The ER-overload response: activation of NF-κB
Trends in Biochemical SciencesPublished 1 February 1997
Heike L. Pahl, Patrick A. Baeuerle
Citations336
SJR quartileQ1
SJR score4.16
SNIP2.34
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TL;DR
Both the release of Ca2+ from the ER and the subsequent production of reactive oxygen intermediates are required for ER-overload-mediated NF-kappa B activation, and this novel intracellular signal transduction pathway might be important in antiviral defense and play a role in various diseases as well as in B-cell development.
Abstract
Various conditions that perturb the function of the endoplasmic reticulum (ER) were recently shown to activate the transcription factor NF-kappa B. Activation of NF-kappa B is caused by the accumulation of proteins in the ER membrane, a condition we have called ER overload. Both the release of Ca2+ from the ER and the subsequent production of reactive oxygen intermediates are required for ER-overload-mediated NF-kappa B activation. This novel intracellular signal transduction pathway might be important in antiviral defense and play a role in various diseases as well as in B-cell development.
Keywords
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