The anxiogenic action of Ro 15-1788 is reversed by chronic, but not by acute, treatment with chlordiazepoxide
Brain ResearchPublished 1 September 1984
Sandra E. File, Sharon Pellow
Citations36
SJR quartileQ2
SJR score0.85
SNIP0.72
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TL;DR
The benzodiazepine receptor antagonist, Ro 15-1788 (10 mg/kg) is anxiogenic in the social interaction test, and in animals pretreated with chlordiazepoxide for 5 days prior to testing, there was a reduction in the anxiety produced by the drug.
Abstract
The benzodiazepine receptor antagonist, Ro 15-1788 (10 mg/kg) is anxiogenic in the social interaction test. Acute administration of chlordiazepoxide (5 or 10 mg/kg) did not reverse the anxiogenic effects of Ro 15-1788; however, in animals pretreated with chlordiazepoxide (5 mg/kg) for 5 days prior to testing, there was a reduction in the anxiety produced by Ro 15-1788.
Keywords
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