Spin label studies on synaptosomal membranes of rat brain cortex during aging
Biochemical and Biophysical Research CommunicationsPublished 1 December 1983
Katalin Nagy, P. Simon, Imre Zs.-Nagy
Citations49
SJR quartileQ2
SJR score0.75
SNIP0.56
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TL;DR
It is demonstrated that the hydrophobic region of synaptosomal membranes became more rigid during the life span studied, and the region located nearer the surface of membranes displays a significantly decreased fluidity only in the oldest group.
Abstract
Membrane lipids of brain synaptosomes of 2, 12 and 24 months old rats were labeled by stearic acid spin probes with a doxyl group in the C-5 and C-16 position, respectively. We demonstrated that the hydrophobic region of synaptosomal membranes became more rigid during the life span studied, and the region located nearer the surface of membranes displays a significantly decreased fluidity only in the oldest group. Membrane proteins labeled with a nitroxide derivative of maleimide suggest that conformational changes take place during aging.
Keywords
NeuroscienceBiochemistry, Genetics and Molecular Biology
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