HIV envelope glycoprotein, antigen specific T-cell responses, and soluble CD4
The LancetPublished 1 April 1990
Fabrizio Manca, Angus Dalgleish, J A Habeshaw
Citations95
SJR quartileQ1
SJR score12.11
SNIP22.72
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TL;DR
Specific T cells stimulated by antigen presenting cells (APC) pulsed with antigen in the presence of HIV were no longer detectable with a functional assay, which suggests that HIV has been transferred from APC to the specific activated T cell via an antigen-dependent mechanism to exert its cytopathic effect on activated T cells.
Abstract
Specific T cells stimulated by antigen presenting cells (APC) pulsed with antigen in the presence of HIV were no longer detectable with a functional assay, which suggests that HIV has been transferred from APC to the specific activated T cell via an antigen-dependent mechanism to exert its cytopathic effect on activated T cells. In contrast soluble gp120 inhibited antigen-driven proliferation, but this action was reversible and could be blocked by soluble CD4. Thus the chief mechanism of HIV pathogenesis may be gp120/CD4 interaction and HIV may be pathogenic mainly as a producer of gp120.
Keywords
Immunology and MicrobiologyMedicine
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