Bacterial Infection in Chronic Obstructive Pulmonary Disease
American Review of Respiratory DiseasePublished 1 October 1992
Timothy F. Murphy, Sanjay Sethi
Citations584
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Abstract
"Bacterial Infection in Chronic Obstructive Pulmonary Disease." American Review of Respiratory Disease, 146(4), pp. 1067–1083
Keywords
Medicine
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325 Citations1987Timothy F. Murphy, M. A. Apicella
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251 Citations1983Jonathan M. Samet, Ira B. Tager +1 more
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235 Citations1961Gustave A. Laurenzi, Robert T. Potter +1 more
The role of infection in the decline of the bronchitic patient is indicated by the morphologic findings in the Bronchopulmonary tree, by the relative success of antibacterial treatment of the acute illness and by the occasional effectiveness of the prophylactic use of selected antibiotics.
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222 Citations1980Regine Hakenbeck, Martha Tarpay +1 more
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198 Citations1990Daniel M. Musher, M. J. Luchi +3 more
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192 Citations1983Daniel M. Musher, KENNETH R. KUBITSCHEK +2 more
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187 Citations1986David J. Barker, Clive Osmond
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183 Citations1987Benjamin Burrows, Ronald J. Knudson +3 more
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176 Citations1985Robert Wilson, David E. Roberts +1 more
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The American Journal of MedicineInefficacy of pneumococcal vaccine in a high-risk population
174 Citations1987Harriet Forrester, Dennis W. Jahnigen +1 more
Pneumococcal vaccine did not appear to be protective in this high-risk population of patients, and serotype distribution should be different in vaccinated and nonvaccinated bacteremic patients.
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173 Citations1991R. Rossau, Anita Van Landschoot +2 more
DNA-rRNA hybridization results showed that members of the genus Moraxella, members ofthe genus Psychrobacter and their relatives, membersof the genus Acinetobacter, the false neisseriae, and two misnamed Alysiella strains constitute a separate genotypic cluster, and a new family, Moraxellaceae, is proposed to accommodate these organisms.
Annals of Internal MedicineAntibiotic Therapy of Acute Exacerbations of Chronic Bronchitis
167 Citations1982M. Brooke Nicotra, MANUEL RIVERA +1 more
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167 Citations1986Rachel Schneerson, John B. Robbins +8 more
Conjugate-induced antibodies to both the polysaccharide and TT exerted biological activities that have been correlated with immunity and encourage the evaluation of Hib and Pn6A conjugates in human children and infants.
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162 Citations1989I. Riesenfeld-Orn, Stephen D. Wolpe +3 more
The dissociation of the production of IL-1 and TNF during the response of the human monocyte to pneumococcal surface components suggests that, in at least some circumstances, the mechanisms for generation of an inflammatory response to infection may be fundamentally different between gram-positive and gram-negative disease.
Clinical Infectious DiseasesBranhamella catarrhalis Respiratory Infections
161 Citations1987H. Hager, Abraham Verghese +2 more
The typical clinical picture was that of purulent tracheobronchitis; patients with pneumonia were not severely ill and differed from those with bronchitis mainly by the presence of patchy lower-lobe infiltrates on chest roentgenogram.
The Journal of Infectious DiseasesA Subtyping System for Nontypable Haemophilus influenzae Based on Outer-Membrane Proteins
145 Citations1983Timothy F. Murphy, Kathleen C. Dudas +2 more
Eight subtypes were identified based on the differences in molecular weights of the two principal outer-membrane proteins of nontypable Haemophilus influenzae and the lower molecular-weight protein of those two major proteins was heat modifiable.
The Journal of Infectious DiseasesInteraction of Nontypable Haemophilus influenzae with Human Respiratory Mucosa In Vitro
144 Citations1991Robert C. Read, Robert Wilson +6 more
Fimbriation of H. influenzae increased buccal cell adherence but did not facilitate association with normal respiratory epithelium and failed to increase epithelial damage or association with damaged cells.
