In vivo cocaine administration influences lymphokine production and humoral immune response
Immunologic ResearchPublished 1 March 1992
Paolo Di Francesco, Stefano Marini, Francesca Pica, Cartesio Favalli, E Tubaro, Enrico Garaci
Citations38
SJR quartileQ2
SJR score0.91
SNIP0.74
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TL;DR
It was found that cocaine inhibits T-dependent antibody production only and this inhibition was greatest when cocaine was given during immunization, suggesting that T-cell-mediated responses may be more affected by cocaine use/abuse.
Abstract
The effect of in vivo cocaine administration on in vitro mitogen-induced lymphokine production was examined. Splenocyte cultures from BALB/c mice treated with an acute (1 mg/kg) or daily cocaine administration (1 mg/kg/day for 7 consecutive days) were less responsive to induction of IFN-gamma, IL-2 and IL-4 production by mitogen stimuli. We also evaluated the humoral immune response to both a T-dependent (HEL) and a T-independent antigen (rHBcAg). It was found that cocaine inhibits T-dependent antibody production only. This inhibition was greatest when cocaine was given during immunization. The results suggest that T-cell-mediated responses may be more affected by cocaine use/abuse.
Keywords
Immunology and MicrobiologyNeuroscience
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