classical conditioning of the rabbit nictitating membrane response. I. The hippocampus
524 Citations1978Theodore W. Berger, Richard F. Thompson
Hippocampal unit responses were recorded throughout classical conditioning of the rabbit nictitating membrane response to a tone conditioned stimulus using a corneal air-puff unconditioned stimulus, revealing a rapidly developing increase in cell discharges within the first block of paired trials.
Journal of NeuroscienceNeuronal responses of the rabbit cerebellum during acquisition and performance of a classically conditioned nictitating membrane-eyelid response
406 Citations1984David A. McCormick, RF Thompson
It is shown that lesions of the regions of cerebellar cortex projecting to the dentate-interpositus nuclei do not permanently abolish the conditioned response, although the amplitude- time course of the learned response could be affected.
Journal of NeuroscienceAutoradiographic localization of sigma receptor binding sites in guinea pig and rat central nervous system with (+)3H-3-(3-hydroxyphenyl)-N-(1- propyl)piperidine
393 Citations1986AL Gundlach, BL Largent +1 more
There is a notable similarity between the distribution of (+)3H-3-PPP sites and high-affinity binding sites for psychotomimetic opioids, such as the benzomorphan (+)SKF 10,047.
ScienceNictitating Membrane: Classical Conditioning and Extinction in the Albino Rabbit
385 Citations1962I. Gormezano, Neil Schneiderman +2 more
The distribution of response latencies and the percentage performance curve of a classical conditioning group, by comparison with a control group, indicated that the extension of the nictitating membrane elicited by a puff of air to the cornea was successfully conditioned to a previously neutral stimulus.
Journal of Pharmacology and Experimental TherapeuticsPharmacological and autoradiographic discrimination of sigma and phencyclidine receptor binding sites in brain with (+)-[3H]SKF 10,047, (+)-[3H]-3-[3-hydroxyphenyl]-N-(1-propyl)piperidine and [3H]-1-[1-(2-thienyl)cyclohexyl]piperidine.
348 Citations1986B L Largent, Andrew L. Gundlach +1 more
Pharmacological and autoradiographic analyses reveal that (+)-[3H]SKF 10,047 labels two sites in brain: a high affinity site resembling the sigma receptor and a second site, labeled with lower affinity, similar to the phencyclidine (PCP) receptor.
Behavioural Brain ResearchHippocampectomy selectively disrupts discrimination reversal conditioning of the rabbit nictitating membrane response
338 Citations1983Theodore W. Berger, William B. Orr
Results showed that hippocampectomized animals learned the initial two-tone discrimination at rates equivalent to operated control animals and animals with neocortical lesions, but during reversal conditioning, animals with hippocampal lesions were severely impaired relative to both other groups.
Proceedings of the National Academy of SciencesInitial localization of the memory trace for a basic form of learning.
332 Citations1982David A. McCormick, Gregory A. Clark +2 more
It is suggested that at least part of the essential neuronal plasticity that codes the learned response may be localized to the cerebellum.
ScienceAltered Activity in the Hippocampus Is More Detrimental to Classical Conditioning Than Removing the Structure
329 Citations1983Paul R. Solomon, Scott D. Solomon +2 more
Experimental Brain ResearchCerebellar Purkinje cell activity related to the classically conditioned nictitating membrane response
300 Citations1986Neil E. Berthier, John W. Moore
In demonstrating CR-related activity in Cerebellar PCs, this study supports theories of cerebellar learning such as those of Marr and Albus.
Brain ResearchRetention of classically conditioned eyelid responses following acute decerebration
233 Citations1987Michael D. Mauk, Richard F. Thompson
Data indicate that the conditioned response pathway, and sites of plasticity, for eyelid conditioning are spared by decerebration and are contained within the brainstem and cerebellum.
Proceedings of the National Academy of SciencesInitial localization of the acoustic conditioned stimulus projection system to the cerebellum essential for classical eyelid conditioning.
184 Citations1987J E Steinmetz, C G Logan +4 more
Electrophysiological, anatomical, and lesion data suggest that cells within the lateral pontine nuclear region may be essentially involved in projecting information concerning the occurrence of acoustic conditioned stimuli to the cerebellum during classical conditioning.
Behavioral NeuroscienceClassical conditioning of the rabbit eyelid response with a mossy-fiber stimulation CS: I. Pontine nuclei and middle cerebellar peduncle stimulation.
181 Citations1986Joseph E. Steinmetz, Daniel J. Rosen +3 more
The nictitating membrane/eyelid responses of 18 rabbits were classically conditioned using cerebellar mossy-fiber stimulation as a conditioned stimulus (CS) and air puff as an unconditioned stimulus (US).
NeuroscienceAutoradiographic visualization of haloperidol-sensitive sigma receptors in guinea-pig brain
177 Citations1988Stafford McLean, E Weber
The anatomical distribution of the haloperidol-sensitive sigma receptors is distinct from the pattern of phencyclidine receptors and suggests sigma compounds may effect endocrine, emotional and motor behavior.
Journal of Pharmacology and Experimental TherapeuticsSigma receptors in post-mortem human brains.