The Journal of Experimental MedicineMonoclonal antibodies against protease-sensitive pneumococcal antigens can protect mice from fatal infection with Streptococcus pneumoniae.
139 Citations1984Larry S. McDaniel, G Scott +2 more
Monoclonal antibodies raised against surface determinants of Streptococcus pneumoniae by hyperimmunizing X-linked immunodeficient CBA/N mice with the heat-killed rough strain R36A appeared to bind surface polypeptides and binding studies indicated that these two antibodies recognized different epitopes that were expressed on several but not all serotypes of pneumococci.
BMJBronchopulmonary infection due to Branhamella catarrhalis: 11 cases assessed by transtracheal puncture.
138 Citations1978G Ninane, J Joly +1 more
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Archives of Internal MedicineBranhamella catarrhalis as a Lower Respiratory Tract Pathogen in Patients With Chronic Lung Disease
137 Citations1986Brooke Nicotra
In patients with chronic lung disease, the presence of B catarrhalis in sputum can be suspected on the basis of a Gram's stain and may be associated with the development of new pneumonic infiltrates, since these organisms frequently produce beta-lactamase.
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124 Citations1986Timothy F. Murphy, L C Bartos +4 more
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108 Citations1949W. Barry Wood, Mary Ruth Smith
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107 Citations1978R. O. Buscho, D. Saxtan +3 more
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107 Citations1988James M. Musser, J. Simon Kroll +2 more
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106 Citations1985Robert Clancy, K Murree-Allen +3 more
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101 Citations1987Timothy F. Murphy, Joel M. Bernstein +3 more
Analysis of middle ear isolates from four children with recurrent otitis media caused by nontypable H. influenzae indicated that the recurrent episodes were caused by reinfection with different strains rather than by persistence of the same strain.
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101 Citations1981Alexander Tomasz
Some morphological, biochemical, and physiological features of the pneumococcal cell wall and plasma membrane that may have a bearing on the interactions between aneumococcal pathogen and components of an invaded host are summarized.
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101 Citations1985Andrew Chapman, Daniel M. Musher +3 more
It is suggested that most patients with pulmonary infections due to B. catarrhalis develop a convalescent IgG antibody response that mediates serum bactericidal activity by the classic complement pathway.
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100 Citations1986Monica M. Farley, David S. Stephens +5 more
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99 Citations1982Janet Yother, C Forman +2 more
It is found that mice expressing the X-linked immunodeficiency of the CBA/N strain were found to be more susceptible to infection with S. pneumoniae of types 3, 6A, and 19F than were immunologically normal mice.
The Journal of Infectious DiseasesDoes Naturally Acquired IgG Antibody to Cell Wall Polysaccharide Protect Human Subjects against Pneumococcal Infection?
95 Citations1990D. M. Musher, David Watson +1 more
The data suggest that naturally present anti-CWPS IgG does not protect against the evolution of acute pneumococcal infection from colonization to acute purulent bronchitis, fromBronchitis to pneumonia, or from pneumonia to bacteremia.
The Journal of Infectious DiseasesPenicillin Tolerance in Multiply Drug-Resistant Natural Isolates of Streptococcus pneumoniae
95 Citations1985H. H. Liu, Alexander Tomasz
Five of six multiply drug-resistant clinical isolates of Streptococcus pneumoniae from South Africa demonstrated penicillin tolerance, suggesting that the drug-specific tolerance of the South African pneumococcal strains is related to some alteration in the control of autolysin activity.
Journal of Clinical MicrobiologyBiotypes of Haemophilus encountered in clinical laboratories
93 Citations1979Thomas R. Oberhofer, A E Back
The biochemical characteristics of 464 strains of Haemophilus influenzae and 83 strains of H. parainfluenzae isolated over an 18-month period are described and it is found that multiple isolates recovered from the same patient were almost always of the same biotype.
