Physiologic Abnormalities of Salicylate Intoxication
New England Journal of MedicinePublished 18 December 1958
William E. Segar, Malcolm A. Holliday
Citations60
SJR quartileQ1
SJR score19.08
SNIP13.47
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
The clinical manifestations to be discussed in terms of altered physiology include hyperpyrexia, transient hyperglycemia, respiratory alkalosis, metabolic acidosis, dehydration and hypernatremia.
Abstract
THE following report consists of observations on the physiologic abnormalities produced by salicylate intoxication in a series of 49 infants and children. It presents a summary of the specific physiologic changes illustrated in this clinical experience and examines some of the factors important to the development of these dysfunctions.The clinical manifestations to be discussed in terms of altered physiology include hyperpyrexia, transient hyperglycemia, respiratory alkalosis, metabolic acidosis, dehydration and hypernatremia. Reference is made to work that elucidates the mechanisms leading to the observed disorders, and our clinical experience is described within this context.Case MaterialForty-nine children were seen . . .
Keywords
Medicine
Journal of Clinical InvestigationON DIABETIC ACIDOSIS
397 Citations1933Dana W. Atchley, Robert F. Loeb +3 more
BMJAspirin and Diabetes Mellitus
184 Citations1957James Reid, A.I. Macdougall +1 more
Primary suture proved an unreliable operation, although some good results were seen, and most of the repairs reported were secondary.
PEDIATRICSHYPERNATREMIA IN INFANTS
144 Citations1955Laurence Finberg, Harold E. Harrison
It has been shown that hypernatremia may accompany dehydration in infants with diarrhea and with infections associated with interference with water intake, and suitable modification of the treatment dehydration for these patients has appeared to improve the results of their care.
Archives of Internal MedicineINTERMITTENT PERITONEAL LAVAGE IN NEPHRECTOMIZED DOGS AND ITS APPLICATION TO THE HUMAN BEING
135 Citations1951Arthur P. Grollman
Peritoneal lavage has been possible to maintain bilaterally nephrectomized dogs for periods of 30 to 70 days, which is several times that ever reported previously, with consideration of the inevitable malignant hypertension that develops following.
PEDIATRICSHYPERTONIC DEHYDRATION IN INFANCY
118 Citations1956William B. Weil, William M. Wallace
This article points out certain areas of clinical significance that may serve to identify the hypertonic group of infants from a population of dehyradated children to demonostrate some of the pathologic physiology of the condition and to help indicate optimal therapeutic procedures.
The American Journal of MedicineThe respiratory and circulatory actions of salicylate
117 Citations1955S.M. Tenney, Renee M. Miller
It is concluded that this is a direct cardiac muscle effect of salicylate, and the principal change in acid-base balance in the intact dog and adult human is the development of respiratory alkalosis.
QJMMetabolic Studies in Severe Diabetic Ketosis
115 Citations2015J. D. N. Nabarro, A G Spencer +1 more
Biochemical JournalThe effect of salicylate and cinchophen on enzymes and metabolic processes
101 Citations1942Cecilia Lutwak‐Mann
A study was made of the effect of salicylate and cinchophen, first on the in vitro activity of isolated tissues and enzyme systems, and secondly on certain metabolic processes in the intact animal (rat).
Journal of Clinical InvestigationThe Renal Response in Man to Acute Experimental Respiratory Alkalosis and Acidosis1
94 Citations1957Erin Barker, R. B. Singer +2 more
Findings in anesthetized dog experiments differ from the return to control values after hyperventilation noted in humans in studies and those of Stan- bury and Thomson (20).
BMJRespiratory Effects of Salicylate
63 Citations1952Joel B. Cochran
The rapid oxygenation of the asphyxiated, as shown by skin colour, the movement -of the chest wall, and the showers of fine crepitations on auscultation at each insufflation, suggested that the alveoli themselves were being expanded.
Biochemical JournalThe effect of salicylate on glycosuria, blood glucose and liver glycogen of the alloxan-diabetic rat
60 Citations1952M. J. H. Smith, B. W. Meade +1 more
The recent report of Ingle (1950) that aspirin reduced the glycosuria of rats made mildly diabetic by partial pancreatectomy stimulated us to investigate this effect in more detail.
