Resting metabolic rate in homozygous sickle cell disease
American Journal of Clinical NutritionPublished 1 January 1993
Ash Singhal, Peter F. Davies, Amrik Sahota, Peter Thomas, GR Serjeant
Citations96
SJR quartileQ1
SJR score2.11
SNIP1.75
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TL;DR
The resting metabolic rate in 20 patients with homozygous sickle cell (SS) disease was 19% higher than in 20 age- and sex-matched control subjects with a normal hemoglobin genotype (AA).
Abstract
The resting metabolic rate in 20 patients with homozygous sickle cell (SS) disease was 19% higher than in 20 age- and sex-matched control subjects with a normal hemoglobin genotype (AA). The difference was not accounted for by differences in lean body mass. It is postulated that this increased energy expenditure reflects the energy expenditure of erythropoietic hyperplasia and leads to a marginal nutritional state that may contribute to the abnormal growth in SS disease.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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