ALCOHOL HYPOGLYCEMIA. I. CARBOHYDRATE METABOLISM OF PATIENTS WITH CLINICAL ALCOHOL HYPOGLYCEMIA AND THE EXPERIMENTAL REPRODUCTION OF THE SYNDROME WITH PURE ETHANOL*
Journal of Clinical InvestigationPublished 1 July 1963Open access
Norbert Freinkel, David Singer, Ronald A. Arky, Sheldon J. Bleicher, John Anderson, Cynthia K. Silbert
Citations213
SJR quartileQ1
SJR score4.72
SNIP2.17
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
In 1941, Brown and Harvey described hypoglycemia after alcoholic debauch in six chronic alcoholics from the Baltimore area, and in 1942, Tucker and Porter noted four cases among chronicalcoholics from Richmond, Virginia.
Keywords
MedicinePharmacology, Toxicology and Pharmaceutics
Journal of Biological ChemistryA PHOTOMETRIC ADAPTATION OF THE SOMOGYI METHOD FOR THE DETERMINATION OF GLUCOSE
10,331 Citations1944Norton Nelson
American Journal of Clinical PathologyA Colorimetric Method for the Determination of Serum Glutamic Oxalacetic and Glutamic Pyruvic Transaminases
9,972 Citations1957Stanley Reitman, Sam Frankel
Journal of Clinical InvestigationA RELATION BETWEEN NON-ESTERIFIED FATTY ACIDS IN PLASMA AND THE METABOLISM OF GLUCOSE
3,472 Citations1956Vincent P. Dole
Journal of Clinical InvestigationIMMUNOASSAY OF ENDOGENOUS PLASMA INSULIN IN MAN
3,035 Citations1960Rosalyn S. Yalow, Solomon A. Berson
Journal of Lipid ResearchTitration of free fatty acids of plasma: a study of current methods and a new modification
1,025 Citations1960David L. Trout, E. Harvey Estes +1 more
Journal of Clinical InvestigationINSULIN-I131 METABOLISM IN HUMAN SUBJECTS: DEMONSTRATION OF INSULIN BINDING GLOBULIN IN THE CIRCULATION OF INSULIN TREATED SUBJECTS 1
843 Citations1956Solomon A. Berson, Rosalyn S. Yalow +3 more
Obesity ResearchIMMUNOASSAY OF ENDOGENOUS PLASMA INSULIN IN MAN
460 Citations1996Rosalyn S. Yalow, Solomon A. Berson
The insulin concentration in plasma has been estimated from the degree of hypoglycemia produced in hypophysectomized, adrenalectomization, alloxan-diabetic rats, and from the increased oxidation of glucose-1-C14 by the rat epididymal fat pad.
The Journal of Clinical Endocrinology & MetabolismCLINICAL APPLICATION OF A NEW TEST OF PITUITARY RESERVE*
460 Citations1959Grant W. Liddle, Herschel L. Estep +3 more
American Journal of Clinical PathologyA Stable Starch Substrate for the Determination of Amylase in Serum and Other Body Fluids
400 Citations1959Wendell T. Caraway
Journal of Clinical InvestigationETHANOL METABOLISM AND PRODUCTION OF FREE ACETATE IN THE HUMAN LIVER
351 Citations1962Frank Lundquist, Niels Tygstrup +3 more
Journal of Clinical InvestigationFAMILIAL HYPOGLYCEMIA PRECIPITATED BY AMINO ACIDS
246 Citations1956W. A. Cochrane, W. W. Payne +2 more
It is suggested that in this particular type of hypoglycemia high protein diets should be avoided and small amounts of carbohydrate may be given after the ingestion of a meal containing protein to offset the effect of protein in lowering the concentration of sugar in the blood.
Journal of EndocrinologyFURTHER IMMUNOLOGICAL STUDIES ON THE FORM OF CIRCULATING INSULIN
146 Citations1962N. A. Samaan, W. J. Dempster +3 more
The Journal of Clinical Endocrinology & MetabolismTHE VALUE OF THE GLUCOSE TOLERANCE TEST, THE INSULIN TOLERANCE TEST, AND THE GLUCOSEINSULIN TOLERANCE TEST IN THE DIAGNOSIS OF ENDOCRINOLOGIC DISORDERS OF GLUCOSE METABOLISM1
136 Citations1941Russell Fraser, Fuller Albright +1 more
As an aid in the diagnosis of various diseases, it has for a long time been useful to study the glucose content of the blood and the determination of this under fasting conditions may at once give the clue to the diagnosis.