169 Citations1988Arthur D. Weissman, Tung‐Ping Su +2 more
The pharmacological profile and regional distribution of sigma receptors in human autopsy brains were determined using [3H]-haloperidol as the ligand, in the presence of 50 nM spiperone to block binding to D2 dopamine sites.
NeuroscienceHippocampal signal transmission to the pedunculopontine nucleus and its regulation by dopamine D2 receptors in the nucleus accumbens: An electrophysiological and behavioural study
167 Citations1987CR Yang, Gordon J. Mogenson
Results provide evidence of limbic influences on locomotor activity by way of nucleus accumbens-subpallidal-pedunculopontine nucleus connections which may contribute to adaptive behaviour and suggest D2 receptors regulate locomotor responses initiated by the hippocampal-accumbens pathway.
Brain ResearchIpsilateral cerebellar lesions prevent learning of the classically conditioned nictitating membrane/eyelid response
159 Citations1982Jann S. Lincoln, David A. McCormick +1 more
Unilateral lesions of the cerebellum in the rabbit prior to any training completely prevented learning of the classically conditioned eyelid and nictitating membrane responses of the eye ipsilateral to the lesion.
Behavioral NeuroscienceRetention and acquisition of classical trace conditioned responses by rabbits with hippocampal lesions.
123 Citations1986Richard L. Port, et al
Behavioral NeuroscienceLesions of the retrosplenial cortex produce deficits in reversal learning of the rabbit nictitating membrane response: Implications for potential interactions between hippocampal and cerebellar brain systems.
94 Citations1986Theodore W. Berger, Catherine L. Weikart +2 more
Findings are interpreted within a conceptual framework that characterizes multisynaptic projections from the hippocampus to the retrosplenial cortex, and ultimately to the cerebellum, as responsible for the behavioral expression of learning-related changes in hippocampal pyramidal cell activity.
Physiology & BehaviorConcomitant heart rate and corneoretinal potential conditioning in the rabbit (Oryctolagus Cuniculus): Effects of caudate lesions
72 Citations1978D. A. Powell, Donald Mankowski +1 more
A deficit in a specific learned somatomotor response is demonstrated but no impairment in the autonomic changes which usually accompany Somatomotor conditioning is demonstrated.
Physiology & BehaviorBrachium conjuntivum and rubrobulbar tract: Brain stem projections of red nucleus essential for the conditioned nictitating membrane response
70 Citations1985Marcy E. Rosenfield, A. Dovydaitis +1 more
The conclusion that an essential premotor component of the conditioned NM response is a doubly decussating circuit from the interpositus nucleus of the cerebellum to magnocellular red nucleus, via brachium conjunctivum and its decussation is strongly supported.
Journal of Pharmacology and Experimental TherapeuticsEffects of haloperidol and pimozide on classical conditioning of the rabbit nictitating membrane response.
49 Citations1981J A Harvey, I. Gormezano
It was concluded that haloperidol blocks both the conditioned and unconditioned excitatory properties of a tone and this accounts for its ability to retard the rate of CR acquisition.
Behavior Research Methods, Instruments, & ComputersAn inexpensive interface for the IBM PC/XT and compatibles
46 Citations1989David G. Lavond, Joseph E. Steinmetz
An inexpensive interface designed for IBM PC/XTs or compatibles, potentially useful for controlling behavioral/neural experiments, is presented and descriptions of basic machine language routines for the control of input/output functions, timing, and data acquisition by the interface are provided.
Behavioral NeuroscienceLesions of the substantia nigra retard Pavlovian eye-blink but not heart rate conditioning in the rabbit.
33 Citations1988Kuen-teng Kao, D. A. Powell
Brain ResearchPharmacological analysis of the magnocellular red nucleus during classical conditioning of the rabbit nictitating membrane response
32 Citations1988Deborah A. Haley, Richard F. Thompson +1 more
It is demonstrated that microinfusion of a GABA antagonist into the magnocellular red nucleus can selectively and reversibly reduce or abolish retention of the CR, without altering the unconditioned reflex response.
Brain ResearchReciprocal anatomical connections between anterior thalamus and cingulate—retrosplenial cortex in the rabbit
31 Citations1980Theodore W. Berger, Teresa A. Milner +3 more
Reciprocal anatomical connections between posterior limbic cortex and anterior thalamus in the rabbit were investigated using horseradish peroxidase histochemistry and showed that the cells of origin for corticofugal fibers are contained only within deep cortical layers, while thalamofugal projections terminate only within superficial laminae.
Elsevier eBooksNeural Circuit for Classical Conditioning of the Eyelid Closure Response
21 Citations1989Richard F. Thompson
Lesion and microstimulation data suggest that the essential conditioned stimulus (CS) pathway includes mossy fiber projections to the cerebellum via the pontine nuclei, and sufficiently large lesions of the middle cerebellar peduncle prevent acquisition and immediately abolish retention of the eyelid conditioned response (CR).
Essential Involvement of Mossy Fibers in Projecting the CS to the Cerebellum during Classical Conditioning
15 Citations1988Joseph E. Steinmetz, Christine Logan +1 more
In an attempt to delineate the essential neural circuitry involved in classical eyelid conditioning, the working hypothesis is adopted that neural plasticity associated with acquisition and retention of the classically conditioned response occurs in regions of the cerebellum where CS mossy fibers and US climbing fibers converge.