N-Heterocyclic Carbene-Catalyzed Amidation of Unactivated Esters with Amino Alcohols
Organic LettersPublished 17 May 2005
Mohammad Movassaghi, Michael A. Schmidt
Citations293
SJR quartileQ1
SJR score1.24
SNIP1.03
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TL;DR
A series of solution studies in addition to the first X-ray structure of a carbene-alcohol complex support acarbene-base nucleophile activation mechanism.
Abstract
[reaction: see text] A catalytic amidation of unactivated esters with amino alcohols is described. A series of solution studies in addition to the first X-ray structure of a carbene-alcohol complex support a carbene-base nucleophile activation mechanism.
Keywords
ChemistryBiochemistry, Genetics and Molecular Biology
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