British Journal of Diseases of the ChestAntibiotic regimens in moderately ill patients with purulent exacerbations of chronic bronchitis
93 Citations1972A. Pines, H. Raafat +3 more
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PubMedBacterial flora of the respiratory tract in chronic bronchitis: comparison of transtracheal, fiberbronchoscopic, and oropharyngeal sampling methods.
92 Citations1977Helmut Haas, James F. Morris +3 more
The bacterial flora of the respiratory tract was studied in 24 male patients with chronic bronchitis, 52 years of age and older and found to be highly reliable in ascertaining the presence of Haemophilus influenzae and Streptococcus pneumoniae.
Infection and ImmunityQuantitative relationship between anticapsular antibody measured by enzyme-linked immunosorbent assay or radioimmunoassay and protection of mice against challenge with Streptococcus pneumoniae serotype 4
92 Citations1990Daniel M. Musher, B. J. Johnson +1 more
The hypothesis that only serotype-specific antibody that remains after adsorption with CWPS provides protection against pneumococcal infection is validated and current concepts regarding the presence of antipneumococcal antibody in the unvaccinated population, responses to pneumococal vaccination, and protective levels of immunoglobulin G are reassessed.
Journal of Clinical MicrobiologySerological typing of Branhamella catarrhalis strains on the basis of lipopolysaccharide antigens
91 Citations1990Mario Vaneechoutte, Gerda Verschraegen +2 more
A total of 302 strains of Branhamella catarrhalis from different parts of the world were serologically typed according to their lipopolysaccharide (LPS) antigenicity, and it was shown that 93.4% of the strains tested carried one of three possible LPS types.
The American Journal of MedicineVariables associated with changes in spirometry in patients with obstructive lung diseases
90 Citations1979Richard E. Kanner, Attilio D. Renzetti +3 more
More favorable rates of change of the FVC and FEV1 were associated with a higher alpha1-antitrypsin level and older age, and less favorable changes wereassociated with more years of cigarette smoking, more airway reactivity and more frequent lower respiratory tract illnesses.
Infection and ImmunityMolecular conservation of the P6 outer membrane protein among strains of Haemophilus influenzae: analysis of antigenic determinants, gene sequences, and restriction fragment length polymorphisms
89 Citations1991Michael Nelson, Robert S. Munson +4 more
P6 should receive serious consideration for inclusion in a vaccine to prevent infections caused by nontypeable H. influenzae, and three independent series of experiments indicated that the P6 protein is highly conserved among strains of H. influences.
The Journal of Infectious DiseasesComparison of the Outer Membrane Proteins of 50 Strains of Branhamella catarrhalis
88 Citations1988L C Bartos, Timothy F. Murphy
The outer membrane proteins (OMPs) of 50 strains of B. catarrhalis were examined using sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) to find strikingly homogeneous patterns; there was minimal variability in the MW of OMPs between strains.
Microbial PathogenesisIsolation of the outer membrane of Branhamella catarrhalis
88 Citations1989Timothy F. Murphy, Marilyn R. Loeb
Isolating and partially characterizing the OM of B. catarrhalis represents an initial step in a systematic study of outer membrane antigens of the bacterium.
Clinical Infectious DiseasesPneumococcal Polysaccharide Vaccines
87 Citations1989Robert Austrian
Current investigations suggest that administration of polyvalent vaccines of polysaccharide-protein conjugates in infancy followed by the administration of vaccines of purifiedpolysaccharides after the age of 10 years offers the prospect of reducing significantly the incidence of pneumococcal infections.
Infection and ImmunitySurface-exposed and antigenically conserved determinants of outer membrane proteins of Branhamella catarrhalis
87 Citations1989Timothy F. Murphy, L C Bartos
It is demonstrated that OMP E and OMP G express determinants that are exposed on the surface of the intact bacterium that are antigenically conserved among a majority of strains of B. catarrhalis.
