STATE OF THE SCIENCE
Nursing Clinics of North AmericaPublished 1 March 1996
Christine Grady, Grace Kelly
Citations8
SJR quartileQ1
SJR score0.74
SNIP0.84
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Abstract
A vaccine to prevent HIV infection or disease would be a great benefit to the global community. Efforts in the development of such a preventive vaccine have been hampered by a number of formidable scientific, logistic, ethical, and political challenges, yet scientists remain optimistic about the possibility. The state of the science as of early 1995 has been summarized in this article. A growing number and variety of vaccine concepts and products are being tested in animals and humans (including, for example, pseudovirions, naked DNA, and live attenuated mutants, with specific gene deletions, among others). Trials are exploring whether changing immunization schedules, increasing booster doses, or using a combination vaccine strategy can stimulate stronger, durable immune responses. Progress in basic and clinical research and advances in molecular biology, genetics, and technology continue to create promising opportunities for vaccines.
Keywords
Immunology and MicrobiologySocial SciencesMedicine
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