Highly enantioselective synthesis of bisoxindoles with two vicinal quaternary stereocenters via Lewis base mediated addition of oxindoles to isatin-derived ketimines
Organic & Biomolecular ChemistryPublished 1 January 2014
Zhongkai Tang, Yan Shi, Haibin Mao, Xuebin Zhu, Weipeng Li, Yixiang Cheng
Citations49
SJR quartileQ2
SJR score0.60
SNIP0.71
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TL;DR
A highly efficient asymmetric organocatalytic addition of 3-substituted oxindole to isatin-derived ketimine is reported with excellent stereocontrol under mild conditions and provides access to the bisoxindole structure moiety with two vicinal quaternary stereogenic centers.
Abstract
A highly efficient asymmetric organocatalytic addition of 3-substituted oxindole to isatin-derived ketimine is reported with excellent stereocontrol (>99 : 1 dr, >99% ee) under mild conditions. This method provides access to the bisoxindole structure moiety with two vicinal quaternary stereogenic centers.
Keywords
Chemistry
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