Maternal erythropoietin in singleton pregnancies: A randomized trial on the effect of oral hematinic supplementation
American Journal of Obstetrics and GynecologyPublished 1 March 1994
Desmond P.J. Barton, Marie-Therese Joy, Terence R.J. Lappin, Morteza Afrasiabi, Jorge G. Morel, Joan O’Riordan
Citations39
SJR quartileQ1
SJR score2.77
SNIP2.75
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TL;DR
Maternal serum erythropoietin increased during pregnancy, but this response was reduced in the third trimester in the hematinic-supplemented group.
Abstract
Maternal serum erythropoietin increased during pregnancy, but this response was reduced in the third trimester in the hematinic-supplemented group.
Keywords
Medicine
BloodEffect of inflammatory cytokines on hypoxia-induced erythropoietin production
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225 Citations1981John A. Widness, John B. Susa +6 more
The mechanism for the increased plasma Ep associated with hyperinsulinemia in the fetus is unexplained but may be mediated by fetal hypoxia.
The LancetA CONCEPT OF NATURAL FIBRINOLYSIS
216 Citations1961G. R. Fearnley
This short but highly specialized article suggests that the belief that thrombus formation is an unidirectional accident and that all the blood remains fluid all the time unless such an accident occurs may be far from the truth.
British Journal of HaematologyIron Stores in Pregnancy
168 Citations1977V. Fenton, I. Cavill +1 more
The results suggest that maternal erythroid activity starts early in pregnancy and may exhaust the iron stores before the fetal demands for iron can be met.
Journal of Clinical InvestigationErythropoietin messenger RNA levels in developing mice and transfer of 125I-erythropoietin by the placenta.
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The results indicate that in mice the kidney is the main organ of EP production at all stages of postnatal development and that adult kidney may also play some role in providing EP for fetal erythropoiesis via placental transfer of maternal hormone.
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148 Citations1979David J. Taylor, T. Lind
Red cell mass, derived from plasma volume and haematocrit, was calculated serially in 45 healthy women during pregnancy and 4 to 6 months after delivery and an increase in red cell mass occurred thereafter.
BJOG An International Journal of Obstetrics & GynaecologyIron requirement in normal pregnancy as assessed by serum ferritin, serum transferrin saturation and erythrocyte protoporphyrin determinations
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Serum ferritin was the most sensitive and specific test of iron deficiency, and a practical procedure to detect iron deficiency and to control iron supplementation in pregnancy is suggested.
PubMedAmniotic fluid erythropoietin correlates with umbilical plasma erythropoietin in normal and abnormal pregnancy.
121 Citations1987Teramo Ka, John A. Widness +4 more
It is speculated that amniotic fluid erythropoietin may be an antepartum indicator of fetal hypoxemia and is correlated highly significantly in all three individual groups in absence of labor.
American Journal of Obstetrics and GynecologyFetal plasma erythropoietin concentration in severe growth retardation
117 Citations1993R. J. M. Snijders, A. Abbas +3 more
American Journal of Obstetrics and GynecologyFetal plasma erythropoietin in pregnancies complicated by maternal diabetes mellitus
103 Citations1993Douglas R. Salvesen, J. M. Brudenell +3 more
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94 Citations1993Ajit Singh, Kai‐Uwe Eckardt +6 more
Plasma viscosity may be a significant inhibitory modulator of anemia-induced EPO formation and may contribute to the inappropriate EPO production, which is a major reason for the anemia developing in these patients.
BloodBlunted erythropoietin production and decreased erythropoiesis in early pregnancy [see comments]
83 Citations1991Yves Béguin, G Lipscei +2 more
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67 Citations1984John A. Widness, Gisela K. Clemons +3 more
It is concluded that in uncomplicated pregnancies the duration and intensity of labor are sufficient to cause an increase in the fetal erythropoietin level at delivery.
American Journal of Obstetrics and GynecologyAmniotic fluid erythropoietin predicts fetal distress in Rh-immunized pregnancies
52 Citations1989Petri Voutilainen, John A. Widness +3 more
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BloodBlunted erythropoietin production and decreased erythropoiesis in early pregnancy [see comments]
51 Citations1991Yves Béguin, G Lipscei +2 more
It is concluded that erythropoiesis is decreased in the first part of pregnancy but increases afterwards; and blunted Epo production in early pregnancy could be responsible for that observation.
British Journal of HaematologyErythropoiesis in pregnancy
45 Citations1986M. R. Howells, Stephen Jones +3 more
The reticulocyte count, serum ferritin and serum erythropoietin concentrations were measured during the course of pregnancy in 41 women and were consistent with an increase in eryanthropoietic activity early in pregnancy which did not appear to depend upon increased plasma erythroietin levels.
American Journal of Obstetrics and GynecologyPlasma immunoreactive erythropoietin in normal women studied sequentially during and after pregnancy
44 Citations1984John A. Widness, Gisela K. Clemons +2 more
It is speculated that the increase in erythropoietin levels during pregnancy acts as a trophic stimulus for effecting an increase in maternal red blood cell mass presumably to meet the increased metabolic (oxygen) demands of pregnancy.
British Journal of HaematologySerum immunoreactive erythropoietin during pregnancy and in the early postpartum
41 Citations1990Yves Béguin, G Lipscei +3 more
It is concluded that EPO response to anaemia is impaired in early pregnancy, recovers in late pregnancy, and normalizes rapidly in the postpartum.
PubMedEndocrine control of maternal and fetal erythropoiesis.
41 Citations1968Joanne H. Jepson
The increased erythropoietic activity found in plasma during late gestation, despite the low amount of erythro¬ poietin excreted in the urine at this time, is an interesting observation which may be related to several factors including altered metabolism and excretion, increased tubular re absorption or increased binding of this hormone to a plasma protein carrier.
American Journal of Obstetrics and GynecologyFetal plasma erythropoietin concentration in red blood cell-isoimmunized pregnancies
34 Citations1992B. Thilaganathan, Douglas R. Salvesen +3 more
PubMedMaternal alcohol abuse is associated with elevated fetal erythropoietin levels.
30 Citations1990Erja Halmesmäki, Teramo Ka +3 more
Maternal alcohol ingestion during pregnancy is associated with elevated umbilical erythropoietin levels, but whether this is a direct effect of ethanol or is induced by chronic fetal hypoxemia remains unclear.
British Journal of HaematologyComparison of the mouse spleen cell assay and a radioimmunoassay for the measurement of serum erythropoietin
28 Citations1988Terence R.J. Lappin, G. E. Elder +3 more
It is concluded that the RIA is more reliable than the MSCA which, in its present form, cannot be recommended for the accurate measurement of serum erythropoietin.
PubMedRegulation of erythropoiesis in fetus and mother during normal pregnancy.
20 Citations1982J Zivný, J Kobilková +2 more
The assay results prove, indirectly, the hypothesis that increased production of erythrocytes in pregnancy is mediated by the erythropoietin humoral mechanism in both fetus and mother.
BJOG An International Journal of Obstetrics & GynaecologyERYTHROCYTE 2,3‐DIPHOSPHOGLYCERATE AND ASSOCIATED HAEMATOLOGICAL PARAMETERS DURING THE MENSTRUAL CYCLE AND PREGNANCY
17 Citations1977Rosemary Macdonald, H. N. Macdonald
It is concluded that ‘functional anaemia’, secondary to increased oxygen demand, is a more important stimulus than the decrease in haemoglobin concentration.