Growth-inhibiting effect of crude pineal extracts on human melanoma cellsin vitro is different from that of known synthetic pineal substances
Journal of Neural TransmissionPublished 1 September 1987
Hella Bartsch, Christian Bartsch, H.P.J.M. Noteborn, Bertram Flehmig, I. Ebels, C. A. Salemink
Citations24
SJR quartileQ1
SJR score1.11
SNIP1.13
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TL;DR
Pineal substances as well as some of their analogues showed an inhibitory effect only at non-physiologically high concentrations, however, crude pineal extracts were more active than the synthetic pineal substances tested.
Abstract
The effect was studied of a number of synthetic indoleamines, pteridines, beta-carbolines, of AVT and of crude extracts from rat and ovine pineal glands on human melanoma cells in vitro. The identified pineal substances as well as some of their analogues showed an inhibitory effect only at non-physiologically high concentrations. However, crude pineal extracts were more active than the synthetic pineal substances tested. They contain a compound which may have a tumor-inhibiting potency comparable to that of methotrexate but a different mechanism of action.
Keywords
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