TOXIC DEPRESSION OF THE MYELOID ELEMENTS FOLLOWING THERAPY WITH THE SULFONAMIDES; REPORT OF 8 CASES

The discovery of the therapeutic effectiveness of sulfanilamide and its related substances constitutes one of the greatest advances in medical therapeutics rivaling that of arsphenamine and...

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Article1 July 1941TOXIC DEPRESSION OF THE MYELOID ELEMENTS FOLLOWING THERAPY WITH THE SULFONAMIDES; REPORT OF 8 CASESSOLOMON S. RINKOFF, M.D., MAXWELL SPRING, M.D.SOLOMON S. RINKOFF, M.D.Search for more papers by this author, MAXWELL SPRING, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-15-1-89 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe discovery of the therapeutic effectiveness of sulfanilamide and its related substances constitutes one of the greatest advances in medical therapeutics rivaling that of arsphenamine and its compounds in the treatment of lues, and that of quinine in the treatment of malaria.The medical profession embraced these new drugs with great enthusiasm, and their use became widespread. Soon, however, reports of toxicity following the administration of these related substances appeared in the literature. Leukopenia, granulocytopenia and agranulocytosis were three of the more serious of the toxic manifestations.Young1in 1937, and Johnston2in 1938 were the first to report cases...References1. YOUNG CJ: Agranulocytosis and para-amino-benzene sulphonamide, Brit. Med. Jr., 1937, ii, 105. CrossrefGoogle Scholar2. JOHNSTON FD: Agranulocytosis following treatment with M & B 693, Lancet, 1938, ccxxxv, 1250. Google Scholar3. KRACKEGARVER AREC: Diseases of the blood and atlas of hematology, 1937, J. B. Lippincott Company, Philadelphia, p. 141. Google Scholar4. GROENGELDERMAN JCJ: Agranulocytose (maligne Neutropenie) door Due Geneesmiddelen, Nederl. tijdschr. v. geneesk., 1934, lxxviii, 3444. Google Scholar5. WEIN R: The toxicity of 2-(p-aminobenzene-sulphonamide-pyridine), Quart. Jr. Pharm. and Pharmacol., 1938, xi, 217-224. Google Scholar6. MOLLITORROBINSON HH: Acute, cumulative and chronic toxicity of sulfapyridine, Arch. Internat. de Pharmacodyn. et de Therap., 1938, lxii, 281-294. Google Scholar7. JOHANNSENST. GEORGE HWAV: Toxicity and therapeutic effect of sulphapyridine in animals, Am. Jr. Clin. Path., 1939, ix, 414-420. CrossrefGoogle Scholar8. WHITBY L: Chemotherapy of bacterial infections, Lancet, 1938, ccxxxv, 1095-1103. CrossrefGoogle Scholar9. MARSHALLBRATTONLITCHFIELD EKAGJT: Toxicity and absorption of 2-sulfanilamidopyridine and its soluble sodium salt, Science, 1938, lxxxviii, 597. CrossrefGoogle Scholar10. BROWNTHORNTONWILSON WHACJS: An evaluation of the clinical toxicity of sulfanilamide and sulfapyridine, Jr. Am. Med. Assoc., 1940, cxiv, 1605-1611. Google Scholar11. DOLGOPOLHOBART VBHM: Granulocytopenia in sulfapyridine therapy, Jr. Am. Med. Assoc., 1939, cxiii, 1012-1017. CrossrefGoogle Scholar12. BRIGGS GO: Granulopenia following the administration of M & B 693, Lancet, 1939, ii, 237. Google Scholar13. TZANCKARNOUSPAILLAS AJJP: Agranulocytose mortelle après administration de p-amino-benzène-sulfanilamidopyridine (693) à doses modérées, Bull. et mém. Soc. med. d. hôp. de Paris, 1939, lv, 576. Google Scholar14. ROSENTHALVOGEL NP: Granulocytopenia caused by sulfapyridine in children, Jr. Am. Med. Assoc., 1939, cxiii, 584-587. CrossrefGoogle Scholar15. GARVIN CF: Complications following administration of sulfanilamide, Jr. Am. Med. Assoc., 1939, cxiii, 288. CrossrefGoogle Scholar16. SHECKETPRICE HAAE: Fatal granulocytopenia following administration of sulfanilamide, Jr. Am. Med. Assoc., 1939, cxii, 823. CrossrefGoogle Scholar17. MORGANDETWEILER JRHK: The hematologic study of 76 pneumonias treated with sulfapyridine including a fatal case of agranulocytosis, Jr. Lab. and Clin. Med., 1939, xxv, 275-281. Google Scholar18. SUTHERLAND ME: Agranulocytosis following the administration of M & B 693, Lancet, 1939, i, 1208-1209. CrossrefGoogle Scholar19. LONG PH: Quoted by BROWN, A. E., and HERRELL, W. E.: Clinical experience with sulfamethylthiazole, Am. Jr. Med. Sci., 1940, cc, 618. Google Scholar20. REINHOLD JG: Observations on the pharmacology and toxicology of sulfathiazole in man, Am. Jr. Med. Sci., 1940, cxcix, 393. CrossrefGoogle Scholar21. Personal communication with DRS. CHARLES HOCHMAN and LOUIS LEFKOWITZ, Asst. Med. Examiners, Bronx County. Google Scholar22. FILLER WE: Puerperal sepsis due to Staphylococcus aureus treated successfully with sulfamethylthiazol, Am. Jr. Obst. and Gynec., 1941, xli, 145. CrossrefGoogle Scholar23. KENNEDYFINLAND PCM: Agranulocytosis from sulfathiazole, Jr. Am. Med. Assoc., 1941, cxvi, 295. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bronx, New York*Received for publication December 9, 1940.From The Bronx Hospital, New York. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySulfonamidesANTIBACTERIAL DRUGSGLUCOCORTICOIDS AND DISEASE – MODIFYING ANTIRHEUMATIC DRUGSSulfonamidesThe Role of Leukocyte-Generated Reactive Metabolites in the Pathogenesis of Ideosyncratic Drug ReactionsThe role of N-oxidation by leukocytes in drug-induced agranulocytosis and other drug hypersensitivity reactionsDrug Metabolism by Leukocytes and Its Role in Drug-Induced Lupus and Other Idiosyncratic Drug ReactionsDifferences in Metabolism of Sulfonamides Predisposing to Idiosyncratic ToxicityNEIL H. SHEAR, M.D., STEPHEN P. SPIELBERG, M.D., Ph.D., DENIS M. GRANT, Ph.D., BING K. TANG, Ph.D., WERNER KALOW, M.D.Toxicity of CarbutamideHemocytopenic Reactions to Modern DrugsAllergy to DrugsTREATMENT OF SUBACUTE INFECTIVE ENDOCARDITIS WITH HEPARIN AND CHEMOTHERAPY 1 July 1941Volume 15, Issue 1Page: 89-107KeywordsBloodDrugsMalariaQuinineSulfonamideToxicity ePublished: 1 December 2008 Issue Published: 1 July 1941 PDF downloadLoading ...