Parallele Festphasensynthesen durch Ugi‐Mehrkomponentenkondensation
Angewandte ChemiePublished 15 March 1996
Paul Tempest, S. David Brown, Robert W. Armstrong
Citations16
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Abstract
Zahl und Zugänglichkeit der Ausgangsverbindungen bestimmen die durch Mehrkomponentenreaktionen erzielbare Strukturvielfalt: So wurden an einem aminofunktionalisierten Harz (P) aus 8 Aldehyden, 12 Carbonsäuren und 1 Isocyanid 88 der gewünschten α‐Acylaminoamide parallel synthetisiert [Gl. (a)]. Weitere, kommerziell nicht erhältliche Isocyanide sind aus α‐lithiiertem Benzylisonitril zugänglich und können ohne Reinigung eingesetzt werden. R 1 , R 2 = Alkyl, Aryl. magnified image
Keywords
ChemistryBiochemistry, Genetics and Molecular Biology
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