Importance of Multiagent Chemotherapy Regimens in Ovarian Carcinoma: Dose Intensity Analysis

The results support other published findings that use of cyclophosphamide and doxorubicin increases the efficacy of single-agent platinum, and Prospective clinical trials are required to test the effect of higher relative dose intensity for doxorbicin and cycloph phosphamide added to platinum in advanced ovarian cancer.

Abstract

Prospective clinical trials are required to test the effect of higher relative dose intensity for doxorubicin and cyclophosphamide added to platinum in advanced ovarian cancer. An important element in the design of prospective trials will be to test for the relative importance of dose intensity versus total dose. This testing is best achieved in a three-arm study design such as that reported in adjuvant treatment of stage II breast cancer conducted by the Cancer and Leukemia Group B.