Titin isoform expression in normal and hypertensive myocardium
Cardiovascular ResearchPublished 19 May 2003
Chris Warren
Citations123
SJR quartileQ1
SJR score3.95
SNIP2.66
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TL;DR
Regression analysis of titin isoform ratios, myosin heavy chain isoforms ratios, and heart weight to body weight ratios all suggest a smaller proportion of N2BA titin (longer isoform) was expressed in rat left ventricles with increased hypertrophy.
Abstract
Expression of less N2BA and more N2B titin in response to pressure overload will result in higher passive tension upon stretch at a given sarcomere length and thus affect cardiac performance.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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