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Effect of Age, Estrogen Status, and Late-Life GPER Activation on Cardiac Structure and Function in the Fischer344×Brown Norway Female Rat

The Journals of Gerontology Series APublished 22 March 2016Open access
A Alencar, Jaqueline da Silva, Marina Lin, Ananssa M Silva, Xuming Sun, Carlos M. Ferrario
Citations52
SJR quartileQ1
SJR score1.33
SNIP1.28
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TL;DR

Findings may explain the preponderance of heart failure with preserved ejection fraction in older postmenopausal women and provide a promising, late-life therapeutic target to reverse or halt the progression of left ventricular diastolic dysfunction.

Abstract

ATPase expression and reductions in interstitial fibrosis. These findings may explain the preponderance of heart failure with preserved ejection fraction in older postmenopausal women and provide a promising, late-life therapeutic target to reverse or halt the progression of left ventricular diastolic dysfunction.

Keywords

Medicine