Nanosuspensions in drug delivery
Nature Reviews Drug DiscoveryPublished 1 September 2004
Barrett Rabinow
Citations1,494
SJR quartileQ1
SJR score30.51
SNIP23.21
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TL;DR
Water insolubility issues of the past have provoked a paradigm change, which now offers novel solutions for innovative drugs of the future, and additional pharmacokinetic benefits of the drugs so formulated have come to be appreciated.
Abstract
A surprisingly large proportion of new drug candidates emerging from drug discovery programmes are water insoluble, and therefore poorly bioavailable, leading to abandoned development efforts. These so-called 'brickdust' candidates can now be rescued by formulating them into crystalline nanosuspensions. In the process of overcoming issues involving solubility, additional pharmacokinetic benefits of the drugs so formulated have come to be appreciated. As such, insolubility issues of the past have provoked a paradigm change, which now offers novel solutions for innovative drugs of the future.
Keywords
Materials SciencePharmacology, Toxicology and Pharmaceutics
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