Archives of Biochemistry and BiophysicsEffects of salicylate and other benzoates on oxidative enzymes of the tricarboxylic acid cycle in rat tissue homogenates
57 Citations1954E.H. Kaplan, Jean Kennedy +1 more
Salicylate and related compounds inhibit the Krebs cycle in kidney and liver homogenates and the oxidative enzymes inhibited to the greatest extent are α-ketoglutaric dehydration and succinic dehydrogenase.
American Journal of Diseases of ChildrenSALICYLATE POISONING
54 Citations1945MARY MAHER TROLL
Although the administration of salicylates is commonly not associated with untoward effects, occasionally therapy with these drugs may be accompanied by medical hazards for patients who have an idiosyncrasy or susceptibility to these drugs.
Experimental Biology and MedicineHypoprothrombinemia After Salicylate Administration in Man and Rabbits
48 Citations1943С. И. Рапопорт, Mary Wing +1 more
During investigations on the effects of large doses of salicylates on the electrolyte structure of the blood, to be reported elsewhere, it was noted that a number of Salicylate-intoxicated rabbits died of pericardial hemorrhage following heart puncture, and that their blood sometimes required a long time to clot.
The Journal of PediatricsSalicylate intoxication in infants and children
39 Citations1942Henry L. Barnett, John R. Powers +2 more
The importance of glycogen depletion specifically associated with the increased metabolic activity due to salicylates in the development of ketosis and acidosis is suggested, and the effect of this on prevention and treatment of the intoxication is discussed.
Journal of Pharmacy and PharmacologySOME RECENT ADVANCES IN THE PHARMACOLOGY OF SALICYLATES
36 Citations1953Michael Smith
The aim of the present article is to supplement this by discussing certain selected topics which have received attention in recent years of the pharmacology of salicylates.
Journal of Clinical InvestigationTHE EFFECT OF SALICYLATES ON THE ELECTROLYTE STRUCTURE OF THE BLOOD PLASMA. I. RESPIRATORY ALKALOSIS IN MONKEYS AND DOGS AFTER SODIUM AND METHYL SALICYLATE; THE INFLUENCE OF HYPNOTIC DRUGS AND OF SODIUM BICARBONATE ON SALICYLATE POISONING1
35 Citations1945S. Rapoport, George M. Guest
The clinical picture typical of salicylate poisoning has often been described: hyperpnea appears to be the most prominent symptom; other symptoms are vomiting, thirst, sweating, diuresis, fever, and various signs of irritation of the central nervous system, including convulsions followed by depression and coma.
Archives of Pediatrics and Adolescent MedicineSALICYLATE POISONING: AN EXPLANATION OF THE MORE SERIOUS MANIFESTATIONS
33 Citations1937Katharine Dodd
The numerous reports in the literature of poisoning due to Salicylates apart from manifestations of an allergic idiosyncrasy to the drug indicate that salicyl compounds are not always the harmless household remedy that they are generally supposed to be.
The Journal of PediatricsStudies of 17-hydroxycorticosteroids
31 Citations1954Alan K. Done, Robert S. Ely +1 more
The Journal of PediatricsRetention of water and electrolyte during recovery in a patient with diabetic acidosis
28 Citations1952Daniel C. Darrow, Edward L. Pratt
Although potassium deficits are moderate, the effects of insulin are likely to produce a rapid and dangerous decrease in serum potassium concentration, and potassium should be administered as soon as insulin begins to reduce blood sugar.
Experimental Biology and MedicineInfluence of Acetylsalicylic Acid (Aspirin) on Urinary Excretion of Ascorbic Acid
24 Citations1936A. L. Daniels, Gladys J. Everson
To obtain further data regarding the effect of aspirin on vitamin C metabolism in the human organism, the 3 children between 4 and 6 years of age who were under observation were given constant weighed diets during which period the ascorbic acid intakes and excretions were determined daily.
Experimental Biology and MedicineCarbohydrate Metabolism in Experimental Salicylism.