The Journal of Clinical Endocrinology & MetabolismTHE DIAGNOSTIC VALUE OF SODIUM TOLBUTAMIDE IN HYPOGLYCEMIC STATES*†
120 Citations1961Stefan S. Fajans, Jack Schneider +2 more
Intravenous sodium tolbutamide tests were performed in patients with proven insulomas, functional hyperinsulinism, mild diabetes mellitus and associated postprandial hypoglycemia, severe adrenal insufficiency, and liver disease and provided supportive evidence that the primary mechanism of action of the sulfonylureas is release of pancreatic insulin.
DiabetesSpecific Enzymatic Determination of Glucose in Blood and Urine Using Glucose Oxidase
120 Citations1956E. R. Froesch, Albert E. Renold +1 more
Fermentation, formation of osazones, and chromatography have proved their usefulness, but being rather cumbersome and difficult to quantitate, have not found access to routine laboratories.
The Journal of Clinical Endocrinology & MetabolismSecondary Rise in Plasma Free Fatty Acids Following Glucose Load
111 Citations1962Robert E. Bolinger, Stanley R. Shane +1 more
Catecholamine response was studied during the glucose tolerance test by measuring the output of 3-methoxy-4-hydroxy mandelic acid at hourly intervals and a significant increase in the VMA excretion over the fasting level occurred in all but one of the cases.
Medical Clinics of North AmericaStudies on the Metabolic Response to Prolonged Fasting
106 Citations1960Francis C. Wood, L Domenge +3 more
The Journal of Clinical Endocrinology & MetabolismPLASMA EPINEPHRINE AND NOREPINEPHRINE LEVELS DURING INSULIN-INDUCED HYPOGLYCEMIA IN MAN*†
94 Citations1961Alan Goldfien, Robert F. Moore +4 more
Plasma epinephrine and norepinephrine concentrations were measured by the ethylenediamine technic before and during hypoglycemia in 11 patients undergoing insulin-coma therapy and in patients treated for more than three weeks, the control values were significantly elevated.
The Journal of Clinical Endocrinology & MetabolismSTUDY OF THE NORYMBERSKI METHODS FOR DETERMINATION OF 17-KETOGENIC STEROIDS (17-HYDROXYCORTICOSTEROIDS) IN URINE
93 Citations1958Charles Sobel, Orville J. Golub +3 more
From a study of a limited number of urine samples, both the 17-ketosteroids and the17-ketogenic steroids appear to be relatively stable at room temperature without added preservative.
Journal of Pharmacology and Experimental TherapeuticsURINARY EPINEPHRINE AND LEVARTERENOL EXCRETION DURING ACUTE SUBLETHAL ALCOHOL INTOXICATION IN DOGS
92 Citations1957Gerda I. Klingman, McC. Goodall
Alcohol intoxication in dogs produces a significant decrease in epinephrine content of the adrenal gland but no change in the levarterenol content.
Journal of Clinical InvestigationTHE EXPERIMENTAL INDUCTION IN MAN OF SENSITIVITY TO LEUCINE HYPOGLYCEMIA*
87 Citations1963Stefan S. Fajans, Ralph F. Knopf +3 more
The Journal of PediatricsAmino acid and alpha-keto acid-induced hyperinsulinism in the leucine-sensitive type of infantile and childhood hypoglycemia
79 Citations1960Melvin M. Grumbach, Selna L. Kaplan
It was shown that leucine caused increased peripheral utilization of glucose, suggesting an insulin-like action and direct determinations of plasma insulin indicated a sharp rise in circulating insulin following the administration ofLeucine.
Experimental Biology and MedicineDepression of Serotonin and Norepinephrine Levels in Brain Stem of Rabbit by Ethanol.
