Diethyldithiocarbamate (antabuse): Decrease of brain heavy metal staining pattern and improved consilidation of shuttle ☐ avoidance in goldfish
Brain ResearchPublished 1 January 1975
Gorm Danscher, E. Fjerdingstad
Citations21
SJR quartileQ2
SJR score0.85
SNIP0.72
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TL;DR
Results suggest that DEDTC has a specific facilitating effect on memory consolidation, and suggest that the effect of a single treatment is reversible, and its magnitude and duration dependent on the concentration of DED TC.
Abstract
Abstract Diethyldithiocarbamate (DEDTC), a chelating compound considered to be the active metabolite of the antialcoholic drug Antabuse, abolishes the Timm staining for heavy metals in the brains of goldfish kept in solutions of DEDTC for periods of one hour. The effect of a single treatment is reversible, and its magnitude and duration dependent on the concentration of DEDTC. Fish exposed to DEDTC solutions immediately after a first training session in a shuttle ☐ avoidance task were found to perform significantly better in a second session 24 h later. DEDTC treatment 24 h before the first session, or with a delay of several hours after the first session, was without effect. These results suggest that DEDTC has a specific facilitating effect on memory consolidation.
Keywords
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