Time-dependent effects of Metrazol on memory
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TL;DR
It was found that Metrazol given at different intervals before a single passive avoidance training trial produced graded performance impairments 24 hr later and the degree of the resulting amnesia was shown to depend on the temporal proximity of theMetrazol seizures to the training trial.
Abstract
The effects of Metrazol induced seizures on memory were studied in two experiments. In Experiment 1 it was found that Metrazol given at different intervals before a single passive avoidance training trial produced graded performance impairments 24 hr later. The degree of the resulting amnesia was shown to depend on the temporal proximity of the Metrazol seizures to the training trial. In Experiment 2 Metrazol was given immediately following the passive avoidance trial but amnesia was found to develop only after several hr following the Metrazol treatment. The data are similar to those obtained with ECS.