77 Citations1960Deha Gursey, R. E. Olson
Evidence is presented which indicates that intravenous infusion of 2 g/kg of ethanol produced depression of both serotonin and norepinephrine levels in the brain stem of rabbit, an effect which is reminiscent of the action of reserpine.
JAMASPONTANEOUS HYPOGLYCEMIA IN "SMOKE" DRINKERS
72 Citations1941Thomas McP. Brown
Although little information is gathered concerning the exact nature and cause of this hypoglycemic reaction, the patients concerned have all been chronically addicted to alcohol and have been drinkers of denatured alcohol in a form known locally as "smoke."
The Journal of PediatricsHypoglycemia and convulsions in children following alcohol ingestion
70 Citations1961Leo H. Cummins
When a child becomes comatose or convulses after ingesting an alcohol-containing substance, hypoglycemia may be present and blood should be drawn for glucose determination, and 50 per cent glucose should be injected through the same needle.
Archives of Internal MedicineTolbutamide Tolerance Test in Carbohydrate Metabolism Evaluation
54 Citations1961Norman M. Kaplan
The incidence of a "diabetic" response to oral glucose in a random population sample was 15 times the estimated frequency of diabetes in the general population, during 5- to 30-year follow-up studies.
Journal of Clinical InvestigationTHE INSULIN-GLUCOSE TOLERANCE TEST. A MODIFIED PROCEDURE FOR THE DETECTION OF HYPOGLYCEMIA UNRESPONSIVENESS IN PITUITARY AND ADRENAL INSUFFICIENCY
33 Citations1950Frank L. Engel, James Scott
A modification of the insulinolerance test, the insulin-glucose tolerance test, which was designed to overcome some of the disadvantages of the former test is described, which makes individual curves-difficult to evaluate.
Journal of Clinical InvestigationThe Effect of Glucagon on the Blood Glucose Level and the Clinical State in the Presence of Marked Insulin Hypoglycemia 12
28 Citations1957Jerome L. Schulman, Stanley E. Greben
Most of the values reported for blood sugar are reported as milligrams change in blood sugar which tends to minimize the differences due to method.
NatureElevated Serum Insulin associated with Leucine-induced Hypoglycæmia
18 Citations1960Angelo M. DiGeorge, Victor H. Auerbach +1 more
The previous experiences with two leucine-sensitive children have been reported in detail elsewhere; the present communication deals with new and pertinent observations about the administration or ingestion of L-leucine or leueine-containing proteins.
Experimental Biology and MedicineEffect of Intravenous Injection of Ethyl Alcohol on Gastric Secretion in Man.
16 Citations1932Henry W. Newman, H. G. Mehrtens
It would seem possible that the seat of action of alcohol as a stimulus to gastric secretion lies neither in the general circulation, nor at the surface of the gastric mucosa, but somewhere between the two, and further investigation is in progress.
The American Journal of SurgeryThe physiologic basis for evaluation of “fasting hypoglycemias”
13 Citations1963Norbert Freinkel, Sheldon J. Bleicher
The purpose of the present communication is to focus upon the determinants of bIood-sugar maintenance in the fasting state, and to create a physiologic framework of reference upon which the etioIogic, diagnostic and therapeutic considerations of “fasting hypoglycemia” may be projected.
BMJHypoglycaemia in Chronic Alcoholism
7 Citations1955J. S. Taylor
The patient, a man aged 54, was known to be a chronic alcoholic, and when he was examined there was a strong smell of ketones in the small airless room, and he was deeply comatose, lying flat on his back, with open eyes and giving an occasional twist of his head.
Quarterly Journal of Experimental Physiology and Cognate Medical SciencesHYPOGLYCÆMIA IN RATS AS A RESULT OF SPINAL CORD LESIONS
4 Citations1961J. van Gool, Claudia Korn
Probably the hypoglycaemia in pithed rats depends on a defect in gluconeogenesis, which is influenced by the abdominal sympathetic system.
EndocrinologyTHE EFFECT OF DUODENAL SECRETIN UPON THE SECRETION OF INSULIN BY THE PANCREAS
4 Citations1928ROBERTO NOVÓA SANTOS
A comparative study of the action of insulin and secretin upon blood sugar shows that the effect of insulin is the more intense.