The LancetHqMOPHILUS INFLUENZq AND HqMOPHILUS PARAINFLUENZq IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE
85 Citations1976C. B. Smith
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84 Citations1968A. Pines, H. Raafat +3 more
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84 Citations1967E C Gotschlich, Teh‐Yung Liu
It has been shown that there exists in human pleural and peritoneal fluids an enzyme or a set of enzymes capable of selectively removing the peptide from the pneumococcal mucopeptide, and it has been possible to prepare a polymer which on acid hydrolysis yields only muramic acid, muramic Acid phosphate, and glucosamine, but no amino acids.
Research Portal (King's College London)A rapid method for the differentiation of Haemophilus strains. The porphyrin test.
82 Citations1974Mogens Kilian
Journal of Medical MicrobiologyLoss of ciliary activity in organ cultures of rat trachea treated with lipo-oligosaccharide from Haemophilus influenzae
78 Citations1986Alan P. Johnson, Thomas J. Inzana
Organ culture of rat trachea was used as an experimental model to examine the ability of lipo-oligosaccharide from Haemophilus influenzae to damage respiratory tract mucosal tissue.
Infection and ImmunityHuman bactericidal antibody response to outer membrane protein P2 of nontypeable Haemophilus influenzae
77 Citations1988Timothy F. Murphy, L C Bartos
It is concluded that P2 is a target for human bactericidal antibody and that some of these determinants that are recognized by human bactericide antibody are conserved among strains of nontypeable H. influenzae.
American Review of Respiratory DiseaseThe Effect of Bacterial Products on Ciliary Function
74 Citations1988Robert Wilson, Peter Cole
It is postulated that rapidly acting factors may be involved during bacterial colonization, allowing the bacterium time to penetrate the mucociliary barrier and reach putative receptors on the epithelial surface and facilitate contiguous spread through the bronchial tree.
The Journal of Infectious DiseasesChanges in Outer Membrane Proteins of Nontypable Haemophilus influenzae in Patients with Chronic Obstructive Pulmonary Disease
73 Citations1988K Groeneveld, L van Alphen +3 more
In patients with COPD, the MOMPs of H. influenzae are subject to changes that may enable this bacterium to escape immunological defense mechanisms, and these changes are found in proteins b,c and d.
BMJIncrease in bronchopulmonary infection due to branhamella catarrhalis.
73 Citations1986D T McLeod, Fareed Ahmad +4 more
A survey of the antibiotic prescribing habits of the referring general practitioners together with the sensitivity results of B catarrhalis suggest that changes in antibiotics prescribing habits in the community may be responsible for the increase in B catARRhalis infection.
The Journal of ImmunologyBlood clearance by anti-phosphocholine antibodies as a mechanism of protection in experimental pneumococcal bacteremia.
70 Citations1984Larry S. McDaniel, W H Benjamin +2 more
It is demonstrated that both passive and naturally occurring anti-PC antibodies promote the clearance of S. pneumoniae from the blood, suggesting that the ability to protect against pneumococcal infection with anti- PC antibody is dependent on an artifact associated with either their in vitro growth or the harvesting procedure.
Archives of Internal MedicineBranhamella (Neisseria) catarrhalis systemic disease in humans. Case reports and review of the literature
70 Citations1981Gary V. Doern
A brief review of the literature elucidating the disease entities with which Branhamella (Neisseria) catarrhalishas been associated is presented, and optimal antimicrobial therapeutic regimens are discussed.
American Review of Respiratory DiseaseAn Animal Model Demonstration of Enhanced Clearance of Nontypable <i>Haemophilus influenzae</i> from the Respiratory Tract after Antigen Stimulation of Gut-associated Lymphoid Tissue
69 Citations1989F J Wallace, Robert Clancy +1 more
No clear correlation between local or systemic antibody and bacterial clearance was demonstrated; however, immunized rats were shown to have faster recruitment of phagocytic cells to the bronchial spaces, and these phagocytes had a higher activity state than cells harvested from nonimmunized animals.
