Depletion of latent HIV-1 infection in vivo: a proof-of-concept study
The LancetPublished 1 August 2005Open access
Ginger Lehrman, Ian B. Hogue, Sarah Palmer, Cheryl Jennings, Celsa A. Spina, Ann Wiegand
Citations508
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TL;DR
Combination therapy with an HDAC inhibitor and intensified HAART safely accelerates clearance of HIV from resting CD4+ T cells in vivo, suggesting a new and practical approach to eliminate HIV infection in this persistent reservoir.
Abstract
Combination therapy with an HDAC inhibitor and intensified HAART safely accelerates clearance of HIV from resting CD4+ T cells in vivo, suggesting a new and practical approach to eliminate HIV infection in this persistent reservoir. This finding, though not definitive, suggests that new approaches will allow the cure of HIV in the future.
Keywords
Immunology and MicrobiologyMedicine
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