Antagonism by Aspirin and Fenamates of Bronchoconstriction and Nociception induced by Adenosine-5′-triphosphate

Both the bronchoconstrictor and the nociceptive responses were antagonized by salts of aspirin and of three aryl anthranilic acids (flufenamic3, mefenamic4 and meclofenamic5), which are collectively call ‘fenamates’.

Abstract

ADENOSINE triphosphate (ATP) and related adenosine phosphates cause bronchoconstriction in guinea-pig isolated lungs, and, in relatively high doses, increase air overflow volume in the Konzett-Rössler preparation of guinea-pig lungs in vivo1. ATP elicits pain in man when applied to an exposed blister base2, as do several other endogenous substances that induce bronchoconstriction in the guinea-pig. We have confirmed that ATP increases air overflow volume in the Konzett-Rössler preparation of the guinea-pig and we have found that, in keeping with its algogenic action in man, ATP induced a nociceptive response in mice. Both the bronchoconstrictor and the nociceptive responses were antagonized by salts of aspirin and of three aryl anthranilic acids (flufenamic3, mefenamic4 and meclofenamic5), which we shall collectively call 'fenamates'.