Sleep Symptoms Predict the Development of the Metabolic Syndrome
SLEEPPublished 1 December 2010Open access
Wendy Troxel, Daniel J. Buysse, Karen A. Matthews, Kevin E. Kip, Patrick J. Strollo, Martica H. Hall
Citations272
SJR quartileQ1
SJR score1.80
SNIP1.63
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Difficulty falling asleep, unrefreshing sleep, and, particularly, loud snoring, predicted the development of metabolic syndrome in community adults.
Abstract
Difficulty falling asleep, unrefreshing sleep, and, particularly, loud snoring, predicted the development of metabolic syndrome in community adults. Evaluating sleep symptoms can help identify individuals at risk for developing metabolic syndrome.
Keywords
PsychologyMedicine
JAMAPrevalence of the Metabolic Syndrome Among US Adults
6,698 Citations2002Earl S. Ford, Wayne H. Giles +1 more
These results from a representative sample of US adults show that the metabolic syndrome is highly prevalent and the large numbers of US residents with the metabolic Syndrome may have important implications for the health care sector.
JAMAThe Metabolic Syndrome and Total and Cardiovascular Disease Mortality in Middle-aged Men
5,041 Citations2002Hanna‐Maaria Lakka
Cardiovascular disease and all-cause mortality are increased in men with the metabolic syndrome, even in the absence of baseline CVD and diabetes, according to the Kuopio Ischaemic Heart Disease Risk Factor Study.
Diabetes CareA Prospective Study of Self-Reported Sleep Duration and Incident Diabetes in Women
890 Citations2003Najib Ayas, David P. White +6 more
The data suggest that the association between a reduced self-reported sleep duration and diabetes diagnosis could be due to confounding by BMI, or sleep restriction may mediate its effects on diabetes through weight gain.
American Journal of Respiratory and Critical Care MedicineAssociation of Sleep Apnea and Type II Diabetes
774 Citations2005Kevin J. Reichmuth, Diane Austin +2 more
Investigating the prevalence and incidence of type II diabetes in subjects with SDB found diabetes is more prevalent in SDB and this relationship is independent of other risk factors, however, it is not clear that SDB is causal in the development of diabetes.
SLEEPInsomnia with Objective Short Sleep Duration is Associated with a High Risk for Hypertension
758 Citations2009Alexandros N. Vgontzas, Duanping Liao +3 more
Insomnia with short sleep duration is associated with increased risk of hypertension, to a degree comparable to that of other common sleep disorders, e.g., SDB.
Cardiovascular DiabetologyHuman epicardial adipose tissue expresses a pathogenic profile of adipocytokines in patients with cardiovascular disease
650 Citations2006Adam Baker, Nancy F. da Silva +6 more
Journal of Sleep ResearchComparison between subjective and actigraphic measurement of sleep and sleep rhythms
624 Citations1999Steven W. Lockley, Debra J. Skene +1 more
Actigraphy and sleep logs agreed when assessing changes in sleep in relation to a circadian phase marker (the 6‐sulphatoxymelatonin (aMT6s) rhythm) in both entrained and free‐running subjects.
SLEEPSleep Duration as a Risk Factor for Diabetes Incidence in a Large US Sample
591 Citations2007James E. Gangwisch, Steven B. Heymsfield +7 more
Short sleep duration could be a significant risk factor for diabetes and the association between long sleep duration and diabetes incidence is more likely to be due to some unmeasured confounder such as poor sleep quality.
Psychosomatic MedicineHealthy Older Adults’ Sleep Predicts All-Cause Mortality at 4 to 19 Years of Follow-Up
580 Citations2003Mary Amanda Dew, Carolyn C. Hoch +7 more
Older adults with specific EEG sleep characteristics have an excess risk of dying beyond that associated with age, gender, or medical burden, and the findings suggest that interventions to optimize and protect older adults’ sleep initiation, continuity, and quality may be warranted.
