A molecular variant of angiotensinogen associated with preeclampsia
Nature GeneticsPublished 1 May 1993
Kevin R. Ward, Akira Hata, Xavier Jeunemaı̂tre, Catherine Helin, Lawrence M. Nelson, Chisato Namikawa
Citations504
SJR quartileQ1
SJR score16.59
SNIP6.64
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TL;DR
In a series of Caucasian women with pregnancy–induced hypertension, a significant association of preeclampsia with a molecular variant of angiotensinogen, T235, found previously to be associated with essential hypertension is observed, which support a new pathophysiological interpretation of preeClampsia and of its relation to some forms of essential hypertension.
Abstract
Pregnancy-induced hypertension (PIH) is a heterogeneous disorder which complicates 5-7% of all pregnancies and remains a leading cause of maternal, fetal and neonatal morbidity and mortality. Severe preeclampsia is the most distinctive and life-threatening form; a multi-system disorder more common in first pregnancies, it is characterized by high blood pressure and proteinuria. In a series of Caucasian women with pregnancy-induced hypertension, we have observed a significant association of preeclampsia with a molecular variant of angiotensinogen, T235, found previously to be associated with essential hypertension. This finding is corroborated in a sample ascertained in Japan. Together, these observations support a new pathophysiological interpretation of preeclampsia and of its relation to some forms of essential hypertension.
Keywords
Medicine
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