BMJFive-year winter chemoprophylaxis for chronic bronchitis
68 Citations1969R.N. Johnston, R. S. McNeill +6 more
There was a significant reduction in the number of exacerbations among the more susceptible patients—that is, those who suffered more than one exacerbation each winter and there was no significant difference between the groups in respect of lung volumes, diffusing capacity, and blood gases.
The Journal of Infectious DiseasesDifferences of Pathophysiology in Experimental Meningitis Caused by Three Strains of Streptococcus Pneumoniae
65 Citations1991M G Täuber, Margaret Burroughs +4 more
The widely different abilities of strains of Streptococcus pneumoniae to induce intracranial abnormalities suggest that virulence determinants affect not only evasion of defense during colonization and invasion, as shown in other models, but also determine the course of disease once infection has been established.
CHEST JournalA Technique for Isolated Airway Segment Lavage
61 Citations1987William L. Eschenbacher, Thomas R. Gravelyn
Cellular composition of the lavages demonstrated differences in cell differential and total cell counts for the two different sampled regions (central airway vs alveolar spaces).
The Journal of Infectious DiseasesAntibiotic-Resistant Isolates of Streptococcus pneumoniae from Clinical Specimens: A Cluster of Serotype 19A Organisms in Brooklyn, New York
60 Citations1986Michael S. Simberkoff, Marcin Łukaszewski +7 more
Ten of 294 isolates of Streptococcus pneumoniae from patients enrolled in a Veterans Administration Cooperative Studies Program trial of pneumococcal vaccine efficacy were moderately resistant or resistant to penicillin.
Journal of GerontologyImmune Response of Elderly Adults to Pneumococcus: Variation by Age, Sex, and Functional Impairment
57 Citations1987Klaus J. Roghmann, P. A. Tablosk +2 more
It is concluded that sex differences persist even among elderly adults, that high levels of antibodies are not necessarily an indicator of good health, and that much unexplained variation between antibody types exist.
Infection and ImmunityPurification and analysis with monoclonal antibodies of P2, the major outer membrane protein of nontypable Haemophilus influenzae
56 Citations1988Timothy F. Murphy, L C Bartos
Observations from purifying and analyzing P2 with particular emphasis on detection of antigenic determinants expressed on the bacterial surface and identification of bactericidal targets on P2 have potentially important implications regarding the development of vaccines to prevent H. influenzae infections and theDevelopment of a serotyping system for epidemiologic studies.
BMJChemotherapy in Chronic Bronchitis: Report of the British Tuberculosis Association
56 Citations1960Robert Francis, C.C. Spicer
Clinical Infectious DiseasesThe Host Response to Invasion by Streptococcus pneumoniae: Protection and the Pathogenesis of Tissue Damage
54 Citations1981Richard B. Johnston
In vitro studies and analyses of the immunodeficiency disorders that predispose to infection with Streptococcus pneumoniae indicate that efficient phagocytosis is essential for protection against this organism, and it is likely that the tissue damage of pneumococcal disease also results from the interactions between antibody, complement, andphagocytic cells that permit ingestion.
Annals of Internal MedicinePneumococcal Vaccine and Patients with Chronic Lung Disease
54 Citations1986James H. Williams, KENNETH M. MOSER
Routine vaccination of all patients with chronic lung disease is not warranted, on the basis of available data, and data suggest that the protection provided by the vaccine in healthy persons may be reduced in patients with Chronic lung disease.
Microbial PathogenesisVariation in the molecular weight of PspA (pneumococcal surface protein A) among Streptococcus pneumoniae
53 Citations1990W. D. Waltman, Larry S. McDaniel +2 more
The Mr of PspA of a given strain was found to be stable both in vivo and in vitro, which should allow discrimination between strains within a given capsular type in epidemiologic studies.
Infection and ImmunityA recombinant non-fatty acylated form of the Hi-PAL (P6) protein of Haemophilus influenzae elicits biologically active antibody against both nontypeable and type b H. influenzae
53 Citations1990B A Green, Benjamin J. Metcalf +4 more
Results demonstrate that purified rPAL elicits antibodies with biological activities that are similar to those of anti-Hi-PAL antibodies, demonstrating that the lipid component of Hi-Pal is not required for either immunogenicity or elicitation of biologically active antibodies.