23 Citations1955Robert W. Winters, Mary F. Morrill
Fasting rats given large doses of sodium salicylate fail to deposit liver glycogen even when they are given a major stimulus for such deposition in the form of Compound F, yet such animals continue to break down body protein at an accelerated rate as judged by the nitrogen balances.
Archives of Disease in ChildhoodThe Value of Alkali in Salicylate Therapy
20 Citations1931Noah Morris, Stanley Graham
PEDIATRICSCORTICOIDS IN SERUM OF CHILDREN WITH TREATED DIABETES MELLITUS
19 Citations1956Ronald Klein, F. A. Weigand +2 more
Free serum corticoids in children with treated diabetes mellitus were found to be significantly higher than those in normal children and was directly related to the amount of reducing substances found in the urine.
BMJA Case of Aspirin Poisoning
12 Citations1944Alan Charters
The returning prisoner of war is ill equipped for the difficult period of readjustment, resulting in the inevitable appearance of more serious neurotic symptoms and loss of morale and of personal drive.
EndocrinologyTHE EFFECT OF ASPIRIN UPON THE GLYCOSURIA OF PARTIALLY DEPANCREATIZED RATS IN THE PRESENCE AND ABSENCE OF THE ADRENAL GLANDS
12 Citations1953Dwight J. Ingle, D. F. Beary +1 more
It is shown that large doses of aspirin ameliorate the diabetes of partially depancreatized rats in both the presence and absence of the adrenal glands.
The Journal of PhysiologyA Contribution to our Knowledge of the Action of Certain Drugs upon Bodily Temperature
10 Citations1882Horatio C. Wood, Edward Tyson Reichert
The present memoir is therefore incomplete, but is published because the labour involved in this kind of investigation is so great that few are willing to undergo it, and any solid work is of corresponding value.
New England Journal of MedicineDifferential Diagnosis of Salicylate Intoxication and Diabetic Acidosis
10 Citations1956Alan S. Cohen
As increasing numbers of potent pharmacologic agents become available for general use, the chance of accidentally induced toxicity increases and the clinical and laboratory abnormalities that occur are quite similar in many respects to those of diabetic acidosis.
Journal of the American Medical AssociationACIDOSIS IN METHYL SALICYLATE POISONING
9 Citations1928J. G. M. OLMSTED, C. Anderson Aldrich
The recent observation of pronounced acidosis occurring in two children after the ingestion of oil of wintergreen (methyl salicylate) has prompted a review of the literature on this subject.
Archives of Internal MedicineANTIPYRETICS. II. ACETYLSALICYLIC ACID AND HEAT REGULATION IN NORMAL INDIVIDUALS
9 Citations1919Henry G. Barbour
The effects of this substance on the heat regulation of normal and of febrile human subjects, respectively, will be dealt with here and in the third paper of the series.
Biochimica et Biophysica ActaThe effect of salicylate on glucose tolerance in the rat
5 Citations1954M. J. H. Smith
It is concluded that salicylate causes increased intestinal absorption of glucose in the rat and causes increased blood glucose concentrations when glucose is given orally but not when it is injected intravenously.
Journal of Pharmacology and Experimental TherapeuticsTHE EFFECT OF SALICYLATE ADMINISTRATION ON THE ACETONE BODY CONTENT OF THE BLOOD
4 Citations1929HAROLD B. MYERS, Charles B. Ferguson
Annals of Internal MedicineGlycosuria and Recovery Following Methyl Salicylate Poisoning
4 Citations1930Elmer L. Sevringhaus, OVID O. MEYER
An outbreak of acute intoxication with methyl salicylate is reported to have been fatal from a dose of one ounce.
Experimental Biology and MedicineAction of Sodium Salicylate on Tissue Gas Tensions.
3 Citations1956Randi Miller, S.M. Tenney
In the rat, sodium salicvlate in doses of 200 mg/kg/24 hr produced a fall in tissue CO2 and O2 tensions, effects due to the increased alveolar ventilation and relatively greater increase of tissue oxygen consumption than tissue perfusion.