Letter to the editor
PainPublished 1 February 1988
Daniel Le Bars, Jean Claude Willer
Citations16
SJR quartileQ1
SJR score2.02
SNIP1.87
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Abstract
INSERM, Unité de Recherche de Neurophysiologie Pharmacologique (U-16I), 2, rue d'Alésia, 75014 ParisFrance Lab. Clinical Neurophysiology, University Paris VI (Pierre et Marie Curie), 75230 ParisFrance
Keywords
Medicine
PainDiffuse noxious inhibitory controls (DNIC). I. Effects on dorsal horn convergent neurones in the rat
1,352 Citations1979Daniel Le Bars, Anthony H. Dickenson +1 more
Since non‐noxious stimuli were ineffective in this respect, the term “diffuse noxious inhibitory controls” (DNIC) is proposed, and long lasting post‐effects directly related to the duration of conditioning painful stimulus were observed.
PainDiffuse noxious inhibitory controls (DNIC). II. Lack of effect on non-convergent neurones, supraspinal involvement and theoretical implications
770 Citations1979Daniel Le Bars, Anthony H. Dickenson +1 more
It is concluded that convergent neurones are specifically inhibited by DNIC, and the “contrast” between the messages from these two pools may well produce a significant pain signalling output from the convergent dorsal horn cells.
BrainPSYCHOPHYSICAL AND ELECTROPHYSIOLOGICAL APPROACHES TO THE PAIN-RELIEVING EFFECTS OF HETEROTOPIC NOCICEPTIVE STIMULI
385 Citations1984Willer Jc, Agnès Roby-Brami +1 more
The nociceptive flexion reflex (RIII reflex) and the concurrent subjective pain score elicited by right sural nerve stimulation at random intensities were studied in 10 healthy volunteers and a close relationship was found between the recruitment curves of the reflex and the pain score as a function of stimulus intensity.
BrainAN ELECTROPHYSIOLOGICAL INVESTIGATION INTO THE PAIN-RELIEVING EFFECTS OF HETEROTOPIC NOCICEPTIVE STIMULI
170 Citations1987Agnès Roby-Brami, B. Bussel +2 more
The results show that the effects of heterotopic nociceptive stimulation observed in normal man are possibly mediated by a complex loop involving supraspinal structures and underlines the similarity between this phenomenon and the Diffuse Noxious Inhibitory Controls described in the rat.
Brain ResearchDiffuse noxious inhibitory controls (DNIC). Effects on trigeminal nucleus caudalis neurones in the rat
153 Citations1980Anthony H. Dickenson, Daniel Le Bars +1 more
The results demonstrate that both the neuronal responses and DNIC at the trigeminal nucleus caudalis level in the rat are similar to those reported for the dorsal horn.
Brain ResearchDepression of activities of dorsal horn convergent neurones by propriospinal mechanisms triggered by noxious inputs; comparison with diffuse noxious inhibitory controls (DNIC)
123 Citations1983Samuel W. Cadden, Luis Villanueva +2 more
The results in the spinal preparations provide evidence for the existence of some propriospinal modulatory processes, triggered by the onset of noxious stimulation and acting on convergent neurones, to be very potent and associated with long-lasting post-effects whether the conditioning noxious stimuli are applied to parts of the body proximal or distal to the excitatory receptive field.
Journal of NeurophysiologyInvolvement of the dorsolateral funiculus in the descending spinal projections responsible for diffuse noxious inhibitory controls in the rat
93 Citations1986Luis Villanueva, Djamel Chitour +1 more
It is concluded that the descending projections involved in the triggering of DNIC are mainly, if not entirely, confined to the DLF ipsilateral to the neuron under study, and the contralateral DLF did not appear to play a role in these processes.
Brain ResearchDiffuse noxious inhibitory controls of lumbar spinal neurons involve a supraspinal loop in the cat
88 Citations1987C.R. Morton, Birgit Maisch +1 more
In anesthetized cats, lumbar dorsal horn neurons were excited by brief noxious radiant heating of glabrous hindpaw skin but were inhibited by concomitant repetitive electrical stimulation of the ipsilateral deep radial nerve.
Journal of NeurophysiologyAscending pathways in the spinal cord involved in triggering of diffuse noxious inhibitory controls in the rat
78 Citations1986Luis Villanueva, Marc Peschanski +2 more
The loss of inhibitory effects was characterized by a complete disappearance of poststimulus effects, whereas inhibition observed during the application of the noxious thermal conditioning stimulus was only partially, albeit very significantly, blocked.
Brain ResearchThe encoding of thermal stimuli by diffuse noxious inhibitory controls (DNIC)
78 Citations1981Daniel Le Bars, Djamel Chitour +1 more
Investigation of the relationship between stimulus intensity and its efficacy in inducing diffuse noxious inhibitory controls in anaesthetized rats provided support for the notion of an involvement of inhibitory processes (DNIC) in the signalling of pain by convergent neurones.
Journal of Neurology Neurosurgery & PsychiatryPain in sciatica depresses lower limb nociceptive reflexes to sural nerve stimulation.
74 Citations1987J.C. Willer, Anna Barranquero +2 more
The inhibitory effects of acute pain produced by the Lasègue's manoeuvre on the lower limb nociceptive flexion reflexes induced by electrical sural nerve stimulation were explored in patients complaining of sciatica as a result of an identified unilateral disc protrusion.
Brain ResearchThe encoding of thermal stimuli applied to the tail of the rat by lowering the excitability of trigeminal convergent neurones
49 Citations1985Luis Villanueva, Daniel Le Bars
The responses to A- and C-fibre activation induced by supramaximal transcutaneous electrical stimulation of their receptive fields were conditioned by thermal stimuli applied to the tail, and the relationship between the conditioning temperatures and their ability to induce inhibitions of the evoked discharges of convergent neurones were investigated.
Brain ResearchMorphine antagonizes inhibitory controls of nociceptive reactions, triggered by visceral pain in the rat
19 Citations1986Eric Kraus, Daniel Le Bars
It is concluded that morphine antagonizes the heterotopic hypoalgesic effects of visceral pain, which does not support the hypothesis that morphine increases inhibitory controls of pain triggered by noxious inputs.
Brain ResearchThe response to viscero-peritoneal nociceptive stimuli is reduced in experimental arthritic rats
17 Citations1986Bernard Calvino, Daniel Le Bars
It is concluded that in this chronic pain model, the behavioral reaction to a viscero-peritoneal nociceptive stimulus is impaired and endogenous opioid systems could be involved in this phenomenon.