The Journal of ImmunologyResistance to <i>Streptococcus</i> pneumoniae is induced by a phosphocholine-protein conjugate.
49 Citations1983S C Wallick, J L Claflin +1 more
Induced immunity appeared to be antibody-mediated; it could be passively transferred with immune serum, and absorption of the immune serum with PC-Sepharose removed its protective capacity.
Journal of Clinical MicrobiologyEvaluation of restriction endonuclease analysis as an epidemiologic typing system for Branhamella catarrhalis
47 Citations1989Jan E. Patterson, Thomas F. Patterson +3 more
Chromosomal REA appears to be a useful technique for distinguishing B. catarrhalis strains from nosocomial outbreak strains.
The Journal of ImmunologyBinding of C-reactive protein to the pneumococcal capsule or cell wall results in differential localization of C3 and stimulation of phagocytosis.
45 Citations1984Timothy J. Holzer, Kathryn M. Edwards +2 more
The site of CRP binding and subsequent complement activation may be critical in the opsonophagocytosis of S. pneumoniae, and the correlation between capsular C3 and opsonization to a nonimmune system is extended.
International Journal of Systematic BacteriologyProposal to Divide the Genus Moraxella Lwoff 1939 emend. Henriksen and Bovre 1968 into Two Subgenera, Subgenus Moraxella (Lwoff 1939) Bovre 1979 and Subgenus Branhamella (Catlin 1970) Bovre 1979
45 Citations1979K Bøvre
Strain 199/55 (= ATCC 33078 = NCTC 11227) is here proposed as the neotype strain of Moraxella (Branhamella) ovis, which is presently proposed as a compromise so as to facilitate communication between adherents to these different taxonomies.
Infection and ImmunityApplication of multilocus enzyme gel electrophoresis to Haemophilus influenzae
44 Citations1986O. Porras, Dominique A. Caugant +2 more
Multilocus enzyme electrophoresis showed several advantages over previous typing techniques and could be assigned to both typable and nontypable (NT) isolates, and was powerful in resolving differences among isolates.
Infection and ImmunityImmune enhancement of pulmonary clearance of nontypable Haemophilus influenzae
43 Citations1988E J Hansen, David A. Hart +2 more
Results indicate that systemic immunization can enhance the ability of experimental animals to clear NTHI from the lower respiratory tract and suggest that immunoprophylaxis of NTHi pulmonary disease may be feasible.
Journal of Clinical MicrobiologyIsolation of Branhamella catarrhalis from sputum and tracheal aspirate
41 Citations1983John Aitken, P E Thornley
Branhamella catarrhalis was suggested by the presence of gram-negative intracellular diplococci and confirmed by quantitative culture of the expectorated sputa of 11 patients with clinical evidence of lower respiratory tract infection.
American Journal of EpidemiologyTHE RELATIONSHIP OF ACUTE RESPIRATORY ILLNESS HISTORY TO THE PREVALENCE AND INCIDENCE OF OBSTRUCTIVE LUNG DISORDERS
41 Citations1977Michael D. Lebowitz, Benjamin Burrows
It has been determined that both the previous and subsequent history of ARI are significantly associated with the prevalence and incidence of airways obstructive diseases, those diagnosed by physicians and those inferred by symptoms.
The Pediatric Infectious Disease JournalThe surface of Branhamella catarrhalis
41 Citations1989Timothy F. Murphy
Preliminary studies indicate that OMPs and LOS are relatively antigenically conserved among strains and future investigations should be directed toward identifying conserved antigens that will generate protective antibodies.
The Journal of Infectious DiseasesRestriction Fragment Mapping of Branhamella catarrhalis: A New Tool for Studying the Epidemiology of This Middle Ear Pathogen
40 Citations1988Douglas Dickinson, B. G. Laos +2 more
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