SLEEPA Survey Screen for Prediction of Apnea
488 Citations1995Greg Maislin, Allan I Pack +6 more
Questionnaire data from patients presenting at three sleep disorders centers were used to develop and assess a screening tool for sleep apnea based on the reporting of the frequency of various symptoms ofsleep apnea and other sleep disorders plus age, body mass index (BMI) and gender.
Biological PsychiatrySleep Loss Activates Cellular Inflammatory Signaling
452 Citations2008Michael R. Irwin, Minge Wang +6 more
These results identify NF-kappaB activation as a molecular pathway by which sleep disturbance may influence leukocyte inflammatory gene expression and the risk of inflammation-related disease.
SLEEPSelf-Reported Sleep Duration is Associated with the Metabolic Syndrome in Midlife Adults
449 Citations2008Martica H. Hall, Matthew F. Muldoon +4 more
Data suggest that sleep duration is a significant correlate of the metabolic syndrome, which is a cluster of physiologically interrelated risk factors for cardiometabolic disease.
Behavioral Sleep MedicineInsomnia as a Health Risk Factor
443 Citations2003Daniel J. Taylor, Kenneth L. Lichstein +1 more
The data were inconclusive regarding insomnia as a risk factor for cardiovascular disease and mortality, but sleep medication use was predictive of mortality and insomnia was related to decreased immune functioning.
Endocrinology and Metabolism Clinics of North AmericaSleep, the hypothalamic–pituitary–adrenal axis, and cytokines: multiple interactions and disturbances in sleep disorders
410 Citations2002Alexandros N. Vgontzas, George P. Chrousos
Findings suggest that the HPA axis stimulates arousal, while IL-6 and TNF-alpha are possible mediators of excessive daytime sleepiness in humans.
American Journal of Respiratory and Critical Care MedicineProspective Study of Sleep-disordered Breathing and Hypertension: The Sleep Heart Health Study
388 Citations2009George O'connor, Brian Caffo +7 more
Among middle-aged and older persons without hypertension, much of the relationship between AHI and risk of incident hypertension was accounted for by obesity, and after adjustment for body mass index, the AHI was not a significant predictor of future hypertension.
SLEEPSelf-reported Sleep Quality is Associated With the Metabolic Syndrome
342 Citations2007J. Richard Jennings, Matthew F. Muldoon +3 more
Self-reported global sleep quality is significantly related to the metabolic syndrome and several of its core components.
Medicine & Science in Sports & ExerciseValidity and reliability of self-reported physical activity status: the Lipid Research Clinics questionnaire
333 Citations1993Barbara E. Ainsworth, David R. Jacobs +1 more
The LRC PA questionnaire is a relatively valid and reliable indicator of heavy PA in adults and the four-point method increases the ability to show graded associations between measures of cardiorespiratory fitness, body fatness, and leisure time PA.
Diabetes CareIncidence of Diabetes in Middle-Aged Men Is Related to Sleep Disturbances
324 Citations2004Peter M. Nilsson, Mattias Rööst +3 more
The results suggest that sleep disturbances and, possibly, elevated resting heart rate, in middle-aged men, are associated with an increased risk of diabetes.
SLEEPHeavy Snoring as a Cause of Carotid Artery Atherosclerosis
265 Citations2008Sharon A. Lee, Terence C. Amis +5 more
Heavy snoring significantly increases the risk of carotid atherosclerosis, and the increase is independent of other risk factors, including measures of nocturnal hypoxia and obstructive sleep apnea severity.
Diabetes CareSleep Disturbance and Onset of Type 2 Diabetes
242 Citations2004Norito Kawakami, Naoyoshi Takatsuka +1 more
This work investigated the association between sleep disturbance and the subsequent onset of type 2 diabetes in a group of Japanese women and indicated an interesting association betweenSleep patterns and later-onset type 2 Diabetes.
Cardiovascular DiabetologyObstructive sleep apnoea is independently associated with the metabolic syndrome but not insulin resistance state
191 Citations2006András Gruber, F. Horwood +3 more
OSA is associated with MS independent of obesity predominantly due to increased triglyceride, glucose and Epworth score values but not IR or microalbuminuria status, suggesting an alternative pathogenic factor mediating the increased cardiovascular risk in patients with OSA and MS, other than that due to IR.
