Idiopathic thrombocytopenic purpura in childhood.
PubMedPublished 9 September 1967Open access
Sung Yong Choi, P. D. McClure
Citations59
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Keywords
Medicine
BloodStudies on Thrombopoiesis. I. A Factor in Normal Human Plasma Required for Platelet Production; Chronic Thrombocytopenia Due to its Deficiency
256 Citations1960Irving Schulman, Mila Pierce +2 more
The factor appears to act by stimulating megakaryocyte maturation and platelet production in an orderly and sequential manner, and is stable on storage under normal blood banking conditions and on freezing.
Journal of the American Medical AssociationTREATMENT OF IDIOPATHIC THROMBOCYTOPENIC PURPURA
100 Citations1959Alan F. Carpenter
Splenectomy gave better results than did steroids in the dosages used, but there were three serious postoperative infections, and in one case lupus erythematosus appeared 12 months after the splenectomy.
Annals of Internal MedicineSYSTEMIC LUPUS ERYTHEMATOSUS: A COMPLEX AUTO-IMMUNE DISORDER?
89 Citations1958W Dameshek
Excerpt InTRODUCTION Systemic (disseminated) lupus erythematosus has been known for at least 50 years, but its exact nature and the pathogenetic mechanisms bringing it about are almost as obscure as the disease itself.
A M A Archives of Internal Medicine"IDIOPATHIC" THROMBOCYTOPENIA
76 Citations1951Erwin O. Hirsch
In the many reviews published during the last 15 years the diagnostic features mentioned above have always been emphasized, together with the often dramatic results following splenectomy, and the natural course of the disease has been discussed in relatively few publications.
A M A Journal of Diseases of ChildrenSplenectomy in Infancy and Childhood
73 Citations1956Ralph M. Gofstein
Of five infants splenectomized under 6 months of age, four contracted meningitis (two meningococcal, one Hemophilus influenzae, and one of undetermined type) from 5 to 31 months following splenectomy, while the fifth died of an illness strongly suggesting septicemia 1 month aftersplenectomy.
The Journal of PediatricsStudies on thrombopoiesis
58 Citations1965Irving Schulman, Charles F. Abildgaard +3 more
Plasmas of children with acquired idiopathic thrombocytic purpura contained normal amounts ofThrombopoietic factor, however, 10 of 20 children with acute ITP responded to infusions of large amounts of normal human plasma, thus suggesting that platelet formation in man may be stimulated by excesses of the thromBopoetic factor.
New England Journal of MedicineThe Thrombocytopenic Effect of Sustained High-Dosage Prednisone Therapy in Thrombocytopenic Purpura
53 Citations1961Phin Cohen, Frank H. Gardner
The beneficial effect of corticosteroids in the treatment of idiopathic thrombocytopenic purpura in adults has been proved and the practice in this laboratory has been to taper the dose until the lowest maintenance level is found at which the remission is sustained.
New England Journal of MedicineThrombocytopenic Purpura with Histiocytosis of the Spleen
45 Citations1961Benjamin H. Landing, Lotte Strauss +5 more
The recent independent observation, by several of us, of peculiar histiocytosis of the spleens of patients with "idiopathic" thrombocytopenic purpura has prompted the collection and review of the data.
Archives of Disease in ChildhoodIdiopathic Thrombocytopenic Purpura in Childhood
45 Citations1961John H. Walker, W. Allan Walker
There remains a group of patients with idiopathic thrombocytopenic purpura and it is with this disease only that the present communication is concerned, and it should be emphasized that the mode of onset may be acute in either variety and that spontaneous recovery may occur even after an illness lasting several months.
Archives of SurgerySplenectomy for Idiopathic Thrombocytopenic Purpura
44 Citations1966George E. Block
The disease is distinguished from secondary thrombocytopenic purpura almost by the process of exclusion; there is no history of a preceding infection and toxic exposure to such agents as quinidine or arsenicals and allergic responses are absent.
Archives of Disease in ChildhoodPrognosis in Idiopathic Thrombocytopenic Purpura of Childhood
39 Citations1954G. M. Komrower, G. H. Watson
A number of cases in children are discussed and some other series are reviewed in order to obtain a clearer picture of the course and prognosis of the disease in children.
PEDIATRICSDIAGNOSIS AND TREATMENT: MANAGEMENT OF IDIOPATHIC THROMBOCYTOPENIC PURPURA
38 Citations1964Irving Schulman
It seems clear that the incidence of CNS bleeding is no greater than 2-4% and that in most series reporting a greater incidence cases were not limited to ITP but included instances ofThrombotic thrombocytopenic purPura and purpura fulminans, i.e., disease states associated with vasculitis.
Archives of Pediatrics and Adolescent MedicinePURPURA IN INFANTS AND CHILDREN<subtitle>Its Natural History</subtitle>
29 Citations1953David H. Clement
The increasing frequency of the occurrence of purpura in childhood has made more important an understanding of the natural history of the disease and the problem of proper management of these patients.
Journal of the American Medical AssociationIDIOPATHIC THROMBOCYTOPENIC PURPURA
25 Citations1960William B. Scharfman
The Journal of PediatricsFresh plasma transfusions in the treatment of acute thrombocytopenic purpura
13 Citations1966C. W. Reiquam, J.C. Prosper
Seventeen patients who were treated with fresh plasma transfusions for idiopathicor postinfectious thrombocytopenia are presented, although one patient required two courses of plasma transfusion and another was given corticosteroids after failure of one course of fresh plasma.