SHOULD OSTEOARTHRITIS BE TREATED WITH NONSTEROIDAL ANTI-INFLAMMATORY DRUGS?
Rheumatic Disease Clinics of North AmericaPublished 1 August 1993
Kenneth D. Brandt
Citations35
SJR quartileQ1
SJR score1.12
SNIP1.10
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TL;DR
The uncertainty that exists regarding the use of NSAIDs in the treatment of OA is explored.
Abstract
Numerous studies have demonstrated the efficacy of nonsteroidal anti-inflammatory drugs (NSAIDs) and their superiority to placebo as symptomatic treatment for osteoarthritis (OA). Unquestionably, use of NSAIDs has reduced joint pain and improved mobility for millions of patients with OA. This article explores the uncertainty that exists regarding the use of NSAIDs in the treatment of OA.
Keywords
Medicine
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13 Citations1983
Piroxicam was equally effective when administered in the morning or at night, evidence for the view that a single daily dose relieves symptoms for at least 24 hours is shown.
Journal of Pharmacy and PharmacologyEffect of naproxen sodium on the net synthesis of glycosaminoglycans and protein by normal canine articular cartilage in-vitro
12 Citations1990Kenneth D. Brandt, Marjorie Albrecht
The effects of the non‐steroidal anti‐inflammatory drug, naproxen sodium, on the metabolism of normal canine articular cartilage has been examined and it is suggested that it had no direct effect on the integrity of the extracellular matrix.
The Journal of Clinical PharmacologyEffects of Tiaprofenic Acid on the Concentration and Metabolism of Proteoglycans in Normal and Degenerating Canine Articular Cartilage
11 Citations1990Kenneth D. Brandt, Marjorie Albrecht +1 more
The suppression of net cartilage proteoglycan synthesis caused by immobilization was not affected by administration of TPA nor did the drug affect the proportion of newly synthesized glycosaminoglycans recovered from the spent culture medium, suggesting that it did not increase proteogly can catabolism or affect the integrity of the cartilage matrix.
Journal of Orthopaedic Research®[<sup>99m</sup>Tc]Diphosphonate uptake and hemodynamics in experimental arthritis: Effect of naproxen in the canine carrageenan injection model
9 Citations1992Ebbe Stender Hansen, Shaolong He +5 more
The study suggests that long‐term cyclooxygenase inhibition offers protection against hemodynamic and metabolic changes in juxta‐articular bone secondary to synovial inflammation.
Current Medical Research and OpinionSection 1 Ibuprofen in osteoarthritis
9 Citations1975Joseph E. Giansiracusa, Molla S. Donaldson +4 more
Judged by patient preference for drug or placebo treatment periods, both drugs were found to be superior to placebo and about equally as effective in relieving pain and in improving the ability to perform a selected activity.
Osteoarthritis and CartilageTherapeutic effect of doxycycline (doxy) in canine osteoarthritis (OA)
8 Citations1993
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