Journal of Clinical Sleep MedicinePsychometric Evaluation of the Insomnia Symptom Questionnaire: a Self-report Measure to Identify Chronic Insomnia
187 Citations2009Michele L. Okun, Howard M. Kravitz +4 more
The high specificities suggest that the ISQ has a high probability of correctly identifying those without insomnia and would be a cost-effective tool in large observational studies in which the prevalence of insomnia is likely to be about 10%.
Journal of Behavior Therapy and Experimental PsychiatryCatastrophic worry in primary insomnia
139 Citations2003Allison G. Harvey, Emmeline Greenall
An empirical test of the proposal that catastrophic worry about the consequences of not sleeping is common among patients with primary insomnia and serves to maintain the sleep disturbance suggests that this worry is associated with increased negative affect and increased perception of threat.
Current Hypertension ReportsMediators of sympathetic activation in metabolic syndrome obesity
124 Citations2008Nora E. Straznicky, Nina Eikelis +2 more
Accumulated evidence based on biochemical, neurophysiologic, and indirect measurements of autonomic activity indicate that visceral obesity and the metabolic syndrome are associated with enhanced sympathetic neural drive and vagal impairment.
SLEEPEmpirical Evidence for “Syndrome Z”: A Hierarchical 5-Factor Model of the Metabolic Syndrome Incorporating Sleep Disturbance Measures
75 Citations2009Nora L. Nock, Li Li +3 more
A second-order factor model is evaluated, whereby syndrome Z was described by 5 first-order factors--insulin resistance, obesity, hypertension, dyslipidemia, and sleep disturbance--with the sleep disturbance factor defined using the apnea-hypopnea index, arousal index, percentage of sleep time with oxygen saturation less than 90%, and percentage of slow wave sleep to demonstrate that sleep disturbance coaggregates with other metabolic features to represent a single unifying trait, syndrome Z.
Clinics in Geriatric MedicineSleep in the elderly
75 Citations2003Steven H. Feinsilver
This article addresses normal sleep and the changes expected with aging, and reviews the more common sleep diseases in the elderly population, such as insomnia, sleep-disordered breathing, periodic limb movements of sleep, and the rapid eye movement sleep-behavior disorder.
PneumologieValidierung von microMESAM® als Screeningsystem für schlafbezogene Atmungsstörungen
70 Citations2003Y. Wang, T. Teschler +4 more
MicroMESAM-generated flow-time curves correspond well with pneumotachograph generated curves, producing automated AHIs that are highly sensitive in detecting SDB.
Sleep MedicineSnoring and the metabolic syndrome in women
61 Citations2003Constanze Leineweber, Göran Kecklund +3 more
Findings show that snoring women are not only at increased risk for individual risk factors associated with cardiovascular disease and type 2 diabetes, but also for metabolic syndrome.
Infectious Diseases in Clinical PracticeEXECUTIVE SUMMARY OF THE THIRD REPORT OF THE NATIONAL CHOLESTEROL EDUCATION PROGRAM (NCEP) EXPERT PANEL ON DETECTION, EVALUATION AND TREATMENT OF HIGH BLOOD CHOLESTEROL IN ADULTS
42 Citations2001&NA;
Journal of Psychiatric PracticeDiagnosis and Assessment of Sleep and Circadian Rhythm Disorders
41 Citations2005Daniel J. Buysse
An overview of the current state of knowledge concerning the function of sleep and sleep-wake rhythms, the neurobiology of circadian rhythms, how wakefulness and sleep are studied, and the clinical assessment and diagnosis ofSleep and circadian rhythm disorders is presented.
SLEEPShort Sleep and Obesity: Are Poor Sleep, Chronic Stress, and Unhealthy Behaviors the Link?
36 Citations2008Alexandros N. Vgontzas, Edward O. Bixler
It is concluded that short sleep duration is reported by obese individuals who complain of their sleep and are chronically stressed, and there was no association between objective sleep duration and BMI, suggesting that it is an individual's perception of sleep duration rather than actual sleep loss that correlates with obesity.