Ultrastructural changes in rat lung during long-term exposure to oxygen.
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TL;DR
The pathogenesis of oxygen toxicity in the lung of rats was studied by electron microscopy and eventual subsiding of the interstitial edema in surviving rats with a concomitant development of emphysema was established.
Abstract
The pathogenesis of oxygen toxicity in the lung of rats was studied by electron microscopy. The following long-term effects were established: (1) a progressive destruction of the blood-air barrier beginning with the endothelial cell layer; (2) a profuse edema in the interstitial spaces in the pleural space in the alveoli and in the cytoplasm and organelles; (3) a continuing increase in the quantity and complexity of the alveolar exudate; (4) gradual hemolysis of red blood cells; and (5) eventual subsiding of the interstitial edema in surviving rats with a concomitant development of emphysema.